Significant New Use Rules on Certain Chemical Substances (24-5.5e)

Issuing agencies

Abstract

EPA is issuing significant new use rules (SNURs) under the Toxic Substances Control Act (TSCA) for certain chemical substances that were the subject of premanufacture notices (PMNs) and are also subject to an Order issued by EPA pursuant to TSCA. The SNURs require persons to notify EPA at least 90 days before commencing the manufacture (defined by statute to include import) or processing of any of these chemical substances for an activity that is designated as a significant new use in the SNUR. The required notification initiates EPA's evaluation of the conditions of that use for that chemical substance. In addition, the manufacture or processing for the significant new use may not commence until EPA has conducted a review of the required notification; made an appropriate determination regarding that notification; and taken such actions as required by that determination.

Full Text

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<title>Federal Register, Volume 91 Issue 164 (Wednesday, August 26, 2026)</title>
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[Federal Register Volume 91, Number 164 (Wednesday, August 26, 2026)]
[Rules and Regulations]
[Pages 54992-55007]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-17400]


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ENVIRONMENTAL PROTECTION AGENCY

40 CFR Part 721

[EPA-HQ-OPPT-2024-0281; FRL-12742-02-OCSPP]
RIN 2070-AB27


Significant New Use Rules on Certain Chemical Substances (24-
5.5e)

AGENCY: Environmental Protection Agency (EPA).

ACTION: Final rule.

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SUMMARY: EPA is issuing significant new use rules (SNURs) under the 
Toxic Substances Control Act (TSCA) for certain chemical substances 
that were the subject of premanufacture notices (PMNs) and are also 
subject to an Order issued by EPA pursuant to TSCA. The SNURs require 
persons to notify EPA at least 90 days before commencing the 
manufacture (defined by statute to include import) or processing of any 
of these chemical substances for an activity that is designated as a 
significant new use in the SNUR. The required notification initiates 
EPA's evaluation of the conditions of that use for that chemical 
substance. In addition, the manufacture or processing for the 
significant new use may not commence until EPA has conducted a review 
of the required notification; made an appropriate determination 
regarding that notification; and taken such actions as required by that 
determination.

DATES: This rule is effective on October 26, 2026. For purposes of 
judicial review, this rule shall be promulgated at 1 p.m. (EST) on 
September 9, 2026.

ADDRESSES: The docket for this action, identified under docket 
identification (ID) number EPA-HQ-OPPT-2024-0281, is available online 
at <a href="https://www.regulations.gov">https://www.regulations.gov</a> or in person at the Office of Pollution 
Prevention and Toxics Docket (OPPT Docket) in the Environmental 
Protection Agency Docket Center (EPA/DC). Please review the visitor 
instructions and additional information about the docket available at 
<a href="https://www.epa.gov/dockets">https://www.epa.gov/dockets</a>.

FOR FURTHER INFORMATION CONTACT: 
    For technical information: Andrew Sullivan, New Chemicals Division 
(7405M), Office of Pollution Prevention and Toxics, Environmental 
Protection Agency, 1200 Pennsylvania Ave. NW, Washington, DC 20460-
0001; telephone number: (202) 564-0605; email address: 
<a href="/cdn-cgi/l/email-protection#0b787e6767627d6a65256a656f796e7c4b6e7b6a256c647d"><span class="__cf_email__" data-cfemail="b0c3c5dcdcd9c6d1de9ed1ded4c2d5c7f0d5c0d19ed7dfc6">[email&#160;protected]</span></a>.
    For general information on SNURs: Iliriana Mushkolaj, New Chemicals 
Division (7405M), Office of Pollution Prevention and Toxics, 
Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, 
DC 20460-0001; telephone number: (202) 564-6877; email address: 
<a href="/cdn-cgi/l/email-protection#036e76706b686c6f62692d6a6f6a716a626d62436673622d646c75"><span class="__cf_email__" data-cfemail="3e534b4d565551525f54105752574c575f505f7e5b4e5f10595148">[email&#160;protected]</span></a>.
    For general information on TSCA: The TSCA Assistance Information 
Service Hotline, Goodwill of the Finger Lakes, 422 South Clinton Ave., 
Rochester, NY 14620; telephone number: (800) 471-7127 or (202) 554-
1404; email address: <a href="/cdn-cgi/l/email-protection#7b2f28383a5633140f1712151e3b1e0b1a551c140d"><span class="__cf_email__" data-cfemail="2f7b7c6c6e0267405b4346414a6f4a5f4e01484059">[email&#160;protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. Executive Summary

A. What is the Agency's authority for taking this action?

    TSCA section 5(a)(2) (15 U.S.C. 2604(a)(2)) authorizes EPA to 
determine that a use of a chemical substance is a ``significant new 
use.'' EPA must make this determination by rule after considering all 
relevant factors, including the factors in TSCA section 5(a)(2).

B. What action is the Agency taking?

    EPA is finalizing SNURs under TSCA section 5(a)(2) for the chemical 
substances identified in this document. These chemical substances were 
the subject of PMNs and are also subject to an Order issued by EPA 
pursuant to TSCA section 5(e)(1)(A), as required by the determinations 
made under TSCA section 5(a)(3)(B). The SNURs identify as significant 
new uses any manufacturing, processing, use, distribution in commerce, 
or disposal that does not conform to the restrictions imposed by the 
underlying TSCA Orders, consistent with TSCA section 5(f)(4). The SNURs 
require persons who intend to manufacture or process any of these 
chemical substances for an activity that is designated as a significant 
new use in the SNURs to notify EPA at least 90 days before commencing 
that activity.
    Previously, EPA proposed SNURs for these chemical substances in the 
Federal Register of November 3, 2025 (90 FR 49148 (FRL-12742-01-
OCSPP)). The docket includes information considered by the Agency in 
developing the proposed and final rules, including public comments and 
EPA's responses to the comments received as discussed in Unit II.D.

C. Does this action apply to me?

1. General Applicability
    This action applies to you if you manufacture, process, or use the 
chemical substances identified in this document. The following list of 
North American Industrial Classification System (NAICS) codes is not 
intended to be exhaustive, but rather provides a guide to help readers 
determine whether this document applies to them. Potentially affected 
entities may include:
    <bullet> Manufacturers or processors of one or more subject 
chemical substances (NAICS codes 325 and 324110), e.g., chemical 
manufacturing and petroleum refineries.
2. Applicability to Importers and Exporters
    This action may also apply to certain entities through pre-existing 
import certification and export notification requirements under TSCA 
(<a href="https://www.epa.gov/tsca-import-export-requirements">https://www.epa.gov/tsca-import-export-requirements</a>).
    Chemical importers are subject to TSCA section 13 (15 U.S.C. 2612), 
the requirements in 19 CFR 12.118 through 12.127, 19 CFR 127.28, and 40 
CFR part 707, subpart B. Importers of chemical substances in bulk form, 
as part of a mixture, or as part of an article (if required by rule) 
must certify that the shipment of the chemical substance complies with 
all applicable rules and orders under TSCA, including regulations 
issued under TSCA sections 5, 6, 7 and Title IV.
    Pursuant to 40 CFR 721.20, any persons who export or intend to 
export a chemical substance identified in this document are subject to 
the export notification provisions of TSCA section 12(b) (15 U.S.C. 
2611(b)) and must comply with the export notification requirements in 
40 CFR part 707, subpart D.

