Notice2026-17301
Glyphosate Open Literature Search To Inform Human Health Risk Assessment Notice of Availability
Primary source
Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.
Published
August 25, 2026
Issuing agencies
Environmental Protection Agency
Abstract
This notice announces the availability of the Environmental Protection Agency's (EPA or the Agency) open literature search in support of the ongoing registration review of glyphosate. This open literature search is intended to inform the hazard assessment for the upcoming updated glyphosate human health risk assessment, currently scheduled to be completed in late 2026. EPA is soliciting comments on the completeness of the Agency's open literature search results, and this notice opens a comment period on the open literature search.
Full Text
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<title>Federal Register, Volume 91 Issue 163 (Tuesday, August 25, 2026)</title>
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[Federal Register Volume 91, Number 163 (Tuesday, August 25, 2026)]
[Notices]
[Pages 54870-54871]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-17301]
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ENVIRONMENTAL PROTECTION AGENCY
[EPA-HQ-OPP-2009-0361; FRL-13597-01-OCSPP]
Glyphosate Open Literature Search To Inform Human Health Risk
Assessment Notice of Availability
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice.
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SUMMARY: This notice announces the availability of the Environmental
Protection Agency's (EPA or the Agency) open literature search in
support of the ongoing registration review of glyphosate. This open
literature search is intended to inform the hazard assessment for the
upcoming updated glyphosate human health risk assessment, currently
scheduled to be completed in late 2026. EPA is soliciting comments on
the completeness of the Agency's open literature search results, and
this notice opens a comment period on the open literature search.
DATES: Comments must be received on or before September 24, 2026.
ADDRESSES: Submit your comments, identified by docket identification
(ID) number EPA-HQ-OPP-2009-0361, through <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
Follow the online instructions for submitting comments. Do not submit
electronically any information you consider to be Confidential Business
Information (CBI) or other information whose disclosure is restricted
by statute. Additional instructions on commenting or visiting the
docket, along with more information about dockets generally, is
available at <a href="https://www.epa.gov/dockets">https://www.epa.gov/dockets</a>.
FOR FURTHER INFORMATION CONTACT: Cathryn Britton, Risk Management and
Implementation Branch 5, Pesticide Re-evaluation Division, Office of
Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania
Ave. NW, Washington, DC 20460-0001; telephone number: (202) 566-2339;
email address: <a href="/cdn-cgi/l/email-protection#1f7873666f77706c7e6b7a6d7a786d7a69767a685f7a6f7e31787069"><span class="__cf_email__" data-cfemail="f592998c859d9a869481908790928790839c9082b5908594db929a83">[email protected]</span></a>.
SUPPLEMENTARY INFORMATION:
I. General Information
A. Does this action apply to me?
This notice is directed to the public in general and may be of
interest to a wide range of stakeholders including environmental, human
health, farm workers, and agricultural advocates; the chemical
industry; pesticide users; and members of the public interested in the
sale, distribution, or use of pesticides. Since others may also be
interested, the Agency has not attempted to describe all the specific
entities that may be affected by this action.
B. What should I consider as I prepare my comments for EPA?
1. Submitting CBI
Do not submit CBI to EPA through <a href="https://www.regulations.gov">https://www.regulations.gov</a> or
email. If you wish to include CBI in your comment, please follow the
applicable instructions at <a href="https://www.epa.gov/dockets/commenting-epa-dockets#rules">https://www.epa.gov/dockets/commenting-epa-dockets#rules</a> and clearly mark the information that you claim to be
CBI. Information so marked will not be disclosed except in accordance
with procedures set forth in 40 CFR parts 2 and 703, as applicable.
2. Tips for Preparing Your Comments
When preparing and submitting your comments, see the commenting
tips at <a href="https://www.epa.gov/dockets/commenting-epa-dockets">https://www.epa.gov/dockets/commenting-epa-dockets</a>.
II. What action is the Agency taking?
The EPA's Office of Pesticide Programs (OPP) is currently
reevaluating glyphosate as part of registration review, which is
required by law every 15 years to ensure that pesticide products on the
market continue to meet the statutory standard for registration as
science evolves and new information becomes available. In addition to
guideline studies, required under 40 CFR part 158, and non-guideline
studies that are submitted to the EPA to support pesticide
registration, EPA searches for relevant studies published in peer-
reviewed scientific journals in the open literature. In the case of
glyphosate, there are a large number of independent studies available
in the open literature. Since the initiation of Registration Review,
EPA has performed multiple searches of open literature to identify,
screen, and evaluate potentially relevant studies using systematic
review approaches consistent with Executive Order 14303, Restoring Gold
Standard Science and Gold Standard Science (90 FR 22601; May 23, 2025)
objectives. In addition, EPA has received additional studies to
consider during public comment periods in the Registration Review
[[Page 54871]]
process. To supplement the previous human health open literature
searches, a new systematic open literature search was performed to
identify potentially relevant studies published more recently to inform
human health risk assessment. EPA's open literature search document
summarizes prior search efforts, details the search strategy, including
search terms, databases, and inclusion/exclusion criteria, and provides
an explanation of the multistep screening and evaluation process used
to determine study quality and relevance for inclusion in human health
risk assessment. Studies identified across all search efforts,
including those submitted through public comment, are listed in an
accompanying spreadsheet.
The objective of this public comment period is to solicit public
input to identify and submit any relevant, peer-reviewed studies that
are not included in this list of studies for consideration as part of
the upcoming updated human health risk assessment, which is targeted
for completion in late 2026 and subsequent release for public comment.
For the Agency to consider any submitted data or studies, there must be
open access to the article or study report and its supporting data.
When providing input to EPA, commenters should include the full
citation reference to the article that includes the study author(s),
date of publication, journal title, and the article title.
(Authority: 7 U.S.C. 136 et seq.)
Dated: August 20, 2026.
Jean Anne Overstreet,
Director, Pesticide Re-Evaluation Division, Office of Pesticide
Programs.
[FR Doc. 2026-17301 Filed 8-24-26; 8:45 am]
BILLING CODE 6560-50-P
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