Availability of Two Draft Toxicological Profiles

Issuing agencies

Abstract

The Agency for Toxic Substances and Disease Registry (ATSDR), within the Department of Health and Human Services (HHS), announces the opening of a docket to obtain comments on a draft of the updated Toxicological Profiles for Cadmium and Hexachlorocyclopentadiene. This action provides an opportunity for the public and organizations to submit comments on drafts of the profiles. In particular, ATSDR is interested in any relevant additional information, data, research studies, or reports on the health effects caused by exposure to the substances covered in the profiles for review.

Full Text

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[Federal Register Volume 91, Number 189 (Thursday, October 1, 2026)]
[Notices]
[Pages 62518-62519]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-20068]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[Docket No. ATSDR-2026-0133]


Availability of Two Draft Toxicological Profiles

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice with comment period.

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SUMMARY: The Agency for Toxic Substances and Disease Registry (ATSDR), 
within the Department of Health and Human Services (HHS), announces the 
opening of a docket to obtain comments on a draft of the updated 
Toxicological Profiles for Cadmium and Hexachlorocyclopentadiene. This 
action provides an opportunity for the public and organizations to 
submit comments on drafts of the profiles. In particular, ATSDR is 
interested in any relevant additional information, data, research 
studies, or reports on the health effects caused by exposure to the 
substances covered in the profiles for review.

DATES: Written comments must be received on or before December 30, 
2026.

ADDRESSES: You may submit comments, identified by Docket No. ATSDR-
2026-

[[Page 62519]]

0133 by either of the methods listed below. Do not submit comments by 
email. ATSDR does not accept comments by email.
    <bullet> Federal eRulemaking Portal: <a href="http://www.regulations.gov">http://www.regulations.gov</a>. 
Follow the instructions for submitting comments.
    <bullet> Mail: Agency for Toxic Substances and Disease Registry, 
Office of Innovation and Analytics, 4770 Buford Highway, Mail Stop 
S106-5, Atlanta, GA, 30341-3717. Attn: Docket No. ATSDR-2026-0133.
    Instructions: All submissions received must include the agency name 
and Docket Number. All relevant comments received will be posted 
without change to <a href="http://www.regulations.gov">http://www.regulations.gov</a>, including any personal 
information provided. For access to the docket to read background 
documents or comments received, go to <a href="http://www.regulations.gov">http://www.regulations.gov</a>.

FOR FURTHER INFORMATION CONTACT: Robert Robinson, Agency for Toxic 
Substances and Disease Registry, Office of Innovation and Analytics, 
4770 Buford Highway, Mail Stop S106-5, Atlanta, GA, 30341-3717; Email: 
<a href="/cdn-cgi/l/email-protection#0f4e5b5c4b5d5b60775f7d606966636a495d417c4f6c6b6c21686079"><span class="__cf_email__" data-cfemail="cc8d989f889e98a3b49cbea3aaa5a0a98a9e82bf8cafa8afe2aba3ba">[email&#160;protected]</span></a>; Phone: 1-800-232-4636.

SUPPLEMENTARY INFORMATION: ATSDR has prepared a draft of the updated 
Toxicological Profiles for Cadmium and Hexachlorocyclopentadiene based 
on current understanding of the health effects and availability of new 
studies and other information since its initial release. All 
toxicological profiles issued as ``Drafts for Public Comment'' 
represent the result of ATSDR's evidence-based evaluations of the 
available literature to provide important toxicological information on 
priority hazardous substances to the public and health professionals. 
ATSDR considers key studies for these substances during the profile 
development process, using a systematic review approach. To that end, 
ATSDR is seeking public comments and additional information, data, 
research studies or reports on the health effects of these substances. 
ATSDR will evaluate the quality and relevance of such data or studies 
for possible inclusion in the profile.

Legislative Background

    The Superfund Amendments and Reauthorization Act of 1986 (SARA) (42 
U.S.C. 9601 et seq.) amended the Comprehensive Environmental Response, 
Compensation, and Liability Act of 1980 (CERCLA or Superfund) (42 
U.S.C. 9601 et seq.) by establishing certain requirements for ATSDR and 
the U.S. Environmental Protection Agency (EPA) regarding the hazardous 
substances most commonly found at facilities on the CERCLA National 
Priorities List. Among these statutory requirements is a mandate for 
the Administrator of ATSDR to prepare toxicological profiles for each 
substance included on the priority list of hazardous substances (also 
called the Substance Priority List (SPL)). This list identifies 275 
hazardous substances that ATSDR has determined pose the most 
significant potential threat to human health. The SPL is available 
online at <a href="https://www.atsdr.cdc.gov/programs/substance-priority-list.html">https://www.atsdr.cdc.gov/programs/substance-priority-list.html</a>. ATSDR is also mandated to revise and publish updated 
toxicological profiles, as necessary, to reflect updated health effects 
and other information.
    In addition, CERCLA provides ATSDR with the authority to prepare 
toxicological profiles for substances not found on the SPL. CERCLA 
authorizes ATSDR to establish and maintain an inventory of literature, 
research, and studies on the health effects of toxic substances (CERCLA 
section 104(i)(1)(B); 42 U.S.C. 9604(i)(1)(B)); to respond to requests 
for health consultations (CERCLA section 104(i)(4); 42 U.S.C. 
9604(i)(4)); and to support the site-specific response actions 
conducted by the agency (CERCLA section 104(i)(6); 42 U.S.C. 
9604(i)(6)).

Availability

    The draft toxicological profiles are available online at <a href="http://www.regulations.gov">http://www.regulations.gov</a>, Docket No. ATSDR-2026-0133 and at <a href="https://www.atsdr.cdc.gov/toxicological-profiles/about/index.html">https://www.atsdr.cdc.gov/toxicological-profiles/about/index.html</a>.

Public Participation

    Interested people or organizations are invited to participate by 
submitting written views, recommendations, and data. Please note that 
comments received, including attachments and other supporting 
materials, are part of the public record and are subject to public 
disclosure. Comments will be posted on <a href="https://www.regulations.gov">https://www.regulations.gov</a>. 
Therefore, do not include any information in your comment or supporting 
materials that you consider confidential or inappropriate for public 
disclosure. If you include your name, contact information, or other 
information that identifies you in the body of your comments, that 
information will be on public display. ATSDR will review all 
submissions and may choose to redact, or withhold, submissions 
containing private or proprietary information such as Social Security 
numbers, medical information, inappropriate language, or duplicate/near 
duplicate examples of a mass-mail campaign. If you submit comments with 
reference to studies that are not publicly available such as 
unpublished research, those studies must be attached with your comment 
for review. Otherwise ATSDR may be unable to respond to portions of 
your comment referring to any material that is not publicly available. 
Do not submit comments by email. ATSDR does not accept comments by 
email. Please note that we will not be able to accommodate extension 
requests because it would not allow the agency to proceed with timely 
finalization of the document.

Donata Green,
Associate Director, Office of Policy, Planning and Partnerships, Agency 
for Toxic Substances and Disease Registry.
[FR Doc. 2026-20068 Filed 9-30-26; 8:45 am]
BILLING CODE 4163-70-P


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