D. What are the incremental economic impacts of this action?

    EPA has evaluated the potential costs of establishing SNUN 
reporting requirements for potential manufacturers and processors of 
the chemical substances identified in this document. This analysis, 
which is available in the docket, is briefly summarized here.
1. Estimated Costs for SNUN Submissions
    A SNUR requires that any person who intends to engage in such 
activity in the future must first notify EPA by

[[Page 54993]]

submitting a SNUN. If a SNUN is submitted, costs are an estimated 
$45,000 per SNUN submission for large business submitters and $14,500 
for small business submitters. These estimates include the cost to 
prepare and submit the SNUN (including registration for EPA's Central 
Data Exchange (CDX)), and the payment of a user fee. Businesses that 
submit a SNUN would be subject to either a $37,000 user fee required by 
40 CFR 700.45(c)(2)(ii) and (d), or, if they are a small business as 
defined at 13 CFR 121.201, a reduced user fee of $6,480 (40 CFR 
700.45(c)(1)(ii) and (d)). These estimates reflect the costs and fees 
as they are known at the time of this rulemaking.
2. Estimated Costs for Export Notifications
    EPA has also evaluated the potential costs associated with the pre-
existing export notification requirements under TSCA section 12(b) and 
the implementing regulations at 40 CFR part 707, subpart D. For persons 
exporting a substance that is the subject of a SNUR, a one-time notice 
to EPA must be provided for the first export or intended export to a 
particular country. The total costs of export notification will vary by 
chemical, depending on the number of required notifications (i.e., the 
number of countries to which the chemical is exported). While EPA is 
unable to make any estimate of the likely number of export 
notifications for the chemical substances covered by these SNURs, as 
stated in the accompanying economic analysis, the estimated cost of the 
export notification requirement on a per unit basis is approximately 
$106.

II. Background

A. General Information About SNURs

    Unit II. of the proposed rule provides general information about 
SNURs, and additional information about EPA's new chemical program is 
available at <a href="https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca">https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca</a>.

B. Applicability of the Significant New Use Designation

    To establish a significant new use, EPA must determine that the use 
is not ongoing. As discussed in Unit II.E. of the proposed rule, EPA 
concluded that the proposed significant new uses were not ongoing. If 
EPA subsequently determines that such a use was ongoing as of the date 
of publication of the proposed rule and did not cease prior to issuance 
of the final rule, EPA will not designate that use as a significant new 
use in the final rule. EPA has no information to suggest that any of 
the significant new uses identified in this rule meet this criterion.
    As discussed in the Federal Register of April 24, 1990 (55 FR 17376 
(FRL-3658-5)), EPA believes that the intent of TSCA section 5(a)(1)(B) 
is best served by designating a use as a significant new use as of the 
date of publication of the proposed rule rather than as of the 
effective date of the final rule. The objective of EPA's approach is to 
ensure that a person cannot impede finalization of a SNUR by initiating 
a significant new use after publication of the proposed rule but before 
the effective date of the final rule. Uses arising after the 
publication of the proposed rule are distinguished from uses that are 
identified in the final rule as having been ongoing on the date of 
publication of the proposed rule. The former would be new uses, the 
latter ongoing uses, except that uses that are identified as ongoing as 
of the publication of the proposed rule would not be considered ongoing 
uses if they have ceased by the date of issuance of a final rule.
    In the unlikely event that before a final rule becomes effective a 
person begins commercial manufacturing (including importing) or 
processing of the chemical substances for a use that is designated as a 
significant new use in that final rule, such a person would have to 
cease any such activity upon the effective date of the final rule. To 
resume their activities, these persons would have to first comply with 
all applicable SNUR notification requirements and wait until all TSCA 
prerequisites for the commencement of manufacture or processing have 
been satisfied.
    Issuance of a SNUR for a chemical substance does not signify that 
the chemical substance is listed on the TSCA Chemical Substance 
Inventory (TSCA Inventory). Guidance on how to determine if a chemical 
substance is on the TSCA Inventory is available on the internet at 
https://www.epa.gov/tsca-inventory.

C. Important Information About SNUN Submissions

1. SNUN Submissions
    SNUNs must be submitted on EPA Form No. 7710-25, generated using e-
PMN software, and submitted to the Agency in accordance with the 
procedures set forth in 40 CFR 720.40 and 721.25. E-PMN software is 
available electronically at <a href="https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca">https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca</a>.
2. Development and Submission of Information
    EPA recognizes that TSCA section 5 does not require development of 
any particular new information (e.g., generating test data) before 
submission of a SNUN. There is an exception: If a person is required to 
submit information for a chemical substance pursuant to a rule, order 
or consent agreement under TSCA section 4, then TSCA section 5(b)(1)(A) 
requires such information to be submitted to EPA at the time of 
submission of the SNUN.
    In the absence of a rule, TSCA order, or consent agreement under 
TSCA section 4 covering the chemical substance, persons are required 
only to submit information in their possession or control and to 
describe any other information known to or reasonably ascertainable by 
them (see 40 CFR 720.50). However, upon review of PMNs and SNUNs, the 
Agency has the authority to require appropriate testing. To assist with 
EPA's analysis of the SNUN, submitters are encouraged, but not 
required, to provide the potentially useful information as identified 
for the chemical substance in Unit III.C. of the proposed rule.
    EPA strongly encourages persons, before performing any testing, to 
consult with the Agency pertaining to protocol selection. Furthermore, 
pursuant to TSCA section 4(h), which pertains to reduction of testing 
in vertebrate animals, EPA encourages consultation with the Agency on 
the use of alternative test methods and strategies (also called New 
Approach Methodologies, or NAMs), if available, to generate the 
recommended test data. EPA encourages dialog with Agency 
representatives to help determine how best the submitter can meet both 
the data needs and the objective of TSCA section 4(h). For more 
information on alternative test methods and strategies to reduce 
vertebrate animal testing, visit <a href="https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce">https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce</a>.
    The potentially useful information described in Unit III. of the 
proposed rule may not be the only means of providing information to 
evaluate the chemical substance associated with the significant new 
uses. However, submitting a SNUN without any test data may increase the 
likelihood that EPA will take action under TSCA sections 5(e) or 5(f). 
EPA recommends that potential SNUN submitters contact EPA early enough 
so that they will be able to conduct the appropriate tests.

[[Page 54994]]

    SNUN submitters should be aware that EPA will be better able to 
evaluate SNUNs which provide detailed information about human exposure 
and environmental release that may result from the significant new use 
of the chemical substances.

