Modification of Significant New Uses of Certain Chemical Substances (23-1.M)

Issuing agencies

Abstract

EPA is amending significant new use rules (SNURs) issued under section 5(a)(2) of the Toxic Substances Control Act (TSCA) for certain chemical substances identified herein, which were the subject of premanufacture notices (PMNs) and significant new use notices (SNUNs). This action amends the SNURs by allowing certain new uses reported in the SNUNs or PMNs without additional notification requirements, modifying the significant new use notification requirements based on the actions and determinations for the SNUN or PMN submissions or based on the examination of new test data or other information, and making technical amendments to several SNURs. EPA is issuing these amendments based on review of new and existing data for the chemical substances.

Full Text

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<title>Federal Register, Volume 91 Issue 216 (Tuesday, November 10, 2026)</title>
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[Federal Register Volume 91, Number 216 (Tuesday, November 10, 2026)]
[Rules and Regulations]
[Pages 72433-72438]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-22888]


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ENVIRONMENTAL PROTECTION AGENCY

40 CFR Parts 721 and 725

[EPA-HQ-OPPT-2022-0863; FRL-12967-02-OCSPP]
RIN 2070-AB27


Modification of Significant New Uses of Certain Chemical 
Substances (23-1.M)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Final rule.

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SUMMARY: EPA is amending significant new use rules (SNURs) issued under 
section 5(a)(2) of the Toxic Substances Control Act (TSCA) for certain 
chemical substances identified herein, which were the subject of 
premanufacture notices (PMNs) and significant new use notices (SNUNs). 
This action amends the SNURs by allowing certain new uses reported in 
the SNUNs or PMNs without additional notification requirements, 
modifying the significant new use notification requirements based on 
the actions and determinations for the SNUN or PMN submissions or based 
on the examination of new test data or other information, and making 
technical

[[Page 72434]]

amendments to several SNURs. EPA is issuing these amendments based on 
review of new and existing data for the chemical substances.

DATES: This rule is effective on January 11, 2027. For purposes of 
judicial review, this rule shall be promulgated at 1 p.m. (EST) on 
November 24, 2026.

ADDRESSES: The docket for this action, identified under docket 
identification (ID) number EPA-HQ-OPPT-2022-0863, is available online 
at <a href="https://www.regulations.gov">https://www.regulations.gov</a> or in person at the Office of Pollution 
Prevention and Toxics Docket (OPPT Docket) in the Environmental 
Protection Agency Docket Center (EPA/DC). Please review the visitor 
instructions and additional information about the docket available at 
<a href="https://www.epa.gov/dockets">https://www.epa.gov/dockets</a>.

FOR FURTHER INFORMATION CONTACT: 
    For technical information: Brianna Godwin, New Chemicals Division 
(7405M), Office of Pollution Prevention and Toxics, Environmental 
Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-
0001; telephone number: (202) 565-0076; email address: 
<a href="/cdn-cgi/l/email-protection#593e363d2e3037773b2b3038373738193c2938773e362f"><span class="__cf_email__" data-cfemail="0f68606b786661216d7d666e61616e4f6a7f6e21686079">[email&#160;protected]</span></a>.
    For general information on SNURs: Iliriana Mushkolaj, New Chemicals 
Division (7405M), Office of Pollution Prevention and Toxics, 
Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, 
DC 20460-0001; telephone number: (202) 564-6877; email address: 
<a href="/cdn-cgi/l/email-protection#09447c7a616266656863274065607b60686768496c7968276e667f"><span class="__cf_email__" data-cfemail="8ac7fff9e2e1e5e6ebe0a4c3e6e3f8e3ebe4ebcaeffaeba4ede5fc">[email&#160;protected]</span></a>.
    For general information on TSCA: The TSCA Assistance Information 
Service Hotline, Goodwill of the Finger Lakes, 422 South Clinton Ave., 
Rochester, NY 14620; telephone number: (800) 471-7127 or (202) 554-
1404; email address: <a href="/cdn-cgi/l/email-protection#aafef9e9eb87e2c5dec6c3c4cfeacfdacb84cdc5dc"><span class="__cf_email__" data-cfemail="095d5a4a482441667d6560676c496c7968276e667f">[email&#160;protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. Executive Summary

A. What is the Agency's authority for taking this action?

    TSCA section 5(a)(2) (15 U.S.C. 2604(a)(2)) authorizes EPA to 
determine that a use of a chemical substance is a ``significant new 
use.'' EPA must make this determination by rule after considering all 
relevant factors, including the factors in TSCA section 5(a)(2). 
Procedures and criteria for modifying or revoking SNUR requirements 
appear at 40 CFR 721.185 or 725.984 (for microorganisms).

