Dimethyl Sulfoxide in Pesticide Formulations; Exemptions From the Requirement of a Tolerance

Issuing agencies

Abstract

This regulation establishes exemptions from the requirement of a tolerance for residues of dimethyl sulfoxide (CAS Reg. No. 67-68-5) when used as an inert ingredient (solvent/cosolvent) in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest, in pesticide formulations applied to animals, and in antimicrobial formulations applied to food-contact surfaces in public eating places, dairy-processing equipment, and food- processing equipment and utensils. Spring Regulatory Sciences on behalf of Gaylord Chemical Company, LLC submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment of exemptions from the requirement of a tolerance. This regulation eliminates the need to establish maximum permissible levels for residues of dimethyl sulfoxide when used in accordance with the terms of those exemptions.

Full Text

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<title>Federal Register, Volume 91 Issue 209 (Friday, October 30, 2026)</title>
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[Federal Register Volume 91, Number 209 (Friday, October 30, 2026)]
[Rules and Regulations]
[Pages 68480-68484]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-22176]


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ENVIRONMENTAL PROTECTION AGENCY

40 CFR Part 180

[EPA-HQ-OPP-2026-0529; FRL-13642-01-OCSPP]


Dimethyl Sulfoxide in Pesticide Formulations; Exemptions From the 
Requirement of a Tolerance

AGENCY: Environmental Protection Agency (EPA).

ACTION: Final rule.

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SUMMARY: This regulation establishes exemptions from the requirement of 
a tolerance for residues of dimethyl sulfoxide (CAS Reg. No. 67-68-5) 
when used as an inert ingredient (solvent/cosolvent) in pesticide 
formulations applied to growing crops or to raw agricultural 
commodities after harvest, in pesticide formulations applied to 
animals, and in antimicrobial formulations applied to food-contact 
surfaces in public eating places, dairy-processing equipment, and food-
processing equipment and utensils. Spring Regulatory Sciences on behalf 
of Gaylord Chemical Company, LLC submitted a petition to EPA under the 
Federal Food, Drug, and Cosmetic Act (FFDCA), requesting establishment 
of exemptions from the requirement of a tolerance. This regulation 
eliminates the need to establish maximum permissible levels for 
residues of dimethyl sulfoxide when used in accordance with the terms 
of those exemptions.

DATES: This regulation is effective October 30, 2026. Objections and 
requests for hearings must be received on or before December 29, 2026 
and must be filed in accordance with the instructions provided in 40 
CFR part 178 (see also Unit I.C. of this document).

ADDRESSES: The docket for this action, identified by docket 
identification (ID) number EPA-HQ-OPP-2026-0529, is available online at 
<a href="https://www.regulations.gov">https://www.regulations.gov</a>. Additional information about dockets 
generally, along with instructions for visiting the docket in-person, 
is available at <a href="https://www.epa.gov/dockets">https://www.epa.gov/dockets</a>.

FOR FURTHER INFORMATION CONTACT: Charles Smith, Registration Division 
(7505T), Office of Pesticide Programs, Environmental Protection Agency, 
1200 Pennsylvania Ave. NW, Washington, DC 20460-0001; main telephone 
number: (202) 566-1030; email address: <a href="/cdn-cgi/l/email-protection#d2809694809cbda6bbb1b7a192b7a2b3fcb5bda4"><span class="__cf_email__" data-cfemail="95c7d1d3c7dbfae1fcf6f0e6d5f0e5f4bbf2fae3">[email&#160;protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. General Information

A. Does this action apply to me?

    You may be potentially affected by this action if you are an 
agricultural producer, food manufacturer, or pesticide manufacturer. 
The following list of North American Industrial Classification System 
(NAICS) codes is not intended to be exhaustive, but rather provides a 
guide to help readers determine whether this document applies to them.
    <bullet> Crop production (NAICS code 111).
    <bullet> Animal production (NAICS code 112).
    <bullet> Food manufacturing (NAICS code 311).
    <bullet> Pesticide manufacturing (NAICS code 32532).
    If you have any questions regarding the applicability of this 
proposed action to a particular entity, consult the person listed under 
FOR FURTHER INFORMATION CONTACT.