D. Public Comments on Proposed Rule and EPA Responses

    EPA received public comments on the proposed SNURs and prepared a 
Response to Comment document that provides the Agency responses. The 
comments and the Response to Comment document are available in the 
docket. As described in the Response to Comment document, EPA is 
finalizing these SNURs with the following changes:
    <bullet> For P-18-281 and P-21-77 (40 CFR 721.12147), EPA is adding 
the exposure level threshold of 0.01 mg/m\3\ 8-hour time-weighted 
average (TWA) to the regulatory text. In the proposed rule, EPA 
inadvertently omitted the regulatory text for the term referencing the 
exposure monitoring threshold level of 0.01 mg/m\3\ 8-hour TWA. In 
addition, EPA is changing the term ``no dust air releases of the PMN 
substance'' to releases to air must be prevented ``unless exhaust from 
enclosed equipment is treated with combined capture and control 
technology that achieves a >=99.8% capture and control efficiency.'' 
EPA agrees with the commentor that releases to air must be prevented 
unless exhaust from enclosed equipment is treated with combined capture 
and control technology that achieves a >=99.8% capture and control 
efficiency.
    Additionally, EPA identified the need to revise the following 
proposed SNURs (listed by PMN Number and proposed 40 CFR citation):
    <bullet> For P-18-281 and P-21-077 (40 CFR 721.12147), EPA 
discovered that the respiratory protection requirement 721.62(a)(6) was 
erroneously omitted in the proposed rule. Therefore, EPA added the 
requirement 721.62(a)(6).
    <bullet> For P-20-73 (40 CFR 721.12148), EPA discovered that a 
requirement, no use in a consumer product, was erroneously omitted in 
the proposed rule that is included in the consent order for P-20-73. 
Therefore, EPA added no use in a consumer product (i.e., 721.80(o)).
    <bullet>For P-22-2 (40 CFR 721.12149), EPA discovered an ongoing 
use for this chemical substance and added the following requirement: 
when the chemical substance is handled as a liquid, a respirator with 
an APF 50 is allowed.
    <bullet> For P-23-30 (40 CFR 721.12160), EPA discovered that a 
hazard communication requirement that the substance is toxic to aquatic 
life was erroneously omitted in the proposed rule that is included in 
the consent order for P-23-30. Therefore, EPA added toxic to aquatic 
life to the required hazard communication (i.e., 727.72(g)(3)(iii)).
    <bullet> For P-24-71 through P-24-74 (40 CFR 721.12179-40 CFR 
721.12182), EPA discovered that a hazard communication requirement that 
the substances for P-24-71 through P-24-74 are toxic to aquatic life 
was erroneously omitted in the proposed rule that is included in the 
consent order for P-24-71 through P-24-74. Therefore, EPA added toxic 
to aquatic life to the required hazard communication (i.e., 
727.72(g)(3)(iii)).
    EPA is not finalizing the SNUR proposed at 40 CFR 721.12154 for P-
22-0126 because the Agency has received new information on this 
substance requiring further review. This proposed SNUR will be 
addressed in a separate action.
    EPA did not propose a SNUR for P-22-0187 at 40 CFR 721.12158 
because the Agency received new information on this substance requiring 
further review. The Agency will propose a SNUR in a separate action.

III. Chemical Substances Subject to these SNURs

A. What is the designated cutoff date for ongoing uses?

    EPA designates the date of publication of the proposed rule as the 
cutoff date for determining whether the new use is ongoing, i.e., 
November 3, 2025 (90 FR 49148 (FRL-12742-01-OCSPP)). This designation 
is explained in more detail in Unit II.B.

B. What information was provided for each chemical substance?

    In Unit III.C. of the proposed rule, EPA provided the following 
information for each chemical substance subject to these SNURs:
    <bullet> PMN number (the CFR citation assigned in the regulatory 
text section of this document).
    <bullet> Chemical name (generic name, if the specific name is 
claimed as CBI).
    <bullet> Chemical Abstracts Service Registry Number (CASRN) or 
Accession Number (if assigned, for confidential chemical identities).
    <bullet> Basis for the SNUR (e.g., effective date of and basis for 
the TSCA Order).
    <bullet> Potentially useful information.
    The regulatory text section of this document specifies the chemical 
substances and activities designated as significant new uses. Certain 
new uses, including production volume limits and other uses designated, 
may be claimed as CBI, as discussed in more detail in Unit II.C. of the 
proposed rule.
    In addition, as discussed in Unit III.B. of the proposed rule, 
these SNURs include PMN substances that are subject to orders issued 
under TSCA section 5(e)(1)(A), as required by the determinations made 
under TSCA section 5(a)(3)(B). Those TSCA Orders require protective 
measures to limit exposures or otherwise mitigate the potential 
unreasonable risk. As such, the SNURs identify as significant new uses 
any manufacturing, processing, use, distribution in commerce, or 
disposal that does not conform to the restrictions imposed by the 
underlying TSCA Orders, consistent with TSCA section 5(f)(4).

IV. Statutory and Executive Order Reviews

    Additional information about these statutes and Executive orders 
can be found at <a href="https://www.epa.gov/laws-regulations-and-executive-orders">https://www.epa.gov/laws-regulations-and-executive-orders</a>.

A. Executive Order 12866: Regulatory Planning and Review

    This action establishes SNURs for new chemical substances that were 
the subject of PMNs. The Office of Management and Budget (OMB) has 
exempted these types of actions from review under Executive Order 12866 
(58 FR 51735, October 4, 1993).

B. Executive Order 14192: Unleashing Prosperity Through Deregulation

    Executive Order 14192 (90 FR 9065, February 6, 2025) does not apply 
because a significant new use rule for a new chemical under TSCA 
section 5 is exempt from review under Executive Order 12866.

C. Paperwork Reduction Act (PRA)

    According to the PRA (44 U.S.C. 3501 et seq.), an agency may not 
conduct or sponsor, and a person is not required to respond to a 
collection of information that requires OMB approval under PRA, unless 
it has been approved by OMB and displays a currently valid OMB control 
number. The OMB control numbers for EPA's regulations in title 40 of 
the CFR, after appearing in the Federal Register, are listed in 40 CFR 
part 9, and included on the related collection instrument or form, if 
applicable.
    The information collection requirements related to SNURs have 
already been approved by OMB pursuant to PRA under OMB control

[[Page 54995]]

number 2070-0038 (EPA ICR No. 1188). This action does not impose any 
burden requiring additional OMB approval. If an entity were to submit a 
SNUN to the Agency, the annual burden is estimated to average between 
30 and 170 hours per submission. This burden estimate includes the time 
needed to review instructions, search existing data sources, gather and 
maintain the data needed, and complete, review, and submit the required 
SNUN.

D. Regulatory Flexibility Act (RFA)

    I certify that this action will not have a significant economic 
impact on a substantial number of small entities under the RFA (5 
U.S.C. 601 et seq.). The requirement to submit a SNUN applies to any 
person (including small or large entities) who intends to engage in any 
activity described in the final rule as a ``significant new use.'' 
Because these uses are ``new,'' based on all information currently 
available to EPA, EPA has concluded that no small or large entities 
presently engage in such activities.
    A SNUR requires that any person who intends to engage in such 
activity in the future must first notify EPA by submitting a SNUN. 
Although some small entities may decide to pursue a significant new use 
in the future, EPA cannot presently determine how many, if any, there 
may be. However, EPA's experience to date is that, in response to the 
promulgation of SNURs covering over 1,000 chemicals, the Agency 
receives only a small number of notices per year. For example, the 
number of SNUNs received was 7 in Federal fiscal year (FY) 2020, 9 in 
FY2021, 9 in FY2022, 23 in FY2023, and 7 in FY2024, and only a fraction 
of these submissions were from small businesses.
    In addition, the Agency currently offers relief to qualifying small 
businesses by reducing the SNUN submission fee from $37,000 to $6,480. 
This lower fee reduces the total reporting and recordkeeping cost of 
submitting a SNUN to about $14,500 per SNUN submission for qualifying 
small firms. Therefore, the potential economic impacts of complying 
with these proposed SNURs are not expected to be significant or 
adversely impact a substantial number of small entities. In a SNUR that 
was published in the Federal Register of June 2, 1997 (62 FR 29684 
(FRL-5597-1)), the Agency presented its general determination that 
SNURs are not expected to have a significant economic impact on a 
substantial number of small entities, which was provided to the Chief 
Counsel for Advocacy of the Small Business Administration.

