Notice2025-21673

Certain New Chemicals; Receipt and Status Information for August-September 2025

Primary source

Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.

Published
December 1, 2025

Issuing agencies

Environmental Protection Agency

Abstract

This document announces the Agency's receipt of new chemical submissions under the Toxic Substances Control Act (TSCA), including information about the receipt of a Premanufacture Notice (PMN), Significant New Use Notice (SNUN), Microbial Commercial Activity Notice (MCAN), and an amendment to a previously submitted notice; test information; a biotechnology exemption application; an application for a test marketing exemption (TME); and a notice of commencement of manufacture (defined by statute to include import) (NOC) for a new chemical substance. This document also provides a periodic status report on the new chemical substances that are currently under EPA review or have recently concluded review. EPA is hereby providing notice of receipt of this information, as required by TSCA, and an opportunity to comment. This document covers the period from 9/1/2025 to 9/30/2025.

Full Text

<html>
<head>
<title>Federal Register, Volume 90 Issue 228 (Monday, December 1, 2025)</title>
</head>
<body><pre>
[Federal Register Volume 90, Number 228 (Monday, December 1, 2025)]
[Notices]
[Pages 55108-55112]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2025-21673]


-----------------------------------------------------------------------

ENVIRONMENTAL PROTECTION AGENCY

[EPA-HQ-OPPT-2025-0067; FRL-12475-09-OCSPP]


Certain New Chemicals; Receipt and Status Information for August-
September 2025

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of receipt and request for comment.

-----------------------------------------------------------------------

SUMMARY: This document announces the Agency's receipt of new chemical 
submissions under the Toxic Substances Control Act (TSCA), including 
information about the receipt of a Premanufacture Notice (PMN), 
Significant New Use Notice (SNUN), Microbial Commercial Activity Notice 
(MCAN), and an amendment to a previously submitted notice; test 
information; a biotechnology exemption application; an application for 
a test marketing exemption (TME); and a notice of commencement of 
manufacture (defined by statute to include import) (NOC) for a new 
chemical substance. This document also provides a periodic status 
report on the new chemical substances that are currently under EPA 
review or have recently concluded review. EPA is hereby providing 
notice of receipt of this information, as required by TSCA, and an 
opportunity to comment. This document covers the period from 9/1/2025 
to 9/30/2025.

DATES: Comments must be received on or before December 31, 2025.

ADDRESSES: Submit your comments, identified by docket identification 
(ID) number EPA-HQ-OPPT-2025-0067 and the specific case number provided 
in this document for the chemical substance related to your comment, 
online at <a href="https://www.regulations.gov">https://www.regulations.gov</a>. Follow the online instructions 
for submitting comments. Do not submit electronically any information 
you consider to be Confidential Business Information (CBI) or other 
information whose disclosure is restricted by statute. Additional 
instructions on commenting and visiting the docket, along with more 
information about dockets generally, is available at <a href="https://www.epa.gov/dockets">https://www.epa.gov/dockets</a>.

FOR FURTHER INFORMATION CONTACT: 
    For technical information: Jim Rahai, Project Management and 
Operations Division (7407M), Office of Pollution Prevention and Toxics, 
Environmental Protection Agency, 1200 Pennsylvania Ave. NW, Washington, 
DC 20460-0001; telephone number: (202) 564-8593; email address: 
<a href="/cdn-cgi/l/email-protection#a8dac9c0c9c186c2c1c5e8cdd8c986cfc7de"><span class="__cf_email__" data-cfemail="196b7871787037737074597c6978377e766f">[email&#160;protected]</span></a>.
    For general information: The TSCA Assistance Information Service 
Hotline, Goodwill of the Finger Lakes, 422 South Clinton Ave., 
Rochester, NY 14620; telephone number: (800) 471-7125 or (202) 554-
1404; email address: <a href="/cdn-cgi/l/email-protection#4f1b1c0c0e6207203b2326212a0f2a3f2e61282039"><span class="__cf_email__" data-cfemail="b4e0e7f7f599fcdbc0d8dddad1f4d1c4d59ad3dbc2">[email&#160;protected]</span></a>.

