Notice2026-03337

Prospective Grant of an Exclusive Patent License: In Vivo Manufactured Anti-CD19 Chimeric Antigen Receptor (CAR) Products for the Treatment or Prevention of B Cell Mediated Autoimmune Diseases

Primary source

Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.

Published
February 20, 2026

Issuing agencies

Health and Human Services DepartmentNational Institutes of Health

Abstract

The Department of Health and Human Services, National Institutes of Health published a Notice in the Federal Register on August 5, 2025. That notice requires a correction in the SUPPLEMENTARY INFORMATION section.

Full Text

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<title>Federal Register, Volume 91 Issue 34 (Friday, February 20, 2026)</title>
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[Federal Register Volume 91, Number 34 (Friday, February 20, 2026)]
[Notices]
[Pages 8261-8262]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2026-03337]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of an Exclusive Patent License: In Vivo 
Manufactured Anti-CD19 Chimeric Antigen Receptor (CAR) Products for the 
Treatment or Prevention of B Cell Mediated Autoimmune Diseases

AGENCY: National Institutes of Health, HHS.

ACTION: Notice; correction.

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SUMMARY: The Department of Health and Human Services, National 
Institutes of Health published a Notice in the Federal Register on 
August 5, 2025. That notice requires a correction in the SUPPLEMENTARY 
INFORMATION section.

DATES: Only written comments and/or applications for a license which 
are received by the National Cancer Institute's Technology Transfer 
Center on or before March 9, 2026 will be considered.

ADDRESSES: Inquiries and comments relating to the contemplated 
Exclusive Patent License should be directed to: Andrew Burke, Ph.D., 
Senior Technology Transfer Manager, NCI Technology Transfer Center, 
Telephone: (240)-276-5484; Email: <a href="/cdn-cgi/l/email-protection#73121d170a5d1106011816331d1a1b5d141c05"><span class="__cf_email__" data-cfemail="3859565c41165a4d4a535d78565150165f574e">[email&#160;protected]</span></a>.

SUPPLEMENTARY INFORMATION:

Correction

    In the Federal Register of February 13, 2026, in FR Doc. 2026-
02907, on page 6864, as found within the SUPPLEMENTARY INFORMATION 
section. Currently reads:
    ``The development, production, and commercialization of an anti-
CD19 targeting chimeric antigen receptor (CAR)-based immunotherapy 
using a:

1. non-viral synthetic nanoparticle-based system, or
2. viral system (excluding lentiviral)

that encapsulates mRNA or DNA encoding a CAR having the complementary 
determining region (CDR) sequences of the anti-CD19 scFv known as Hu19, 
for the treatment or prevention of autoimmune diseases. And is 
corrected to read:
    ``The development, production, and commercialization of an anti-
CD19 targeting chimeric antigen receptor (CAR)-based immunotherapy 
using a:

3. non-viral synthetic nanoparticle-based system, or
4. viral system

that encapsulates mRNA or DNA encoding a CAR having the complementary 
determining region

[[Page 8262]]

(CDR) sequences of the anti-CD19 scFv known as Hu19, for the treatment 
or prevention of autoimmune diseases.

Alycia Booth,
NIH Federal Register Certifying Official, National Institutes of 
Health.
[FR Doc. 2026-03337 Filed 2-19-26; 8:45 am]
BILLING CODE 4140-01-P


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Indexed from Federal Register on February 20, 2026.

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