B. What action is the Agency taking?

    EPA is finalizing amendments to the SNURs for certain chemical 
substances in 40 CFR part 721, subpart E and part 725, Subpart M (for 
microorganisms). A SNUR for a chemical substance designates certain 
activities as significant new uses. Persons who intend to manufacture 
or process a chemical substance for a significant new use must notify 
EPA at least 90 days before commencing that activity. The required 
notification (i.e., a SNUN) initiates EPA's evaluation of the intended 
use. Manufacture and processing for the significant new use may not 
commence until EPA has conducted a review of the notice, made an 
appropriate determination on the notice, and taken such actions as are 
required in association with that determination.
    Previously, EPA proposed amendments to the SNURs for these chemical 
substances in the Federal Register of October 28, 2025, (90 FR 48717 
(FRL-12967-01-OCSPP)). The docket includes information considered by 
the Agency in developing the proposed and final rules, including public 
comments and EPA's responses to the comments received as discussed in 
Unit II.D.

C. Does this action apply to me?

1. General Applicability
    This action applies to you if you manufacture, process, or use the 
chemical substances identified in this document. The following list of 
North American Industrial Classification System (NAICS) codes is not 
intended to be exhaustive, but rather provides a guide to help readers 
determine whether this document applies to them. Potentially affected 
entities may include:
    <bullet> Manufacturers or processors of one or more subject 
chemical substances (NAICS codes 325 and 324110), e.g., chemical 
manufacturing and petroleum refineries.
2. Applicability to Importers and Exporters
    This action may also apply to certain entities through pre-existing 
import certification and export notification requirements under TSCA 
(<a href="https://www.epa.gov/tsca-import-export-requirements">https://www.epa.gov/tsca-import-export-requirements</a>).
    Chemical importers are subject to TSCA section 13 (15 U.S.C. 2612), 
the requirements in 19 CFR 12.118 through 12.127, 19 CFR 127.28, and 40 
CFR part 707, subpart B. Importers of chemical substances in bulk form, 
as part of a mixture, or as part of an article (if required by rule) 
must certify that the shipment of the chemical substance complies with 
all applicable rules and Orders under TSCA, including regulations 
issued under TSCA sections 5, 6, 7 and Title IV.
    Pursuant to 40 CFR 721.20 or 40 CFR 725.920 (for microorganisms), 
any persons who export or intend to export a chemical substance 
identified in this document are subject to the export notification 
provisions of TSCA section 12(b) (15 U.S.C. 2611(b)) and must comply 
with the export notification requirements in 40 CFR part 707, subpart 
D.

D. What are the incremental economic impacts of this action?

    EPA has evaluated the potential costs of establishing SNUN 
reporting requirements for potential manufacturers and processors of 
the chemical substances identified in this document. This analysis, 
which is available in the docket, is briefly summarized here.
1. Estimated Costs for SNUN Submissions
    A SNUR requires that any person who intends to engage in such 
activity in the future must first notify EPA by submitting a SNUN. If a 
SNUN is submitted, costs are an estimated $45,000 per SNUN submission 
for large business submitters and $14,500 for small business 
submitters. These estimates include the cost to prepare and submit the 
SNUN (including registration for EPA's Central Data Exchange (CDX)), 
and the payment of a user fee. Businesses that submit a SNUN would be 
subject to either a $37,000 user fee required by 40 CFR 
700.45(c)(2)(ii) and (d), or, if they are a small business as defined 
at 13 CFR 121.201, a reduced user fee of $6,480 (40 CFR 
700.45(c)(1)(ii) and (d)). These estimates reflect the costs and fees 
as they are known at the time of this rulemaking.
2. Estimated Costs for Export Notifications
    EPA has also evaluated the potential costs associated with the pre-
existing export notification requirements under TSCA section 12(b) and 
the implementing regulations at 40 CFR part 707, subpart D. For persons 
exporting a substance that is the subject of a SNUR, a one-time notice 
to EPA must be provided for the first export or intended export to a 
particular country. The total costs of export notification will vary by 
chemical, depending on the number of required notifications (i.e., the 
number of countries to which the chemical is exported). While EPA is 
unable to make any estimate of the likely number of export 
notifications for the chemical substances covered by these SNURs, as 
stated in the accompanying economic analysis, the estimated cost of the 
export