SUPPLEMENTARY INFORMATION:

I. Executive Summary

A. Does this action apply to me?

    This action provides information that is directed to the public in 
general.

B. What is the Agency's authority for taking this action?

    EPA is publishing this document in the Federal Register as required 
by sections 5 of the Toxic Substances Control Act (TSCA), 15 U.S.C. 
2601 et seq., and corresponding EPA regulations.
    Under TSCA, a chemical substance may be either an ``existing'' 
chemical substance or a ``new'' chemical substance, see <a href="https://www.epa.gov/chemicals-under-tsca">https://www.epa.gov/chemicals-under-tsca</a>. Any chemical substance that is not on 
EPA's TSCA Inventory of Chemical Substances (TSCA Inventory) is 
classified as a ``new chemical substance,'' while a chemical substance 
that is listed on the TSCA Inventory is classified as an ``existing 
chemical substance.'' See TSCA section 3(2) and (11). For more 
information about the TSCA Inventory, see <a href="https://www.epa.gov/inventory">https://www.epa.gov/inventory</a>.
    Any person who intends to manufacture (including import) a new 
chemical substance for a non-exempt commercial purpose, or to 
manufacture or process a chemical substance in a non-exempt manner for 
a use that EPA

[[Page 55109]]

has determined is a significant new use, is required by TSCA section 5 
to provide EPA with a PMN, MCAN, or SNUN, as appropriate, before 
initiating the activity. EPA will review the notice, make a risk 
determination on the new chemical substance or significant new use, and 
take appropriate action as described in TSCA section 5(a)(3).
    TSCA section 5(h)(1) authorizes EPA to allow persons, upon 
application and under appropriate restrictions, to manufacture a new 
chemical substance, or manufacture or process a chemical substance 
subject to a significant new use rule (SNUR) issued under TSCA section 
5(a)(2), for ``test marketing'' purposes, upon a showing that the 
manufacture, processing, distribution in commerce, use, and disposal of 
the chemical substances will not present an unreasonable risk of injury 
to health or the environment. This is referred to as a test marketing 
exemption, or TME.
    Premanufacture notification procedures for review of certain new 
microbial products of biotechnology are established in 40 CFR part 725. 
These pertain to MCANs and biotechnology exemptions, including TSCA 
experimental release applications (TERAs), TMEs for microorganisms, and 
Tier I and Tier II exemptions.

C. What action is the Agency taking?

    This document provides notice of receipt and status reports for the 
covered period and certain submissions under TSCA section 5 and 
provides an opportunity to comment on this information. The Agency is 
providing information about the receipt of PMNs, SNUNs, MCANs, and 
amendments to a previously submitted notice; test information; 
biotechnology exemption applications under 40 CFR part 725; TME 
applications; NOCs for new chemical substances; and a periodic status 
report on chemical substances that are currently under EPA review or 
have recently concluded review.

D. What should I consider as I prepare my comments for EPA?

    1. Submitting CBI. Do not submit CBI to EPA through <a href="https://www.regulations.gov">https://www.regulations.gov</a> or email. If you wish to include CBI in your 
comment, please follow the instructions at <a href="https://www.epa.gov/dockets/commenting-epa-dockets#rules">https://www.epa.gov/dockets/commenting-epa-dockets#rules</a> and clearly mark the information that you 
claim to be CBI. In addition to one complete version of the comment 
that includes CBI, a copy of the comment without CBI must be submitted 
for inclusion in the public docket. Information marked as CBI will not 
be disclosed except in accordance with procedures set forth in 40 CFR 
parts 2 and 703.
    2. Tips for preparing your comments. When preparing and submitting 
your comments, see the commenting tips at <a href="https://www.epa.gov/dockets/commenting-epa-dockets">https://www.epa.gov/dockets/commenting-epa-dockets</a>.