E. Unfunded Mandates Reform Act (UMRA)

    This action does not contain an unfunded mandate of $100 million or 
more (in 1995 dollars) in any one year as described in UMRA, 2 U.S.C. 
1531-1538, and does not significantly or uniquely affect small 
governments. Based on EPA's experience with proposing and finalizing 
SNURs, State, local, and Tribal governments have not been impacted by 
SNURs, and EPA does not have any reasons to believe that any State, 
local, or Tribal government will be impacted by these SNURs. In 
addition, the estimated costs of this action to the private sector do 
not exceed $183 million or more in any one year (the 1995 dollars are 
adjusted to 2023 dollars for inflation using the GDP implicit price 
deflator). The estimated costs for this action are discussed in Unit 
I.D.

F. Executive Order 13132: Federalism

    This action will not have federalism implications as specified in 
Executive Order 13132 (64 FR 43255, August 10, 1999), because it is not 
expected to have a substantial direct effect on States, on the 
relationship between the national government and the States, or on the 
distribution of power and responsibilities among the various levels of 
government. Accordingly, the requirements of Executive Order 13132 do 
not apply to this action.

G. Executive Order 13175: Consultation and Coordination With Indian 
Tribal Governments

    This action will not have Tribal implications as specified in 
Executive Order 13175 (65 FR 67249, November 9, 2000), because it is 
not expected to have substantial direct effects on Indian Tribes, 
significantly or uniquely affect the communities of Indian Tribal 
governments and does not involve or impose any requirements that affect 
Indian Tribes. Accordingly, the requirements of Executive Order 13175 
do not apply to this action.

H. Executive Order 13045: Protection of Children From Environmental 
Health Risks and Safety Risks

    This action is not subject to Executive Order 13045 (62 FR 19885, 
April 23, 1997), because it does not concern an environmental health or 
safety risk. Since this action does not concern a human health risk, 
EPA's 2026 Policy on Children's Health also does not apply. Although 
the establishment of these SNURs do not address an existing children's 
environmental health concern because the chemical uses involved are not 
ongoing uses, SNURs require that persons notify EPA at least 90 days 
before commencing manufacture (defined by statute to include import) or 
processing of the identified chemical substances for an activity that 
is designated as a significant new use by the SNUR. This notification 
allows EPA to assess the intended uses to identify potential risks and 
take appropriate actions before the activities commence.

I. Executive Order 13211: Actions Concerning Regulations That 
Significantly Affect Energy Supply, Distribution, or Use

    This action is not a ``significant energy action'' as defined in 
Executive Order 13211 (66 FR 28355, May 22, 2001), because it is not 
likely to have a significant adverse effect on the supply, 
distribution, or use of energy.

J. National Technology Transfer and Advancement Act (NTTAA)

    This action does not involve any technical standards subject to 
NTTAA section 12(d) (15 U.S.C. 272 note).

K. Congressional Review Act (CRA)

    This action is subject to the CRA (5 U.S.C. 801 et seq.), and EPA 
will submit a rule report to each House of the Congress and to the 
Comptroller General of the United States. This action is not a ``major 
rule'' as defined by 5 U.S.C. 804(2).

List of Subjects in 40 CFR Part 721

    Environmental protection, Chemicals, Hazardous substances, 
Reporting and recordkeeping requirements.

    Dated: August 19, 2026.
Mary Elissa Reaves,
Director, Office of Pollution Prevention and Toxics.

    For the reasons stated in the preamble, 40 CFR chapter I is amended 
as follows:

PART 721--SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES

0
1. The authority citation for part 721 continues to read as follows:

    Authority: 15 U.S.C. 2604, 2607, and 2625(c).


0
2. Add Sec. Sec.  721.12147 through 721.12183 to subpart E to read as 
follows:
* * * * *
Sec.
721.12147 Cyclic sulfate (generic).
721.12148 2,5-Furandione, reaction products with alkylamine, 1-
octanol and

[[Page 54996]]

polyethylene glycol alkoxy-ether, acetates (salts) (generic).
721.12149 Metal oxide chloride (generic).
721.12150 Ethanol, 2-amino-, compds. with polyethylene glycol 
hydrogen sulfate C10-16-alkyl ether.
721.12151 Edge oxidized graphene.
721.12152 Propaneamine, 3-(alkyloxy)-, structural variants 
(generic).
721.12153 Propanenitrile, 3-(alkyloxy)-, structural variance 
(generic).
721.12154 [Reserved]
721.12155 Alkyl dialkylamine (generic).
721.12156 Tetraalkylammonium chloride (generic).
721.12157 1,3,5-Cycloheptatriene.
721.12158 [Reserved]
721.12159 Amines, polyalkylenepoly, (disubstitutedcarboxy) derivs., 
alkali metal salts (generic).
721.12160 Phenol, polyalkylcarbo bis-, polymer with 2-
carbomonocyclichaloheteromonocycle, 
bis[(alkenylcarbomonocyclic)alkyl] ether (generic).
721.12161 Siloxanes and silicones, di-alkyl, hydroxy-terminated, 
polymers with substituted alkane and substituted silane (generic).
721.12162 Alkyl acid, 2-hydroxy-, methyl substituted alkyl ester 
(generic).
721.12163 Oils, Pisum sativum, polymers with 1,6-diisocyanatohexane, 
1,5-diisocyanatopentane, glycerol and maltodextrin.
721.12164 Rosin, maleated, polymer with benzoic acid, glycerol, 
propylene glycol and 3a,4,7,7a-tetrahydro-1,3- isobenzofurandione.
721.12165 Glycine, reaction products with oxidized maltodextrin.
721.12166 Maltodextrin, 6-[3-(dimethyl-2-propen-1-ylammonio)propyl] 
ether, chloride.
721.12167 Dextran, 3-(dimethyl-2-propen-1-ylammonio)propyl ether, 
chloride.
721.12168 Maltodextrin, oxidized, reaction products with 
ethylenediamine.
721.12169 Maleic modified rosin polyol ester cyclic acid (generic).
721.12170 Phenol, polyalkylcarbomonocycle bis-, polymer with 2- 
carbomonocyclichaloheteromonocycle, 
bis[(alkenylcarbomonocyclic)alkyl] ether (generic).
721.12171 Alken-1-ol, 1-acetate (generic).
721.12172 1-Alkanethiol, 3-(trialkoxysilyl)- hydrolysis products 
with silica, oxidized (generic).
721.12173 Alkenoyl chloride, 3-methyl- (generic).
721.12174 Bismuth, 1,1',1'',1'''-(1,2-
ethanediyldinitrilo)tetrakis[2-propanol] 2-(2-ethoxyethoxy)ethanol 
neodecanoate polypropylene glycol complexes.
721.12175 Alkane, bis(chlorosilane) (generic).
721.12176 Mixed metal oxide (generic).
721.12177 Alkenoic acid, 3-methyl-, 1,1-dimethyl-2-propen-1-yl 
ester; alkenoic acid, 3-methyl-, 1,1-dimethyl-2-propen-1-yl ester 
(generic).
721.12178 Fluorophospholane, substituted, alkyl (generic).
721.12179 Sulfonyl carbamate of ethoxylated fatty alcohol (generic).
721.12180 Sulfonyl carbamate of ethoxylated alkyl alcohol (generic).
721.12181 Secondary alcohol ethoxylate of sulfonyl carbamate 
(generic).
721.12182 Secondary alcohol ethoxylate of sulfonyl carbamate 
(generic).
721.12183 Sulfonium, polyphenyl(substituted phenyl) 
alkylbenzenesulfonate (generic).
* * * * *


