Schedules of Controlled Substances: Placement of O-Desmethyltramadol in Schedule I; Correction

Issuing agencies

Abstract

On August 12, 2026, the Drug Enforcement Administration (DEA) published a temporary order placing O-desmethyltramadol (other names: O-DSMT; desmetramadol; 3-[(1R,2R)-2-[(dimethylamino)methyl]-1- hydroxycyclohexyl]phenol), including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers are possible, in schedule I of the Controlled Substances Act. DEA published this temporary order that specifically noted in the summary that the control of O-desmethyltramadol included its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers are possible, however inadvertently omitted the correct language that should have been included. This document corrects that error, adding the correct language.

Full Text

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<title>Federal Register, Volume 91 Issue 195 (Friday, October 9, 2026)</title>
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[Federal Register Volume 91, Number 195 (Friday, October 9, 2026)]
[Rules and Regulations]
[Pages 64617-64618]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-20748]


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DEPARTMENT OF JUSTICE

Drug Enforcement Administration

21 CFR Part 1308

[Docket No. DEA-1641]


Schedules of Controlled Substances: Placement of O-
Desmethyltramadol in Schedule I; Correction

AGENCY: Drug Enforcement Administration, Department of Justice.

ACTION: Correcting amendment.

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SUMMARY: On August 12, 2026, the Drug Enforcement Administration (DEA) 
published a temporary order placing O-desmethyltramadol (other names: 
O-DSMT; desmetramadol; 3-[(1R,2R)-2-[(dimethylamino)methyl]-1-
hydroxycyclohexyl]phenol), including its salts, isomers, and salts of 
isomers whenever the existence of such salts, isomers, and salts of 
isomers are possible, in schedule I of the Controlled Substances Act. 
DEA published this temporary order that specifically noted in the 
summary that the control of O-desmethyltramadol included its salts, 
isomers, and salts of isomers whenever the existence of such salts, 
isomers, and salts of isomers are possible, however inadvertently 
omitted the correct language that should have been included. This 
document corrects that error, adding the correct language.

DATES: This correcting amendment is effective October 9, 2026, until 
August 12, 2028, and applicable beginning August 12, 2026.

FOR FURTHER INFORMATION CONTACT: Dr. Terrence L. Boos, Drug and 
Chemical Evaluation Section, Diversion Control Division, Drug 
Enforcement Administration; Telephone: (571) 362-3249.

SUPPLEMENTARY INFORMATION: The placement of O-desmethyltramadol under 
schedule I was effective on August 12, 2026.\1\ After publication of 
the temporary scheduling order, DEA inadvertently omitted the correct 
language that should have been included in 21 CFR part 1308. This 
document corrects the language in 21 CFR part 1308 to include the 
isomers, esters, ethers, salts, and salts of isomers, esters and 
ethers, whenever the existence of such isomers, esters, ethers and 
salts is possible of O-desmethyltramadol.
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    \1\ Schedules of Controlled Substances: Temporary Placement of 
O-desmethyltramadol in Schedule I, 91 FR 52013 (Aug. 12, 2026).
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List of Subjects in 21 CFR Part 1308

    Administrative practice and procedure, Drug traffic control, 
Reporting and recordkeeping requirements.

    For the reasons set out above, DEA corrects 21 CFR part 1308 with 
the following correcting amendment:

PART 1308--SCHEDULES OF CONTROLLED SUBSTANCES

0
1. The authority citation for part 1308 continues to read as follows:

    Authority:  21 U.S.C. 811, 812, 871(b), 956(b), unless otherwise 
noted.


0
2. In Sec.  1308.11, revise paragraph (h)(88) to read as follows:


Sec.  1308.11  Schedule I.

* * * * *
    (h) * * *

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                              * * * * * * *
(88) O-desmethyltramadol, its isomers, esters, ethers, salts,       9667
 and salts of isomers, esters and ethers (other names: O-DSMT;
 desmetramadol; 3-[(1R,2R)-2-[(dimethylamino)methyl]-1-
 hydroxycyclohexyl]phenol).....................................
 
                              * * * * * * *
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[[Page 64618]]

Signing Authority

    This document of the Drug Enforcement Administration was signed on 
October 6, 2026, by DEA Administrator Terrance C. Cole. That document 
with the original signature and date is maintained by DEA. For 
administrative purposes only, and in compliance with requirements of 
the Office of the Federal Register, the undersigned DEA Federal 
Register Liaison Officer has been authorized to sign and submit the 
document in electronic format for publication, as an official document 
of DEA. This administrative process in no way alters the legal effect 
of this document upon publication in the Federal Register.

Heather Achbach,
Federal Register Liaison Officer, Drug Enforcement Administration.
[FR Doc. 2026-20748 Filed 10-8-26; 8:45 am]
BILLING CODE 4410-09-P


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