II. Background

A. What information is being provided in this document?

    The tables in this document provide the following information on 
the TSCA section 5 submissions received by EPA during this period and 
determined to be complete consistent with 40 CFR 720.70(a).
    <bullet> Case number. The EPA number assigned to the TSCA section 5 
submissions. Please note that a case number may be listed more than 
once in the table when the submission involves a subsequent amendment.
    <bullet> Chemical substance. Name of the chemical substance, or 
generic name if the specific name is claimed as CBI.
    <bullet> Manufacturer. Name of the submitting manufacturer, to the 
extent that such information is not subject to a CBI claim. The term 
``manufacturer'' is defined by statute to include importer.
    <bullet> Use(s). Potential uses identified by the manufacturer.
    <bullet> Received. Date the submission was received by EPA.
    <bullet> Commencement. Date of commencement provided by the 
submitter in the NOC.
    <bullet> Test information. For test information received, the type 
of test information submitted to EPA based on the attachment type and 
subtype data selected by the submitter.

B. What do the acronyms mean that are used in the tables?

    As used in each of the tables, the following explanations apply:
    <bullet> (S) indicates that the information in the table is the 
specific information provided by the submitter.
    <bullet> (G) indicates that the information in the table is generic 
information because the specific information provided by the submitter 
was claimed as CBI.

C. How can I access other information about TSCA section 5 submissions?

    EPA provides information on its website about cases reviewed under 
TSCA section 5, including the PMNs, SNUNs, MCANs, and exemption 
applications received; the date of receipt; the final EPA determination 
on the submission; and the effective date of EPA's determination. See 
<a href="https://www.epa.gov/new-chemicals-under-toxic-substances-control-act-tsca/status-pre-manufacture-notices">https://www.epa.gov/new-chemicals-under-toxic-substances-control-act-tsca/status-pre-manufacture-notices</a>. In addition, information EPA 
receives about chemical substances under TSCA, including non-CBI new 
chemical submissions, can be accessed in ChemView at <a href="https://chemview.epa.gov/">https://chemview.epa.gov/</a> gov/.

III. Receipt Reports

    Table 1 provides non-CBI information for the PMNs, SNUNs and MCANs 
received by EPA that have passed an initial screening and determined to 
be complete consistent with 40 CFR 720.70(a) during this period.

                                Table 1--PMN/SNUN/MCANs Received and Under Review
----------------------------------------------------------------------------------------------------------------
                          Received
       Case No.             date              Manufacturer                   Use            Chemical substance
----------------------------------------------------------------------------------------------------------------
J-25-0011A............   09/16/2025  CBI...........................  (G) Fermentation    (G) Escherichia coli
                                                                      to produce base     (gene edited)
                                                                      chemical.           containing 8
                                                                                          integrated genes.
J-25-0015.............   09/21/2025  Danisco US, Inc...............  (G) Production of   (G) Genetically
                                                                      a chemical          modified
                                                                      substance.          microorganism.
P-19-0140.............   08/29/2025  CBI...........................  (G) Intermediate..  (G) Perfluorodioxaalkyl
                                                                                          vinyl ether.
P-20-0034.............   08/29/2025  CBI...........................  (G) Intermediate..  (G) Perfluorinated
                                                                                          vinyl haloalkane
                                                                                          sulfonyl halide.
P-23-0138.............   09/02/2025  IGM Resins Charlotte, Inc.....  (S) Photo           (S) Benzoic acid, 2-
                                                                      initiator: Amine    ([1,1'-biphenyl]-4-
                                                                      Synergists or       ylcarbonyl)-, 2-
                                                                      Amine Acrylates     ethylhexyl ester.
                                                                      like OPV and
                                                                      industrial
                                                                      coatings
                                                                      (pigmented
                                                                      systems like
                                                                      offset, flexo and
                                                                      inkjets.
P-23-0162.............   09/24/2025  CBI...........................  (S) Transportation  (G) Alkane
                                                                      fuels, Chemical     (glyceridic),
                                                                      Feedstock, Fuel     hydrotreated and
                                                                      additive.           isomerized.
P-24-0093.............   09/03/2025  Evonik Corporation............  (S) Surfactant in   (G) Rhamnolipids,
                                                                      laundry             modified pseudomonas-
                                                                      detergent, hard     fermented, from
                                                                      surface cleaner,    dextrose, salts.
                                                                      manual/hand dish
                                                                      detergent.