Sec.  721.12147  Cyclic sulfate (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as cyclic 
sulfate (PMNs P-18-281 and P-21-77; Accession No. 301816) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely reacted or cured or incorporated into an article as defined 
in Sec.  720.3(c).
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 1,000 or at least 50 when using 
less than the confidential annual production volume listed in the Order 
(measured on a year-to-year basis) of the substance at a use site and 
when receiving the substance at 1% or less in formulation, prior to the 
receipt of exposure monitoring results. Once exposure monitoring 
results are available, respirators must provide a NIOSH APF in 
accordance with Appendix 4 in the modified Order for P-18-281 (which 
lists required respiratory protection/action corresponding to different 
exposures), and exposure monitoring results must be equal to or less 
than 0.01 mg/m\3\ as an 8-hour time-weighted average. Persons who wish 
to conduct monitoring in accordance with Appendix 4 in the modified 
Order for P-18-0281 as an alternative to Sec.  721.63 respirator 
requirements may request to do so under Sec.  721.30.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin corrosion, serious eye damage, skin sensitization, 
genetic toxicity, carcinogenicity, and specific target organ toxicity. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and the Occupational Safety and Health 
Administration (OSHA) Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(f). It is a significant new use to use the 
substance other than for the confidential uses allowed by the Orders 
for P-18-281 and P-21-77. It is a significant new use to process the 
substance above 5% in formulation. It is a significant new use to have 
releases to air of the substance unless exhaust from enclosed equipment 
is treated with combined capture and control technology that achieves a 
>=99.8% capture and control efficiency.
    (iv) Disposal. It is a significant new use to dispose of the 
substance or waste streams containing the substance other than by using 
the confidential method(s) described in the submission for P-21-77, or 
by landfill, deep well injection, or using a hazardous waste 
incinerator with >=99.999% efficiency.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4) where N=152.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12148  2,5-Furandione, reaction products with alkylamine, 1-
octanol and polyethylene glycol alkoxy-ether, acetates (salts) 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 2,5-
furandione, reaction products with alkylamine, 1-octanol and 
polyethylene glycol alkoxy-ether, acetates (salts) (PMN P-20-73) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When

[[Page 54997]]

determining which persons are reasonably likely to be exposed as 
required for Sec.  721.63(a)(1), engineering control measures (e.g., 
enclosure or confinement of the operation, general and local 
ventilation) or administrative control measures (e.g., workplace 
policies and procedures) shall be considered and implemented to prevent 
exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin corrosion, serious eye damage, respiratory 
sensitization, skin sensitization, reproductive toxicity, and specific 
target organ toxicity. Alternative hazard and warning statements that 
meet the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=160.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12149  Metal oxide chloride (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as metal 
oxide chloride (PMN P-22-2; Accession No. 303436) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely reacted or destroyed.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 1,000 when the chemical substance 
is handled as a solid, and an APF of at least 50 when the chemical 
substance is handled as a liquid.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: skin corrosion, serious eye 
damage, carcinogenicity, specific target organ toxicity, and 
reproductive toxicity. Alternative hazard and warning statements that 
meet the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k) and (t). It is a significant new use to 
manufacture or process the substance other than in a sealed, inert 
atmosphere environment of a sealed drybox wherever feasible. For 
activities performed outside of the drybox that may generate dust or 
any exhaust to air, all streams must be treated with caustic water 
control technology with a minimum of 90% destruction efficiency.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12150   Ethanol, 2-amino-, compds. with polyethylene glycol 
hydrogen sulfate C10-16-alkyl ether.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as ethanol, 2-amino-, 
compds. with polyethylene glycol hydrogen sulfate C10-16-alkyl ether 
(PMN P-22-53; CASRN 157627-92-4) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), and (3), and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin irritation, eye irritation, skin sensitization, 
reproductive toxicity, and specific target organ toxicity. Alternative 
hazard and warning statements that meet the criteria of the Globally 
Harmonized System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=14.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12151  Edge oxidized graphene (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as edge 
oxidized carbon matrix (PMN P-22-114) is subject to reporting under 
this section for the significant new uses described in paragraph (a)(2) 
of this section. The requirements of this section do not apply to 
quantities of the substance when entrained in a cured coating or when 
incorporated into an article.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(4) through (6) and (c). When determining which persons are

[[Page 54998]]

reasonably likely to be exposed as required for Sec.  721.63(a)(4), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible. For purposes of 
Sec.  721.63(a)(5), respirators must provide a National Institute for 
Occupational Safety and Health (NIOSH) assigned protection factor (APF) 
of at least 10,000.
    (A) As an alternative to the respirator requirements in paragraph 
(a)(2)(i) of this section, a manufacturer or processor may choose to 
follow the new chemical exposure limit (NCEL) provision listed in the 
TSCA section 5(e) Order for this substance. The NCEL is 0.00733 mg/m\3\ 
as an 8-hour time weighted average. Persons who wish to pursue NCELs as 
an alternative to Sec.  721.63 respirator requirements may request to 
do so under Sec.  721.30. Persons whose Sec.  721.30 requests to use 
the NCELs approach are approved by EPA will be required to follow NCELs 
provisions comparable to those contained in the corresponding TSCA 
section 5(e) Order.
    (B) [Reserved]
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: specific 
target organ toxicity. Alternative hazard and warning statements that 
meet the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k) and (t).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (d), (f) through (i), and (k) are applicable to 
manufacturers, importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12152  Propaneamine, 3-(alkyloxy)-, structural variants 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
propaneamine, 3-(alkyloxy)-, structural variants (PMN P-22-123) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin corrosion, serious eye damage, reproductive toxicity, 
and specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=6.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12153  Propanenitrile, 3-(alkyloxy)-, structural variance 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
propanenitrile, 3-(alkyloxy)-, structural variance (PMN P-22-124) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin irritation, eye irritation, skin sensitization, genetic 
toxicity, reproductive toxicity, specific target organ toxicity, and 
carcinogenicity. Alternative hazard and warning statements that meet 
the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(h). It is a significant new use to 
manufacture the substance with the residual confidential feedstock 
listed in the Order present at greater than 1% by weight.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=45.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12154  [Reserved]