[[Page 72435]]

notification requirement on a per unit basis is approximately $106.

II. Background

A. General Information About SNURs

    Unit II. of the proposed rule provides general information about 
SNURs, and additional information about EPA's new chemical program is 
available at <a href="https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca">https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca</a>.

B. Applicability of the Significant New Use Designation

    To establish a significant new use, EPA must determine that the use 
is not ongoing. As discussed in Unit II.E. of the proposed rule, for 
one of the SNURs addressed in this rule, EPA proposed to designate as a 
``significant new use'' several additional uses that were not 
previously specifically designated as significant new uses under the 
existing SNURs, but which would be designated as significant new uses 
requiring notification if the proposed rule were finalized. EPA 
concluded that these proposed significant new uses were not ongoing. 
EPA also stated that if EPA subsequently determined that such a use was 
ongoing as of the date of publication of the proposed rule and did not 
cease prior to issuance of the final rule, EPA would not designate that 
use as a significant new use in the final rule. EPA has no information 
to suggest that any of the significant new uses identified in this rule 
meet this criterion.
    As discussed in the Federal Register of April 24, 1990 (55 FR 17376 
(FRL-3658-5)), EPA believes that the intent of TSCA section 5(a)(1)(B) 
is best served by designating a use as a significant new use as of the 
date of publication of the proposed rule rather than as of the 
effective date of the final rule. The objective of EPA's approach is to 
ensure that a person cannot impede finalization of a SNUR by initiating 
a significant new use after publication of the proposed rule but before 
the effective date of the final rule. Uses arising after the 
publication of the proposed rule are distinguished from uses that are 
identified in the final rule as having been ongoing on the date of 
publication of the proposed rule. The former would be new uses, the 
latter ongoing uses, except that uses that are identified as ongoing as 
of the publication of the proposed rule would not be considered ongoing 
uses if they have ceased by the date of issuance of a final rule.
    In the unlikely event that before a final rule becomes effective a 
person begins commercial manufacturing (including importing) or 
processing of the chemical substances for a use that is designated as a 
significant new use in that final rule, such a person would have to 
cease any such activity upon the effective date of the final rule. To 
resume their activities, these persons would have to first comply with 
all applicable SNUR notification requirements and wait until all TSCA 
prerequisites for the commencement of manufacture or processing have 
been satisfied.
    Issuance of a SNUR for a chemical substance does not signify that 
the chemical substance is listed on the TSCA Chemical Substance 
Inventory (TSCA Inventory). Guidance on how to determine if a chemical 
substance is on the TSCA Inventory is available on the internet at 
<a href="https://www.epa.gov/tsca-inventory">https://www.epa.gov/tsca-inventory</a>.