[[Page 55110]]

 
P-24-0094.............   09/03/2025  Evonik Corporation............  (S) Surfactant in   (G) Rhamnolipids,
                                                                      laundry             modified pseudomonas-
                                                                      detergent, hard     fermented, from
                                                                      surface cleaner,    dextrose, salts.
                                                                      manual/hand dish
                                                                      detergent.
P-24-0095.............   09/03/2025  Evonik Corporation............  (S) Surfactant in   (G) Rhamnolipids,
                                                                      laundry             modified pseudomonas-
                                                                      detergent, hard     fermented, from
                                                                      surface cleaner,    dextrose, salts.
                                                                      manual/hand dish
                                                                      detergent.
P-24-0096.............   09/03/2025  Evonik Corporation............  (S) Surfactant in   (G) Rhamnolipids,
                                                                      laundry             modified pseudomonas-
                                                                      detergent, hard     fermented, from
                                                                      surface cleaner,    dextrose, salts.
                                                                      manual/hand dish
                                                                      detergent.
P-24-0144.............   09/11/2025  CBI...........................  (G) Industrial Raw  (G) Unsaturated
                                                                      Material.           carboxylic acid
                                                                                          copolymer with 2-
                                                                                          Methyl substituted
                                                                                          poly (ethylene glycol)
                                                                                          diol.
P-24-0144.............   09/24/2025  CBI...........................  (G) Industrial Raw  (G) Unsaturated
                                                                      Material.           carboxylic acid
                                                                                          copolymer with 2-
                                                                                          Methyl substituted
                                                                                          poly (ethylene glycol)
                                                                                          diol.
P-25-0023.............   09/18/2025  CBI...........................  (G) Mixed metal     (G) Cobalt lithium
                                                                      oxide for           manganese nickel
                                                                      batteries.          oxide, metals-
                                                                                          modified.
P-25-0039.............   09/03/2025  CBI...........................  (G) Component in    (G) Polysiloxane
                                                                      marine coatings.    modified polyacrylic
                                                                                          metal carboxylate
                                                                                          complex.
P-25-0073.............   09/04/2025  CBI...........................  (G) Substance for   (G) Cobalt lithium
                                                                      the use in          manganese nickel
                                                                      manufacturing of    oxide, metals.
                                                                      battery
                                                                      components..
P-25-0093.............   09/22/2025  CBI...........................  (G) Battery         (G) Mixed Metal Oxide.
                                                                      Component.
P-25-0094.............   09/22/2025  CBI...........................  (G) Battery         (G) Mixed Metal Oxide.
                                                                      Component.
P-25-0095.............   09/22/2025  CBI...........................  (G) Battery         (G) Mixed Metal Oxide.
                                                                      Component.
P-25-0096.............   09/22/2025  CBI...........................  (G) Battery         (G) Mixed Metal Oxide.
                                                                      Component.
P-25-0118.............   09/09/2025  CBI...........................  (G) Liquid and      (G) Neutral Protease.
                                                                      solid formulation
                                                                      of biocatalyst
                                                                      used in a variety
                                                                      of products.
P-25-0123.............   09/03/2025  CBI...........................  (G) Ink component,  (G) Butanamide, 2,2'-
                                                                      Ingredient in ink.  [(dihalo[1,1'-
                                                                                          biphenyl]-4,4'-diyl)
                                                                                          bis(2,1-diazenediyl)]
                                                                                          bis [3-oxo, N,N'-
                                                                                          bis(substituted
                                                                                          heteropolycyclic and
                                                                                          alkyl carbomonocyclic)
                                                                                          derivs.
P-25-0129.............   09/19/2025  Hawkins, Inc..................  (S) Correction of   (S) Ferrate (3-), [[a,
                                                                      iron deficiency     a'-[1,2-
                                                                      in alkaline soils   ethanediyldi(imino-