B. What is EPA's authority for taking this action?

    EPA is issuing this rulemaking under section 408 of the Federal 
Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a. FFDCA section 
408(c)(2)(A)(i) allows EPA to establish an exemption from the 
requirement for a tolerance (the legal limit for a pesticide chemical 
residue in or on a food) only if EPA determines that the exemption is 
``safe.'' FFDCA section 408(c)(2)(A)(ii) defines ``safe'' to mean that 
``there is a reasonable certainty that no harm will result from 
aggregate exposure to the pesticide chemical residue, including all 
anticipated dietary exposures and all other exposures for which there 
is reliable information.'' This includes exposure through drinking 
water and in residential settings but does not include occupational 
exposure. Pursuant to FFDCA section 408(c)(2)(B), in establishing or 
maintaining in effect an exemption from the requirement of a tolerance, 
EPA must take into account the factors set forth in FFDCA section 
408(b)(2)(C), which require EPA to give special consideration to 
exposure of infants and children to the pesticide chemical residue in 
establishing a tolerance and to ``ensure that there is a reasonable 
certainty that no harm will result to infants and children from 
aggregate exposure to the pesticide chemical residue. . . .'' 
Additionally, FFDCA section 408(b)(2)(D) requires that the Agency 
consider, among other things, ``available information concerning the 
cumulative effects of a particular pesticide's residues'' and ``other 
substances that have a common mechanism of toxicity.''

[[Page 68481]]

C. How can I file an objection or hearing request?

    Under FFDCA section 408(g), 21 U.S.C. 346a(g), any person may file 
an objection to any aspect of this regulation and may also request a 
hearing on those objections. If you fail to file an objection to the 
final rule within the time period specified in the final rule, you will 
have waived the right to raise any issues resolved in the final rule. 
You must file your objection or request a hearing on this regulation in 
accordance with the instructions provided in 40 CFR part 178. To ensure 
proper receipt by EPA, you must identify the docket ID number EPA-HQ-
OPP-2026-0529 in the subject line on the first page of your submission. 
All objections and requests for a hearing must be in writing and must 
be received by the Hearing Clerk on or before December 29, 2026.
    EPA's Administrative Law Judges Division (ALJD), in which the 
Hearing Clerk is housed, urges parties to file and serve documents by 
electronic means only, notwithstanding any other particular 
requirements set forth in other procedural rules governing those 
proceedings. See ``Order Urging Electronic Filing and Service,'' dated 
December 3, 2025, which can be found at <a href="https://www.epa.gov/system/files/documents/2025-12/2025-12-03-order-urging-electronic-filing-and-service.pdf">https://www.epa.gov/system/files/documents/2025-12/2025-12-03-order-urging-electronic-filing-and-service.pdf</a>. Although EPA's regulations require submission via U.S. 
Mail or hand delivery, EPA intends to treat submissions filed via 
electronic means as properly filed submissions; therefore, EPA believes 
the preference for submission via electronic means will not be 
prejudicial. When submitting documents to the ALJD electronically, a 
person should utilize the e-filing system at <a href="https://yosemite.epa.gov/oa/eab/eab-alj_upload.nsf">https://yosemite.epa.gov/oa/eab/eab-alj_upload.nsf</a>.
    In addition to filing an objection or hearing request with the 
Hearing Clerk as described in 40 CFR part 178, please submit a copy of 
the filing (excluding any Confidential Business Information (CBI)) for 
inclusion in the public docket at <a href="https://www.regulations.gov">https://www.regulations.gov</a>. Follow 
the online instructions for submitting comments. Do not submit 
electronically any information you consider to be CBI or other 
information whose disclosure is restricted by statute. If you wish to 
include CBI in your request, please follow the applicable instructions 
at <a href="https://www.epa.gov/dockets/commenting-epa-dockets#rules">https://www.epa.gov/dockets/commenting-epa-dockets#rules</a> and clearly 
mark the information that you claim to be CBI. Information not marked 
confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA 
without prior notice.