C. Important Information About SNUN Submissions

1. SNUN Submissions
    SNUNs must be submitted on EPA Form No. 7710-25, generated using e-
PMN software, and submitted to the Agency in accordance with the 
procedures set forth in 40 CFR 720.40 and 721.25. E-PMN software is 
available electronically at <a href="https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca">https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca</a>.
2. Development and Submission of Information
    EPA recognizes that TSCA section 5 does not require development of 
any particular new information (e.g., generating test data) before 
submission of a SNUN. There is an exception: If a person is required to 
submit information for a chemical substance pursuant to a rule, Order 
or consent agreement under TSCA section 4, then TSCA section 5(b)(1)(A) 
requires such information to be submitted to EPA at the time of 
submission of the SNUN.
    In the absence of a rule, TSCA Order, or consent agreement under 
TSCA section 4 covering the chemical substance, persons are required 
only to submit information in their possession or control and to 
describe any other information known to or reasonably ascertainable by 
them (see 40 CFR 720.50 or 40 CFR 725.160 (for microorganisms)). 
However, upon review of PMNs, SNUNs, and MCANS, the Agency has the 
authority to require appropriate testing. To assist with EPA's analysis 
of the SNUN, submitters are encouraged, but not required, to provide 
the potentially useful information as identified for the chemical 
substance in Unit III.C. of the proposed rule.
    EPA strongly encourages persons, before performing any testing, to 
consult with the Agency pertaining to protocol selection. Furthermore, 
pursuant to TSCA section 4(h), which pertains to reduction of testing 
in vertebrate animals, EPA encourages consultation with the Agency on 
the use of alternative test methods and strategies (also called New 
Approach Methodologies, or NAMs), if available, to generate the 
recommended test data. EPA encourages dialog with Agency 
representatives to help determine how best the submitter can meet both 
the data needs and the objective of TSCA section 4(h). For more 
information on alternative test methods and strategies to reduce 
vertebrate animal testing, visit <a href="https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce">https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce</a>.
    The potentially useful information described in Unit III. of the 
proposed rule may not be the only means of providing information to 
evaluate the chemical substance associated with the significant new 
uses. However, submitting a SNUN without any test data may increase the 
likelihood that EPA will take action under TSCA sections 5(e) or 5(f). 
EPA recommends that potential SNUN submitters contact EPA early enough 
so that they will be able to conduct the appropriate tests.
    SNUN submitters should be aware that EPA will be better able to 
evaluate SNUNs which provide detailed information about human exposure 
and environmental release that may result from the significant new use 
of the chemical substances.

D. Public Comments on Proposed Rule and EPA Responses

    EPA received public comments on the proposed amendments to the 
SNURs and prepared a Response to Comment document that provides the 
Agency responses. The comments and the Response to Comment document are 
available in the docket. EPA is finalizing the SNUR amendments as 
proposed except as described below (listed by PMN or MCAN number and 
proposed 40 CFR citation):
    <bullet> As described in the Response to Comment document, EPA is 
making one change to the SNUR for P-14-260 (40 CFR 721.10966) from the 
proposed rule in response to a comment. EPA modified the language to 
make clear that the 500 ft\3\ is a requirement and to remove the 
language about the large data storage rooms. The previous language was 
ambiguous and was not clear about limiting the use to 500 ft\3\.

[[Page 72436]]

    <bullet> For P-03-622 (40 CFR 721.10471), EPA is making non-
substantive corrections to the format of the proposed notification 
requirements as specified in the protection in the workplace and hazard 
communication sections.
    <bullet> For J-9-1 (40 CFR 725.1080), EPA is making a correction to 
the proposed recordkeeping and modification requirements for this 
microorganism as specified and the SNUR now references both 40 CFR 
725.950 and 725.984 in the recordkeeping and modification sections.

III. Chemical Substances Subject to These Significant New Use Rule 
Amendments and Changes

A. What is the designated cutoff date for ongoing uses?

    EPA designates the date of publication of the proposed rule as the 
cutoff date for determining whether the significant new uses are 
ongoing, i.e., October 28, 2025 (90 FR 48717 (FRL-12967-01-OCSPP)). Any 
unmodified significant new uses identified in existing SNURs would 
retain the cutoff date in the rulemaking establishing those significant 
new uses. This designation is explained in more detail in Unit II.B.

B. What information was provided for each chemical substance?

    In Unit III.C. of the proposed rule, EPA provided the following 
information for each chemical substance subject to these amended SNURs:
    <bullet> PMN number (the CFR citation assigned in the regulatory 
text section of this document).
    <bullet> Chemical name (generic name, if the specific name is 
claimed as CBI).
    <bullet> Chemical Abstracts Service Registry Number (CASRN) or 
Accession Number (if assigned, for confidential chemical identities).
    <bullet> Federal Register citation(s) for the previously issued 
final rules(s).
    <bullet> Basis for the proposed amendment.
    <bullet> Potentially useful information.
    The regulatory text section of this document specifies the chemical 
substances and activities designated as significant new uses. Certain 
new uses, including production volume limits and other uses designated, 
may be claimed as CBI, as discussed in more detail in Unit II.C. of the 
proposed rule.