Sec.  721.12155  Alkyl dialkylamine (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as alkyl 
dialkylamine (PMN P-22-137; Accession No. 302911) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in

[[Page 54999]]

Sec.  721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin corrosion, serious eye damage, reproductive toxicity, 
and specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(t). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance. It is a significant new use to 
manufacture, process, or use the substance at any facility not equipped 
with pollution controls with a destruction efficiency of 99.98% or 
greater. It is a significant new use to use the substance other than as 
a chemical intermediate for a quaternary ammonium salt.
    (iv) Disposal. Requirements as specified in Sec.  721.85 (a)(1) and 
(3), (b)(1) and (3), and (c)(1), and (3).
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12156  Tetraalkylammonium chloride (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
tetraalkylammonium chloride (PMN P-22-138; Accession No. 302922) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin irritation, eye irritation, and specific target organ 
toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. It is a 
significant new use to manufacture, process, or use the substance in 
any manner that results in inhalation exposure to the substance. It is 
a significant new use to manufacture, process, or use the substance at 
any facility not equipped with pollution controls with a destruction 
efficiency of 99.98% or greater. It is a significant new use to use the 
substance other than as an intermediate for making hydroxide salt.
    (iv) Disposal. Requirements as specified in Sec.  721.85(a)(1) and 
(3), (b)(1) and (3), (c)(1) and (3).
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12157  1,3,5-Cycloheptatriene.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as 1,3,5-
cycloheptatriene (PMN P-22-185; CASRN 544-25-2) is subject to reporting 
under this section for the significant new uses described in paragraph 
(a)(2) of this section. The requirements of this section do not apply 
to quantities of the substance after they have been completely reacted 
or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, eye irritation, skin irritation, skin sensitization, and 
specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(g). It is a significant new use to 
manufacture, process, or use the substance in any manner unless using 
engineering control measures that ensure that loading and unloading of 
transport containers does not result in inhalation exposures to the 
substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12158   [Reserved]


Sec.  721.12159  Amines, polyalkylenepoly, (disubstitutedcarboxy) 
derivs., alkali metal salts (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified

[[Page 55000]]

generically as amines, polyalkylenepoly, (disubstitutedcarboxy) 
derivs., alkali metal salts (PMN P-23-15; Accession No. 303469) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin corrosion, serious eye damage, skin sensitization, 
reproductive toxicity, and specific target organ toxicity. Alternative 
hazard and warning statements that meet the criteria of the Globally 
Harmonized System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=23.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12160  Phenol, polyalkylcarbo bis-, polymer with 2-
carbomonocyclichaloheteromonocycle, bis[(alkenylcarbomonocyclic)alkyl] 
ether (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as phenol, 
polyalkylcarbo bis-, polymer with 2-carbomonocyclichaloheteromonocycle, 
bis[(alkenylcarbomonocyclic)alkyl] ether (PMN P-23-30) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been dried to 
the extent that no release of the substance can be detected.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin irritation, eye irritation, respiratory sensitization, 
skin sensitization, genetic toxicity, carcinogenicity, reproductive 
toxicity, and specific target organ toxicity. Alternative hazard and 
warning statements that meet the criteria of the Globally Harmonized 
System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k), (w)(1), (2), (4), and (x)(1), (2), and 
(4). It is a significant new use to process or use the substance in any 
manner that results in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12161  Siloxanes and silicones, di-alkyl, hydroxy-terminated, 
polymers with substituted alkane and substituted silane (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
siloxanes and silicones, di-alkyl, hydroxy-terminated, polymers with 
substituted alkane and substituted silane (PMN P-23-46) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: acute 
toxicity, skin corrosion, serious eye damage, reproductive toxicity, 
and specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o), (v)(1), (2), and (4), (w)(1), (2), and 
(4), and (x)(1), (2), and (4).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12162  Alkyl acid, 2[hyphen]hydroxy[hyphen], methyl 
substituted alkyl ester (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified

[[Page 55001]]

generically as alkyl acid, 2[hyphen]hydroxy[hyphen], methyl substituted 
alkyl ester (PMN P-23-65) is subject to reporting under this section 
for the significant new uses described in paragraph (a)(2) of this 
section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), and (3) through (6), and (c). When determining which 
persons are reasonably likely to be exposed as required for Sec.  
721.63(a)(1) and (4), engineering control measures (e.g., enclosure or 
confinement of the operation, general and local ventilation) or 
administrative control measures (e.g., workplace policies and 
procedures) shall be considered and implemented to prevent exposure, 
where feasible. For purposes of Sec.  721.63(a)(5), respirators must 
provide a National Institute for Occupational Safety and Health (NIOSH) 
assigned protection factor (APF) of at least 1,000.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: skin 
irritation, serious eye damage, reproductive toxicity, specific target 
organ toxicity, and carcinogenicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(k).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=220.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i), and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12163  Oils, Pisum sativum, polymers with 1,6-
diisocyanatohexane, 1,5-diisocyanatopentane, glycerol and maltodextrin.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as oils, pisum 
sativum, polymers with 1,6-diisocyanatohexane, 1,5-diisocyanatopentane, 
glycerol and maltodextrin (PMN P-23-69; CASRN 3063505-38-1) is subject 
to reporting under this section for the significant new uses described 
in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: specific target organ toxicity 
(lung effect if the product becomes airborne). Alternative hazard and 
warning statements that meet the criteria of the Globally Harmonized 
System and OSHA Hazard Communication Standard may be used.
    (ii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(y)(1) and (2). It is a significant new use 
to manufacture or process the substance in a manner that generates a 
vapor, mist, aerosol, or dust. It is a significant new use to process 
the substance for use in a consumer product that can be spray applied.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (c) and (f) through (i) are applicable to 
manufacturers, importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12164  Rosin, maleated, polymer with benzoic acid, glycerol, 
propylene glycol and 3a,4,7,7a-tetrahydro-1,3- isobenzofurandione.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as rosin, maleated, 
polymer with benzoic acid, glycerol, propylene glycol and 3a,4,7,7a-
tetrahydro-1,3- isobenzofurandione (PMN P-23-79; CASRN 2766660-60-8) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: eye 
irritation, skin sensitization, and respiratory sensitization. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12165  Glycine, reaction products with oxidized maltodextrin.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as glycine, reaction 
products with oxidized maltodextrin (PMN P-23-88; CASRN 2837980-16-0) 
is subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3), and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.

[[Page 55002]]

    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: carcinogenicity and specific 
target organ toxicity. Alternative hazard and warning statements that 
meet the criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12166  Maltodextrin, 6-[3-(dimethyl-2-propen-1-
ylammonio)propyl] ether, chloride.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as maltodextrin, 6-[3-
(dimethyl-2-propen-1-ylammonio)propyl] ether, chloride (PMN P-23-89; 
CASRN 2839190-60-0) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance after they have been completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: respiratory 
sensitization, skin sensitization, genetic toxicity, carcinogenicity, 
and specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=14.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12167  Dextran, 3-(dimethyl-2-propen-1-ylammonio)propyl 
ether, chloride.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as dextran, 3-
(dimethyl-2-propen-1-ylammonio)propyl ether, chloride (PMN P-23-90; 
CASRN 2878360-71-3) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: respiratory 
sensitization, skin sensitization, genetic toxicity, carcinogenicity, 
and specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=2.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12168  Maltodextrin, oxidized, reaction products with 
ethylenediamine.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as maltodextrin, 
oxidized, reaction products with ethylenediamine (PMN P-23-91; CASRN 
2824987-68-8) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance after they have been completely reacted or cured.
    (2) The significant new uses are:
    (i) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: 
carcinogenicity and specific target organ toxicity. Alternative hazard 
and warning statements that meet the criteria of the Globally 
Harmonized System and OSHA Hazard Communication Standard may be used.
    (ii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (iii) Release to water. Requirements as specified in Sec.  
721.90(a)(4), (b)(4), and (c)(4), where N=2.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (c), (f) through (i), and (k) are applicable to 
manufacturers, importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The

[[Page 55003]]

provisions of Sec.  721.185 apply to this section.