II. Petition for Exemption

    In the Federal Register of June 15, 2026 (91 FR 35936, FRL-13201-
02-OCSPP), EPA issued a document pursuant to FFDCA section 408, 21 
U.S.C. 346a, announcing the filing of a pesticide petition (PP IN-
12546) by Spring Regulatory Sciences (6620 Cypresswood Dr., Suite 250, 
Spring, TX 77379) on behalf of Gaylord Chemical Company, LLC (106 
Galeria Boulevard, Slidell, LA 70458). The petition requested that EPA 
establish exemptions from the requirement of a tolerance for residues 
of dimethyl sulfoxide (CAS Reg. No. 67-68-5) when used as an inert 
ingredient (solvent/co-solvent) in pesticide formulations applied to 
growing crops or to raw agricultural commodities after harvest under 40 
CFR 180.910, in pesticide formulations applied to animals under 40 CFR 
180.930, and in antimicrobial formulations applied to food-contact 
surfaces in public eating places, dairy-processing equipment, and food-
processing equipment and utensils under 40 CFR 180.940(a). That 
document referenced a summary of the petition prepared by Spring 
Regulatory Sciences on behalf of Gaylord Chemical Company, LLC, which 
is available in the docket. There were no relevant comments received in 
response to the notice of filing.

III. Inert Ingredient Definition

    Inert ingredients are all ingredients that are not active 
ingredients as defined in 40 CFR 153.125 and include, but are not 
limited to, the following types of ingredients (except when they have a 
pesticidal efficacy of their own): solvents such as alcohols and 
hydrocarbons; surfactants such as polyoxyethylene polymers and fatty 
acids; carriers such as clay and diatomaceous earth; thickeners such as 
carrageenan and modified cellulose; wetting, spreading, and dispersing 
agents; propellants in aerosol dispensers; microencapsulating agents; 
and emulsifiers. The term ``inert'' is not intended to imply 
nontoxicity; the ingredient may or may not be chemically active. 
Generally, EPA has exempted inert ingredients from the requirement of a 
tolerance based on the low toxicity of the individual inert 
ingredients.

IV. Aggregate Risk Assessment and Determination of Safety

    EPA establishes exemptions from the requirement of a tolerance only 
in those cases where it can be clearly demonstrated that the risks from 
aggregate exposure to pesticide chemical residues under reasonably 
foreseeable circumstances will pose no harm to human health. In order 
to determine the risks from aggregate exposure to pesticide inert 
ingredients, the Agency considers the toxicity of the inert in 
conjunction with possible exposure to residues of the inert ingredient 
through food, drinking water, and through other exposures that occur as 
a result of pesticide use in residential settings. If EPA is able to 
determine that a finite tolerance is not necessary to ensure that there 
is a reasonable certainty that no harm will result from aggregate 
exposure to the inert ingredient, an exemption from the requirement of 
a tolerance may be established.
    Consistent with FFDCA section 408(c)(2)(A), and the factors 
specified in FFDCA section 408(c)(2)(B), EPA has reviewed the available 
scientific data and other relevant information in support of this 
action. EPA has sufficient data to assess the hazards of and to make a 
determination on aggregate exposure for dimethyl sulfoxide, including 
exposure resulting from the exemptions established by this action. 
EPA's assessment of exposures and risks associated with dimethyl 
sulfoxide follows.

A. Toxicological Profile

    EPA has evaluated the available toxicity data and considered their 
validity, completeness, and reliability as well as the relationship of 
the results of the studies to human risk. EPA has also considered 
available information concerning the variability of the sensitivities 
of major identifiable subgroups of consumers, including infants and 
children. Specific information on the studies received and the nature 
of the adverse effects caused by dimethyl sulfoxide as well as the no-
observed-adverse-effect-level (NOAEL) and the lowest-observed-adverse-
effect-level (LOAEL) from the toxicity studies are discussed in this 
unit.
    Dimethyl sulfoxide has low acute toxicity via the oral (lethal 
dose, LD<INF>50</INF> >7,920 mg/kg) and dermal (LD<INF>50</INF> >40,000 
mg/kg) routes, and the inhalation (lethal concentration, 
LC<INF>50</INF> >1,600 mg/m\3\) route. It is a dermal and eye irritant. 
It is a skin sensitizer.
    Overall systemic toxicity is low for dimethyl sulfoxide. The target 
organ of toxicity is the eye in repeated-dose oral and dermal toxicity 
studies in rats, dogs, and rabbits. Changes in the lens of the eyes 
such as refractile changes and composition are seen in animals above 
the limit dose of 1,000 mg/kg/day. Portal of entry effects (respiratory 
tract irritation) are observed in a subchronic

[[Page 68482]]

inhalation toxicity study at 2.783 mg/L (above the limit dose 1 mg/L) 
in rats. Maternal toxicity (reduced food consumption and body weight 
gain) is observed at 1,000 mg/kg/day in a developmental toxicity study 
in rabbits. No maternal or reproductive toxicity is seen in the 
reproduction/developmental toxicity screening test in rats at 1,000 mg/
kg/day. Also, no developmental or offspring toxicity is seen in these 
studies; therefore, there is no concern for fetal susceptibility. The 
concern for carcinogenicity is low, based on cancer initiation/
promotion studies and negative results in mutagenicity studies. No 
evidence of neurotoxicity or immunotoxicity is observed in the 
available studies.