IV. Statutory and Executive Order Reviews

    Additional information about these statutes and Executive Orders 
can be found at  <a href="https://www.epa.gov/laws-regulations-and-executive-orders">https://www.epa.gov/laws-regulations-and-executive-orders</a>.

A. Executive Order 12866: Regulatory Planning and Review

    This action establishes SNURs for chemical substances that were the 
subject of PMNs and an MCAN. The Office of Management and Budget (OMB) 
has exempted these types of actions from review under Executive Order 
12866 (58 FR 51735, October 4, 1993).

B. Executive Order 14192: Unleashing Prosperity Through Deregulation

    Executive Order 14192 (90 FR 9065, February 6, 2025) does not apply 
because a significant new use rule for a chemical under TSCA section 5 
is exempt from review under Executive Order 12866.

C. Paperwork Reduction Act (PRA)

    According to the PRA (44 U.S.C. 3501 et seq.), an agency may not 
conduct or sponsor, and a person is not required to respond to a 
collection of information that requires OMB approval under PRA, unless 
it has been approved by OMB and displays a currently valid OMB control 
number. The OMB control numbers for EPA's regulations in title 40 of 
the CFR, after appearing in the Federal Register, are listed in 40 CFR 
part 9, and included on the related collection instrument or form, if 
applicable.
    The information collection requirements related to SNURs have 
already been approved by OMB pursuant to PRA under OMB control number 
2070-0038 (EPA ICR No. 1188). This action does not impose any burden 
requiring additional OMB approval. If an entity were to submit a SNUN 
to the Agency, the annual burden is estimated to average between 30 and 
170 hours per submission. This burden estimate includes the time needed 
to review instructions, search existing data sources, gather and 
maintain the data needed, and complete, review, and submit the required 
SNUN.

D. Regulatory Flexibility Act (RFA)

    I certify that this action will not have a significant economic 
impact on a substantial number of small entities under the RFA (5 
U.S.C. 601 et seq.). The requirement to submit a SNUN applies to any 
person (including small or large entities) who intends to engage in any 
activity described in the final rule as a ``significant new use.'' 
Because these uses are ``new,'' based on all information currently 
available to EPA, EPA has concluded that no small or large entities 
presently engage in such activities.
    A SNUR requires that any person who intends to engage in such 
activity in the future must first notify EPA by submitting a SNUN. 
Although some small entities may decide to pursue a significant new use 
in the future, EPA cannot presently determine how many, if any, there 
may be. However, EPA's experience to date is that, in response to the 
promulgation of SNURs covering over 1,000 chemicals, the Agency 
receives only a small number of notices per year. For example, the 
number of SNUNs received was 7 in Federal fiscal year (FY) 2020, 9 in 
FY2021, 9 in FY2022, 23 in FY2023, 7 in FY2024, and 10 in FY 2025 and 
only a fraction of these submissions were from small businesses.
    In addition, the Agency currently offers relief to qualifying small 
businesses by reducing the SNUN submission fee from $37,000 to $6,480. 
This lower fee reduces the total reporting and recordkeeping cost of 
submitting a SNUN to about $14,500 per SNUN submission for qualifying 
small firms. Therefore, the potential economic impacts of complying 
with these proposed SNURs are not expected to be significant or 
adversely impact a substantial number of small entities. In a SNUR that 
published in the Federal Register of June 2, 1997 (62 FR 29684 (FRL-
5597-1)), the Agency presented its general determination that SNURs are 
not expected to have a significant economic impact on a substantial 
number of small entities, which was provided to the Chief Counsel for 
Advocacy of the Small Business Administration.