Sec.  721.12169  Maleic modified rosin polyol ester cyclic acid 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as maleic 
modified rosin polyol ester cyclic acid (PMN P-23-92) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) through (6), and (c). When determining which 
persons are reasonably likely to be exposed as required for Sec.  
721.63(a)(1) and (4), engineering control measures (e.g., enclosure or 
confinement of the operation, general and local ventilation) or 
administrative control measures (e.g., workplace policies and 
procedures) shall be considered and implemented to prevent exposure, 
where feasible. For purposes of Sec.  721.63(a)(5), respirators must 
provide a National Institute for Occupational Safety and Health (NIOSH) 
assigned protection factor (APF) of at least 50, or 1,000 when the 
substance is spray applied.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: eye 
irritation, skin sensitization, and respiratory sensitization. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12170  Phenol, polyalkylcarbomonocycle bis-, polymer with 2-
carbomonocyclichaloheteromonocycle, bis[(alkenylcarbomonocyclic)alkyl] 
ether (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as phenol, 
polyalkylcarbomonocycle bis-, polymer with 2-
carbomonocyclichaloheteromonocycle, bis[(alkenylcarbomonocyclic)alkyl] 
ether (PMN P-23-123) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance upon being dried to the extent that no release of the 
substance can be detected.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and(3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity, skin 
irritation, eye irritation, skin sensitization, genetic toxicity, 
reproductive toxicity, carcinogenicity, and specific target organ 
toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o), (w)(1), (2), (4), (x)(1) and (2) and 
(4). It is a significant new use to process or use the substance in any 
manner that results in inhalation exposure to the substance.
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12171  Alken-1-ol, 1-acetate (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as alken-
1-ol, 1-acetate (PMN P-23-135; Accession No. 302591) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 10.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: skin 
irritation, eye irritation, skin sensitization, and specific target 
organ toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o).
    (iv) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) and (k) are applicable to manufacturers, 
importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12172  1-Alkanethiol, 3-(trialkoxysilyl)- hydrolysis products 
with silica, oxidized (generic).

    (a) Chemical substance and significant new uses subject to

[[Page 55004]]

reporting.(1) The chemical substance identified generically as 1-
alkanethiol, 3-(trialkoxysilyl)- hydrolysis products with silica, 
oxidized (PMN P-23-152; Accession No. 302819) is subject to reporting 
under this section for the significant new uses described in paragraph 
(a)(2) of this section.
    (2) The significant new uses are:
    (i) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: specific target organ toxicity. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (ii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (c) and (f) through (i) are applicable to 
manufacturers, importers, and processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12173  Alkenoyl chloride, 3-methyl- (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
alkenoyl chloride, 3-methyl- (PMN P-23-160; Accession No. 302660) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, 
skin sensitization, respiratory sensitization, serious eye damage, and 
specific target organ toxicity. Alternative hazard and warning 
statements that meet the criteria of the Globally Harmonized System and 
OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer use. Requirements as 
specified in Sec.  721.80(o).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12174  Bismuth, 1,1',1'',1'''-(1,2-
ethanediyldinitrilo)tetrakis[2-propanol] 2-(2-ethoxyethoxy)ethanol 
neodecanoate polypropylene glycol complexes.

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified as bismuth, 
1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis[2-propanol] 2-(2-
ethoxyethoxy)ethanol neodecanoate polypropylene glycol complexes (PMN 
P-23-164; CASRN 2374117-53-8) is subject to reporting under this 
section for the significant new uses described in paragraph (a)(2) of 
this section. The requirements of this section do not apply to 
quantities of the substance after they have been completely reacted or 
cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 10.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1), and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: skin irritation, eye 
irritation, and specific target organ toxicity. Alternative hazard and 
warning statements that meet the criteria of the Globally Harmonized 
System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o). It is a significant new use to use the 
substance unless the concentration of the substance does not exceed the 
confidential percentage by weight in the final (end use) formulation 
listed in the Order.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12175  Alkane, bis(chlorosilane) (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as alkane, 
bis(chlorosilane) (PMN P-23-169; Accession No. 303447) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, 
serious eye damage, reproductive toxicity, and specific target organ 
toxicity. Alternative hazard and warning statements that meet the

[[Page 55005]]

criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(g). It is a significant new use to 
manufacture, process, or use the substance in any manner that results 
in inhalation exposure to the substance.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12176  Mixed metal oxide (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as mixed 
metal oxide (PMN P-23-174; Accession No. 302831) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been 
incorporated into an article as defined at 40 CFR 720.3(c) or after 
they have been embedded in or cured in a matrix.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 1,000 before conducting the 
exposure monitoring described in the Order and then an APF based on the 
results of exposure monitoring as described in the Order. It is a 
significant new use to manufacture the chemical substance without the 
monitoring program required in the Order.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: 
carcinogenicity, genetic toxicity, skin sensitization, respiratory 
sensitization, and specific target organ toxicity. Alternative hazard 
and warning statements that meet the criteria of the Globally 
Harmonized System and OSHA Hazard Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(f) and (k). It is a significant new use to 
process the substance other than with the confidential substance 
described in the Order at a composition less than the confidential 
percentage listed in the Order. It is a significant new use to process 
the substance other than as described in the Order unless using 
process/engineering controls that achieve exposures no greater than 
those achieved using the controls described in the Order.
    (iv) Disposal. It is a significant new use to dispose of the 
substance, or waste streams containing the substance, domestically 
other than by RCRA Subtitle D Landfill requirements or RCRA Subtitle C 
Hazardous Waste Landfill requirements for wastes from equipment 
cleaning and deionization of defective cells generated during 
processing and use, or by RCRA Subtitle C Hazardous Waste Landfill 
requirements for all other wastes.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12177  Alkenoic acid, 3-methyl-, 1,1-dimethyl-2-propen-1-yl 
ester; alkenoic acid, 3-methyl-, 1,1-dimethyl-2-propen-1-yl ester 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substances identified generically as 
alkenoic acid, 3-methyl-, 1,1-dimethyl-2-propen-1-yl ester; alkenoic 
acid, 3-methyl-, 1,1-dimethyl-2-propen-1-yl ester (PMN P-23-188) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (3) through (6), and (c). When determining which persons 
are reasonably likely to be exposed as required for Sec.  721.63(a)(1) 
and (4), engineering control measures (e.g., enclosure or confinement 
of the operation, general and local ventilation) or administrative 
control measures (e.g., workplace policies and procedures) shall be 
considered and implemented to prevent exposure, where feasible. For 
purposes of Sec.  721.63(a)(5), respirators must provide a National 
Institute for Occupational Safety and Health (NIOSH) assigned 
protection factor (APF) of at least 50.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), these substances may cause: acute 
toxicity, reproductive toxicity, and specific target organ toxicity. 
Alternative hazard and warning statements that meet the criteria of the 
Globally Harmonized System and OSHA Hazard Communication Standard may 
be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(a) through (c), and (o).
    (iv) Disposal. Requirements as specified in Sec.  721.85(a)(1), 
(b)(1), and (c)(1).
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of these substances.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12178  Fluorophospholane, substituted, alkyl (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
fluorophospholane, substituted, alkyl (PMN P-23-190) is subject to 
reporting under this section for the significant new uses described in 
paragraph (a)(2) of this section. The requirements of this section do 
not apply to quantities of the substance after they have been entrained 
in an article as defined at 40 CFR 720.3(c).
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in