B. Toxicological Points of Departure/Levels of Concern

    Once a pesticide's toxicological profile is determined, EPA 
identifies toxicological points of departure (POD) and levels of 
concern to use in evaluating the risk posed by human exposure to the 
pesticide. For hazards that have a threshold below which there is no 
appreciable risk, the toxicological POD is used as the basis for 
derivation of reference values for risk assessment. PODs are developed 
based on a careful analysis of the doses in each toxicological study to 
determine the NOAEL and the LOAEL. Uncertainty/safety factors are used 
in conjunction with the POD to calculate a safe exposure level, 
generally referred to as a population-adjusted dose or a reference 
dose, and a safe margin of exposure. For non-threshold risks, the 
Agency assumes that any amount of exposure will lead to some degree of 
risk. Thus, the Agency estimates risk in terms of the probability of an 
occurrence of the adverse effect expected in a lifetime. For more 
information on the general principles EPA uses in risk characterization 
and a complete description of the risk assessment process, see <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/overview-risk-assessment-pesticide-program">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/overview-risk-assessment-pesticide-program</a>.
    The hazard profile of dimethyl sulfoxide is adequately defined. 
Overall, dimethyl sulfoxide is of low acute, subchronic, and 
developmental toxicity. Systemic toxicity is observed only at doses 
>=1,100 mg/kg/day. Since no toxicological endpoints of concern or PODs 
were identified, EPA conducted a qualitative risk assessment for 
dimethyl sulfoxide.

C. Exposure Assessment

1. Dietary Exposure From Food and Feed Uses
    In evaluating dietary exposure to dimethyl sulfoxide, EPA 
considered exposure under the existing and proposed exemptions from the 
requirement of a tolerance. EPA assessed dietary exposures from 
dimethyl sulfoxide in food as follows.
    Dietary exposure (food and drinking water) to dimethyl sulfoxide 
may occur following ingestion of foods with residues from use in 
accordance with these exemptions. However, a quantitative dietary 
exposure assessment was not conducted since a toxicological endpoint 
for risk assessment was not identified.
2. From Non-Dietary Exposure
    The term ``residential exposure'' is used in this document to refer 
to non-occupational, non-dietary exposure (e.g., textiles (clothing and 
diapers), carpets, swimming pools, and hard surface disinfection on 
walls, floors, and tables).
    Dimethyl sulfoxide may be present in pesticide and non-pesticide 
products that may be used in and around the home. However, a 
quantitative residential exposure assessment was not conducted since a 
toxicological endpoint for risk assessment was not identified.
3. Cumulative Effects From Substances With a Common Mechanism of 
Toxicity
    Section 408(b)(2)(D)(v) of FFDCA requires that, when considering 
whether to establish, modify, or revoke a tolerance, the Agency 
consider ``available information'' concerning the cumulative effects of 
a particular pesticide's residues and ``other substances that have a 
common mechanism of toxicity.''
    Based on the lack of toxicity in the available database, EPA has 
not found dimethyl sulfoxide to share a common mechanism of toxicity 
with any other substances, and dimethyl sulfoxide does not appear to 
produce a toxic metabolite produced by other substances. For the 
purposes of these tolerance exemptions, therefore, EPA has assumed that 
dimethyl sulfoxide does not have a common mechanism of toxicity with 
other substances. For information regarding EPA's efforts to determine 
which chemicals have a common mechanism of toxicity and to evaluate the 
cumulative effects of such chemicals, see EPA's website at <a href="https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/cumulative-assessment-risk-pesticides">https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/cumulative-assessment-risk-pesticides</a>.

