§ 522.1660b Oxytetracycline solution, 300 milligrams/milliliter.

Specifications.(a) Each milliliter (mL) of solution contains 300 milligrams (mg) oxytetracycline base.

Sponsor.(b) See No. 055529 in § 510.600(c) of this chapter.

Related tolerances.(c) See § 556.500 of this chapter.

Special considerations.(d) When labeled for use as in paragraph (e)(1)(i)(D) or (e)(1)(i)(E) of this section, labeling shall also bear the following: “Federal law restricts this drug to use by or on the order of a licensed veterinarian.”.

Conditions of useBeef cattle, nonlactating dairy cattle, and calves including preruminating (veal) calvesAmounts and indications for use.PasteurellaHistophilusFusobacterium necrophorum,Escherichia coli,Actinobacillus lignieresii,Leptospira pomona,StaphylococcusStreptococcus(e) —(1) —(i) (A) 3 to 5 mg per pound of bodyweight (mg/lb BW) per day (/day) intramuscularly, subcutaneously, or intravenously for treatment of pneumonia and shipping fever complex associated with spp. and spp., foot-rot and diphtheria caused by bacterial enteritis (scours) caused by wooden tongue caused by leptospirosis caused by wound infections and acute metritis caused by spp. and spp.

(B) 5 mg/lb BW/day intramuscularly, subcutaneously, or intravenously for treatment of severe foot-rot, and advanced cases of other indicated diseases.

Moraxella bovis.(C) 9 mg/lb BW intramuscularly or subcutaneously as single dosage where retreatment of calves and yearlings for bacterial pneumonia is impractical or for treatment of infectious bovine keratoconjunctivitis (pinkeye) caused by

Moraxella bovis.(D) 9 to 13.6 mg/lb BW intramuscularly or subcutaneously as single dosage where retreatment of calves and yearlings for bacterial pneumonia is impractical or for treatment of infectious bovine keratoconjunctivitis (pinkeye) caused by

MannheimiaPasteurellahaemolytica.(E) 13.6 mg/lb BW intramuscularly or subcutaneously as a single dosage for control of respiratory disease in cattle at high risk of developing BRD associated with ()

Limitations.(ii) Treatment should be continued 24 to 48 hours following remission of disease signs, however, not to exceed a total of four consecutive days. Do not inject more than 10 mL per site in adult cattle, reducing the volume according to age and body size to 1 to 2 mL in small calves. Exceeding the highest recommended level of drug/lb BW/day, administering more than the recommended number of treatments, and/or exceeding 10 mL intramuscularly or subcutaneously per injection site may result in antibiotic residues beyond the withdrawal time. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. Discontinue treatment at least 28 days prior to slaughter. Not for use in lactating dairy animals. For No. 055529: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

SwineAmounts and indications for use.E.coli.(2) —(i) (A) Sows: 3 mg/lb BW intramuscularly once, approximately 8 hours before farrowing or immediately after completion of farrowing, as an aid in control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by

E.coli,Pasteurella multocida,Leptospira pomona.(B) 3 to 5 mg/lb BW/day intramuscularly for treatment of bacterial enteritis (scours, colibacillosis) caused by pneumonia caused by and leptospirosis caused by

(C) 9 mg/lb BW as a single dosage where retreatment for pneumonia is impractical.

Limitations.(ii) Administer intramuscularly. Treatment should be continued 24 to 48 hours beyond remission of disease signs, however, not to exceed a total of 4 consecutive days. Exceeding the highest recommended level of drug/lb BW/day, administering more than the recommended number of treatments, and/or exceeding 5 mL intramuscularly per injection site may result in antibiotic residues beyond the withdrawal time. Discontinue treatment at least 28 days prior to slaughter. For No. 055529: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

[68 FR 54805, Sept. 19, 2003. Redesignated and amended at 69 FR 31879, June 8, 2004; 73 FR 14926, Mar. 20, 2008; 88 FR 16548, Mar. 20, 2023]