E. Unfunded Mandates Reform Act (UMRA)

    This action does not contain an unfunded mandate of $100 million or 
more (in 1995 dollars) in any one year as described in UMRA, 2 U.S.C. 
1531-1538, and does not significantly or uniquely affect small 
governments. Based on EPA's experience with proposing and finalizing 
SNURs, State, local, and Tribal governments have not been impacted by 
SNURs, and EPA does not have any reasons to believe that any State, 
local, or Tribal government will be impacted by these SNURs. In 
addition, the estimated costs of this action to the private sector do 
not exceed $183 million or more in any one year (the 1995 dollars are 
adjusted to 2023 dollars for inflation using the GDP implicit price 
deflator). The estimated costs for this action are discussed in Unit 
I.D.

F. Executive Order 13132: Federalism

    This action will not have federalism implications as specified in 
Executive Order 13132 (64 FR 43255, August 10,

[[Page 72437]]

1999), because it is not expected to have a substantial direct effect 
on States, on the relationship between the national government and the 
States, or on the distribution of power and responsibilities among the 
various levels of government. Accordingly, the requirements of 
Executive Order 13132 do not apply to this action.

G. Executive Order 13175: Consultation and Coordination With Indian 
Tribal Governments

    This action will not have Tribal implications as specified in 
Executive Order 13175 (65 FR 67249, November 9, 2000), because it is 
not expected to have substantial direct effects on Indian Tribes, 
significantly or uniquely affect the communities of Indian Tribal 
governments and does not involve or impose any requirements that affect 
Indian Tribes. Accordingly, the requirements of Executive Order 13175 
do not apply to this action.

H. Executive Order 13045: Protection of Children From Environmental 
Health Risks and Safety Risks

    This action is not subject to Executive Order 13045 (62 FR 19885, 
April 23, 1997), because it does not concern an environmental health or 
safety risk. Since this action does not concern a human health risk, 
EPA's 2026 Policy on Children's Health also does not apply. Although 
the establishment of these SNURs do not address an existing children's 
environmental health concern because the chemical uses involved are not 
ongoing uses, SNURs require that persons notify EPA at least 90 days 
before commencing manufacture (defined by statute to include import) or 
processing of the identified chemical substances for an activity that 
is designated as a significant new use by the SNUR. This notification 
allows EPA to assess the intended uses to identify potential risks and 
take appropriate actions before the activities commence.

I. Executive Order 13211: Actions Concerning Regulations That 
Significantly Affect Energy Supply, Distribution, or Use

    This action is not a ``significant energy action'' as defined in 
Executive Order 13211 (66 FR 28355, May 22, 2001), because it is not 
likely to have a significant adverse effect on the supply, 
distribution, or use of energy.

J. National Technology Transfer and Advancement Act (NTTAA)

    This action does not involve any technical standards subject to 
NTTAA section 12(d) (15 U.S.C. 272 note).

K. Congressional Review Act (CRA)

    This action is subject to the CRA (5 U.S.C. 801 et seq.), and EPA 
will submit a rule report to each House of the Congress and to the 
Comptroller General of the United States. This action is not a ``major 
rule'' as defined by 5 U.S.C. 804(2).

List of Subjects in 40 CFR Part 721 and 725

    Environmental protection, Chemicals, Hazardous substances, 
Reporting and recordkeeping requirements.

    Dated: November 4, 2026.
Mary Elissa Reaves,
Director, Office of Pollution Prevention and Toxics.

    For the reasons stated in the preamble, 40 CFR chapter I is amended 
as follows:

PART 721--SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES

0
1. The authority citation for part 721 continues to read as follows:

    Authority: 15 U.S.C. 2604, 2607, and 2625(c).


0
2. Amend Sec.  721.1725 by revising paragraph (b)(1)(i) to read as 
follows:


Sec.  721.1725  Benzoic acid, 3,3'-methylenebis [6 amino-, di-2-
propenyl ester.

* * * * *
    (b) * * *
    (1) * * *
    (i) The provisions of Sec.  721.11 apply to paragraph (a)(1) of 
this section and to chemical substances which are subject to a 
significant new use rule in Subpart E of this part.
* * * * *

0
3. Amend Sec.  721.2076 by revising paragraph (a)(1) to read as 
follows:


Sec.  721.2076  D-Glucuronic acid, polymer with 6-deoxy-L-mannose and 
D-glucose, acetate, calcium magnesium potassium sodium salt.