D. Additional Safety Factor for the Protection of Infants and Children

    Section 408(b)(2)(C) of FFDCA provides that EPA shall apply an 
additional tenfold (10X) margin of safety for infants and children in 
the case of threshold effects to account for prenatal and postnatal 
toxicity and the completeness of the database on toxicity and exposure 
unless EPA determines based on reliable data that a different margin of 
safety will be safe for infants and children. This additional margin of 
safety is commonly referred to as the Food Quality Protection Act 
safety factor. In applying this provision, EPA either retains the 
default value of 10X or uses a different additional safety factor when 
reliable data are available to EPA support the choice of a different 
factor.
    Based on an assessment of dimethyl sulfoxide, EPA has concluded 
that there are no toxicological endpoints of concern for the U.S. 
population, including infants and children. Because there are no 
threshold effects associated with dimethyl sulfoxide, EPA conducted a 
qualitative assessment. As part of that assessment, the Agency did not 
use safety factors for assessing risk, and no additional safety factor 
is needed for assessing risk to infants and children.

E. Aggregate Risks and Determination of Safety

    Because no toxicological endpoints of concern were identified, EPA 
concludes that there is a reasonable certainty that no harm will result 
to the general population, or to infants and children, from aggregate 
exposure to dimethyl sulfoxide residues.

F. Analytical Enforcement Methodology

    An analytical method is not required for enforcement purposes since 
the Agency is establishing an exemption from the requirement of a 
tolerance without any numerical limitation.

G. Conclusions

    Therefore, an exemption from the requirement of a tolerance is 
established for residues of dimethyl sulfoxide (CAS Reg. No. 67-68-5) 
when used as an inert ingredient (solvent/co-solvent) in pesticide 
formulations applied to growing crops and raw agricultural commodities 
after harvest under 40 CFR 180.910, in pesticide formulations applied 
to animals under 40 CFR 180.930, and in antimicrobial formulations 
applied to food-contact surfaces in public eating places, dairy-
processing equipment, and food-processing equipment and utensils under 
40 CFR 180.940(a).

[[Page 68483]]

V. Statutory and Executive Order Reviews

    Additional information about these statutes and Executive Orders 
can be found at <a href="https://www.epa.gov/laws-regulations/laws-and-executive-orders">https://www.epa.gov/laws-regulations/laws-and-executive-orders</a>.

A. Executive Order 12866: Regulatory Planning and Review

    This action is exempt from review under Executive Order 12866 (58 
FR 51735, October 4, 1993), because it establishes or modifies a 
pesticide tolerance or a tolerance exemption under FFDCA section 408. 
The Office of Management and Budget (OMB) has exempted these types of 
actions from review under Executive Order 12866.

B. Executive Order 14192: Unleashing Prosperity Through Deregulation

    Executive Order 14192 (90 FR 9065, February 6, 2025) does not apply 
because actions that establish a tolerance exemption under FFDCA 
section 408 are exempted from review under Executive Order 12866.

C. Paperwork Reduction Act (PRA)

    This action does not impose an information collection burden under 
the PRA 44 U.S.C. 3501 et seq., because it does not contain any 
information collection activities.

D. Regulatory Flexibility Act (RFA)

    This action is not subject to the RFA, 5 U.S.C. 601 et seq. The RFA 
applies only to rules subject to notice and comment rulemaking 
requirements under the Administrative Procedure Act (APA), 5 U.S.C. 
553, or any other statute. This rule is not subject to the APA but is 
subject to FFDCA section 408(d), which does not require notice and 
comment rulemaking to take this action in response to a petition.

E. Unfunded Mandates Reform Act (UMRA)

    This action does not contain an unfunded mandate of $100 million or 
more (in 1995 dollars and adjusted annually for inflation) as described 
in UMRA, 2 U.S.C. 1531-1538, and does not significantly or uniquely 
affect small governments. The action imposes no enforceable duty on any 
state, local or tribal governments or the private sector.

F. Executive Order 13132: Federalism

    This action does not have federalism implications as specified in 
Executive Order 13132 (64 FR 43255, August 10, 1999), because it will 
not have substantial direct effects on the States, on the relationship 
between the National Government and the States, or on the distribution 
of power and responsibilities among the various levels of government.

G. Executive Order 13175: Consultation and Coordination With Indian 
Tribal Governments

    This action does not have Tribal implications as specified in 
Executive Order 13175 (65 FR 67249, November 9, 2000), because it will 
not have substantial direct effects on Tribal governments, on the 
relationship between the Federal Government and the Indian Tribes, or 
on the distribution of power and responsibilities between the Federal 
Government and Indian Tribes.