[[Page 55006]]

Sec.  721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), and (g)(1) and (5). For purposes of Sec.  
721.72(g)(1), this substance may cause: acute toxicity, skin corrosion, 
serious eye damage, reproductive toxicity, and specific target organ 
toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(a) through (c), and (o).
    (iv) Disposal. Requirements as specified in Sec.  721.85(a)(1), 
(b)(1), and (c)(1).
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12179  Sulfonyl carbamate of ethoxylated fatty alcohol 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
sulfonyl carbamate of ethoxylated fatty alcohol (PMN P-24-71) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: skin 
irritation, eye irritation, reproductive toxicity, and specific target 
organ toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o) and (y)(1) and (2). It is a significant 
new use to manufacture or process the substance in a manner that 
generates a vapor, mist, aerosol, or dust.
    (iv) Disposal. It is a significant new use to dispose of the 
substance other than by hazardous waste incineration in compliance with 
the Resource Conservation and Recovery Act (RCRA).
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12180  Sulfonyl carbamate of ethoxylated alkyl alcohol 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
sulfonyl carbamate of ethoxylated alkyl alcohol (PMN P-24-72) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after they have 
been completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: skin 
irritation, eye irritation, reproductive toxicity, and specific target 
organ toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o) and (y)(1) and (2). It is a significant 
new use to manufacture or process the substance in a manner that 
generates a vapor, mist, aerosol, or dust.
    (iv) Disposal. It is a significant new use to dispose of the 
substance other than by hazardous waste incineration in compliance with 
RCRA.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12181  Secondary alcohol ethoxylate of sulfonyl carbamate 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
secondary alcohol ethoxylate of sulfonyl carbamate (PMN P-24-73 is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after it has been 
completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general

[[Page 55007]]

and local ventilation) or administrative control measures (e.g., 
workplace policies and procedures) shall be considered and implemented 
to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g)(1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: skin 
irritation, eye irritation, reproductive toxicity, and specific target 
organ toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o) and (y)(1) and (2). It is a significant 
new use to manufacture or process the substance in a manner that 
generates a vapor, mist, aerosol, or dust.
    (iv) Disposal. It is a significant new use to dispose of this 
substance other than by hazardous waste incineration in compliance with 
RCRA.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12182  Secondary alcohol ethoxylate of sulfonyl carbamate 
(generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
secondary alcohol ethoxylate of sulfonyl carbamate (PMN P-24-74) is 
subject to reporting under this section for the significant new uses 
described in paragraph (a)(2) of this section. The requirements of this 
section do not apply to quantities of the substance after it has been 
completely reacted or cured.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1) and (3) and (c). When determining which persons are 
reasonably likely to be exposed as required for Sec.  721.63(a)(1), 
engineering control measures (e.g., enclosure or confinement of the 
operation, general and local ventilation) or administrative control 
measures (e.g., workplace policies and procedures) shall be considered 
and implemented to prevent exposure, where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (d), (f), (g) (1), (g)(3)(iii), and (g)(5). For 
purposes of Sec.  721.72(g)(1), this substance may cause: skin 
irritation, eye irritation, reproductive toxicity, and specific target 
organ toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(o) and (y)(1) and (2). It is a significant 
new use to manufacture or process the substance in a manner that 
generates a vapor, mist, aerosol, or dust.
    (iv) Disposal. It is a significant new use to dispose of this 
substance other than by hazardous waste incineration in compliance with 
RCRA.
    (v) Release to water. Requirements as specified in Sec.  
721.90(a)(1), (b)(1), and (c)(1).
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (k) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.


Sec.  721.12183  Sulfonium, polyphenyl (substituted phenyl) 
alkylbenzenesulfonate (generic).

    (a) Chemical substance and significant new uses subject to 
reporting. (1) The chemical substance identified generically as 
sulfonium, polyphenyl (substituted phenyl) alkylbenzenesulfonate (PMN 
P-24-122) is subject to reporting under this section for the 
significant new uses described in paragraph (a)(2) of this section. The 
requirements of this section do not apply to quantities of the 
substance after they have been completely reacted or adhered onto a 
semiconductor wafer surface or similar manufactured article used in the 
production of semiconductor technologies.
    (2) The significant new uses are:
    (i) Protection in the workplace. Requirements as specified in Sec.  
721.63(a)(1), (a)(2)(i) and (iii), (a)(3), and (c). When determining 
which persons are reasonably likely to be exposed as required for Sec.  
721.63(a)(1), engineering control measures (e.g., enclosure or 
confinement of the operation, general and local ventilation) or 
administrative control measures (e.g., workplace policies and 
procedures) shall be considered and implemented to prevent exposure, 
where feasible.
    (ii) Hazard communication. Requirements as specified in Sec.  
721.72(a) through (f), (g)(1), (g)(2)(i) through (iii), (g)(2)(v), 
(g)(3)(i) and (ii), and (g)(5). For purposes of Sec.  721.72(e), the 
concentration is set at 1.0%. For purposes of Sec.  721.72(g)(1), this 
substance may cause: acute toxicity, skin irritation, serious eye 
damage, skin sensitization, genetic toxicity, and specific target organ 
toxicity. Alternative hazard and warning statements that meet the 
criteria of the Globally Harmonized System and OSHA Hazard 
Communication Standard may be used.
    (iii) Industrial, commercial, and consumer activities. Requirements 
as specified in Sec.  721.80(f) and (k). It is a significant new use to 
exceed an annual importation volume of 6 kilograms for any use. It is a 
significant new use to import the substance other than in solution, 
unless in sealed containers weighing 5 kilograms or less. It is a 
significant new use to process the substance in any way that generates 
dust, mist, or aerosol in a non-enclosed process. It is a significant 
new use to manufacture the substance longer than 18 months.
    (b) Specific requirements. The provisions of subpart A of this part 
apply to this section except as modified by this paragraph (b).
    (1) Recordkeeping. Recordkeeping requirements as specified in Sec.  
721.125(a) through (i) are applicable to manufacturers, importers, and 
processors of this substance.
    (2) Limitation or revocation of certain notification requirements. 
The provisions of Sec.  721.185 apply to this section.

[FR Doc. 2026-17400 Filed 8-25-26; 8:45 am]
BILLING CODE 6560-50-P


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