    (a) * * *
    (1) The chemical substance identified as D-glucuronic acid, polymer 
with 6-deoxy-L-mannose and D-glucose, acetate, calcium magnesium 
potassium sodium salt (PMN P-00-7; SNUNs S-05-1, S-06-4, S-07-03, and 
S-07-5; CAS No. 595585-15-2) is subject to reporting under this section 
for the significant new use described in paragraph (a)(2) of this 
section.
* * * * *

0
4. Amend Sec.  721.10070 by revising paragraphs (a)(1) and (a)(2)(i) to 
read as follows:


Sec.  721.10070  1,3-Butanediol, 3-methyl-.

    (a) * * *
    (1) The chemical substance identified as 1,3-butanediol, 3-methyl- 
(PMN P-05-309; SNUN S-13-4; CAS No. 2568-33-4) is subject to reporting 
under this section for the significant new uses described in paragraph 
(a)(2) of this section.
    (2) * * *
    (i) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80 (f). It is a significant new use to use 
the substance other than as inkjet ink or as a fixing agent of ink for 
inkjet printers.
* * * * *

0
5. Revise and republish Sec.  721.10471 to read as follows:


Sec.  721.10471  2-Propenoic acid, 1,1'-(3-methyl-1,5-pentanediyl) 
ester.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as 2-propenoic acid, 
1,1'-(3-methyl-1,5-pentanediyl) ester (PMN P-03-622; SNUNs S-17-5, S-
20-7, S-21-4, and S-23-7; CAS No. 64194-22-5) is subject to reporting 
under this section for the significant new uses described in paragraph 
(a)(2) of this section. The requirements of this section do not apply 
to quantities of the chemical substance after they have been completely 
reacted (cured).
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity (inhalation only), skin irritation, eye irritation, 
respiratory sensitization, skin sensitization, specific target organ 
toxicity, and aspiration hazard. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as

[[Page 72438]]

specified in Sec.  721.80(o). It is a significant new use to 
manufacture the substance in any manner that results in inhalation 
exposure to the substance. It is a significant new use to use the 
substance other than as a component of UV curable coatings and printing 
inks, additive manufacturing, adhesives, composites, 3D printing, and 
coating systems.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4) where N=11.
    (b) Specific requirements. The provisions of Subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers 
(including importers) and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.

0
6. Amend Sec.  721.10966 by revising paragraph (a)(2)(iii) to read as 
follows:


Sec.  721.10966  1-Propene, 2-bromo-3,3,3-trifluoro-.

    (a) * * *
    (2) * * *
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(c) and (f). It is a significant new use to 
use the substance other than as a fire extinguishing agent as a total 
flooding agent in unoccupied spaces, specifically engine nacelles and 
auxiliary power units (APUs) in aircraft; as a streaming fire 
extinguishing agent for use only in handheld extinguishers in aircraft; 
streaming in all non-residential uses, except for commercial home 
office and personal watercraft; or niche flooding application for 
unoccupied spaces up to 500 ft\3\.
* * * * *

0
7. Amend Sec.  721.11180 by revising paragraph (a)(2)(iii) to read as 
follows:


Sec.  721.11180  Arenesulfonic acid, alkyl derivatives, metal salts 
(generic).

    (a) * * *
    (2) * * *
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process or use the substance in any 
manner that results in the generation of a vapor, mist, spray, or 
aerosol.
* * * * *

PART 725--REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR 
MICROORGANISMS

0
8. The authority citation for part 725 continues to read as follows:

    Authority: 15 U.S.C. 2604, 2607, 2613, and 2625.


0
9. Amend Sec.  725.1080 by revising paragraphs (b)(1) and (2) to read 
as follows:


Sec.  725.1080  Trichoderma reesei (generic).

* * * * *
    (b) * * *
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
725.950(b)(2) through (4) and a requirement to maintain records 
documenting compliance with limitations in paragraph (a)(2) are 
applicable to manufacturers and processors of this microorganism.
    (2) Modification or revocation of certain notification 
requirements. The provisions of Sec.  725.984 apply to this section.

[FR Doc. 2026-22888 Filed 11-9-26; 8:45 am]
BILLING CODE 6560-50-P


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