H. Executive Order 13045: Protection of Children From Environmental 
Health Risks and Safety Risks

    This action is not subject to Executive Order 13045 (62 FR 19885, 
April 23, 1997) because it is not a significant regulatory action under 
section 3(f)(1) of Executive Order 12866, and because EPA does not 
believe the environmental health or safety risks addressed by this 
action present a disproportionate risk to children.
    However, EPA's 2026 Policy on Children's Health applies to this 
action. This rule finalizes tolerance actions under the FFDCA, which 
requires EPA to give special consideration to exposure of infants and 
children to the pesticide chemical residue in establishing a tolerance 
and to ``ensure that there is a reasonable certainty that no harm will 
result to infants and children from aggregate exposure to the pesticide 
chemical residue . . .'' (FFDCA 408(b)(2)(C)). The Agency's 
consideration is documented in the pesticide-specific review documents, 
located in the applicable docket at <a href="https://www.regulations.gov">https://www.regulations.gov</a>.

I. Executive Order 13211: Actions Concerning Regulations That 
Significantly Affect Energy Supply, Distribution or Use

    This action is not subject to Executive Order 13211 (66 FR 28355) 
(May 22, 2001) because it is not a significant regulatory action under 
Executive Order 12866.

J. National Technology Transfer Advancement Act (NTTAA)

    This action does not involve technical standards that would require 
Agency consideration under NTTAA section 12(d), 15 U.S.C. 272.

K. Congressional Review Act (CRA)

    This action is subject to the CRA, 5 U.S.C. 801 et seq., and EPA 
will submit a rule report to each House of the Congress and to the 
Comptroller General of the United States. This action is not a ``major 
rule'' as defined by 5 U.S.C. 804(2).

List of Subjects in 40 CFR Part 180

    Environmental protection, Administrative practice and procedure, 
Agricultural commodities, Pesticides and pests, Reporting and 
recordkeeping requirements.

    Dated: October 26, 2026.
Charles Smith,
Director, Registration Division, Office of Pesticide Programs.

    For the reasons stated in the preamble, the EPA amends 40 CFR 
chapter I as follows:

PART 180--TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES 
IN FOOD

0
1. The authority citation for part 180 continues to read as follows:

    Authority:  21 U.S.C. 321(q), 346a and 371.


0
2. In Sec.  180.910, amend Table 1 to Sec.  180.910 by adding, in 
alphabetical order, an entry for ``Dimethyl sulfoxide (CAS Reg. No. 67-
68-5)'' to read as follows:


Sec.  180.910  Inert ingredients used pre- and post-harvest; exemptions 
from the requirement of a tolerance.

* * * * *

                           Table 1 to 180.910
------------------------------------------------------------------------
       Inert ingredients              Limits                Uses
------------------------------------------------------------------------
 
                              * * * * * * *
Dimethyl sulfoxide (CAS Reg.    None.............  Solvent/Co-solvent.
 No. 67-68-5).
 
                              * * * * * * *
------------------------------------------------------------------------


[[Page 68484]]


0
3. In Sec.  180.930, amend Table 1 to Sec.  180.930 by adding, in 
alphabetical order, an entry for ``Dimethyl sulfoxide (CAS Reg. No. 67-
68-5)'' to read as follows:


Sec.  180.930  Inert ingredients applied to animals; exemptions from 
the requirement of a tolerance.

* * * * *

                           Table 1 to 180.930
------------------------------------------------------------------------
        Inert ingredients               Limits               Uses
------------------------------------------------------------------------
 
                              * * * * * * *
Dimethyl sulfoxide (CAS Reg. No.  None..............  Solvent/Co-
 67-68-5).                                             solvent.
------------------------------------------------------------------------

* * * * *

0
4. In Sec.  180.940, amend Table 1 to Paragraph (a) by adding, in 
alphabetical order, an entry for ``Dimethyl sulfoxide'' to read as 
follows:


Sec.  180.940  Tolerance exemptions for active and inert ingredients 
for use in antimicrobial formulations (Food-contact surface sanitizing 
solutions)

* * * * *
    (a) * * *

                        Table 1 to Paragraph (a)
------------------------------------------------------------------------
         Inert ingredients           CAS Reg. No.          Limits
------------------------------------------------------------------------
 
                              * * * * * * *
Dimethyl sulfoxide................         67-68-5  Solvent/Co-solvent.
 
                              * * * * * * *
------------------------------------------------------------------------

* * * * *
[FR Doc. 2026-22176 Filed 10-29-26; 8:45 am]
BILLING CODE 6560-50-P


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