                                                                      when EDTA-Fe is     kN)] bis[2-(hydroxy-
                                                                      not stable.         kO)-5-
                                                                      Product is          sulfobenzeneacetato-
                                                                      intended as a       kO]] (6-)]-, sodium
                                                                      fertilizer          (1:3).
                                                                      micronutrient.
P-25-0143.............   09/05/2025  DAY-GLO Color Corp............  (S) Polymer.......  (G) Zinc,
                                                                                          cycloaliphatic diamine-
                                                                                          isophthalic acid-2-
                                                                                          methyl-1,3-propanediol
                                                                                          polymer-phthalic
                                                                                          anhydride reaction
                                                                                          products complexes.
P-25-0143.............   09/16/2025  DAY-GLO Color Corp............  (S) Polymer         (G) Zinc,
                                                                      functions as a      cycloaliphatic diamine-
                                                                      carrier for dyes    isophthalic acid-2-
                                                                      and pigments. It    methyl-1,3-propanediol
                                                                      is subsequently     polymer-phthalic
                                                                      compounded with     anhydride reaction
                                                                      other polymers to   products complexes.
                                                                      impart color in
                                                                      finished
                                                                      products. End-use
                                                                      applications can
                                                                      include toys,
                                                                      apparel,
                                                                      footwear, and
                                                                      packaging
                                                                      materials.
P-25-0144.............   08/28/2025  CBI...........................  (G) Substance for   (G) Cobalt lithium
                                                                      the use in          manganese nickel
                                                                      manufacturing of    oxide, metals.
                                                                      battery
                                                                      components.
P-25-0145.............   08/28/2025  CBI...........................  (G) Substance for   (G) Cobalt lithium
                                                                      the use in          manganese nickel
                                                                      manufacturing of    oxide, metals.
                                                                      battery
                                                                      components.
P-25-0146.............   08/28/2025  CBI...........................  (G) Substance for   (G) Cobalt lithium
                                                                      the use in          manganese nickel
                                                                      manufacturing of    oxide, metals.
                                                                      battery
                                                                      components.
P-25-0147.............   08/29/2025  UBE C1 Chemicals America, Inc.  (G) Catalyst        (S) Aluminum lithium
                                                                      support.            oxide.
P-25-0148.............   09/25/2025  J6 Polymers...................  (S) Primary polyol  (S) Soybean oil,
                                                                      for the B-side      polymer with
                                                                      component of        diethylene glycol,
                                                                      spray foam          glycerol, phthalic
                                                                      polyurethane        anhydride,
                                                                      systems.            terephthalic acid and
                                                                                          triethylene glycol.
P-25-0149.............   09/05/2025  MGC Pure Chemicals America,     (S) Chelating       (G) Phosphonic acid,
                                      Inc.                            agent for use in    [(alkyl-alkanediyl)
                                                                      semiconductor       bis[nitrilobis(alkylen
                                                                      manufacture.        e)]].
P-25-0150.............   09/06/2025  SIKA Corporation..............  (S) Reactive        (G) 1,3-
                                                                      polymer for use     Benzenedicarboxylic
                                                                      in adhesive         acid, polymer with 1,4-
                                                                      applications.       benzenedicarboxylic
                                                                                          acid, substituted-
                                                                                          alkanediol,
                                                                                          alkanediol, and
                                                                                          alkanediol, alkanoic
                                                                                          acid and
                                                                                          arylcarboxylic acid
                                                                                          anhydride, bis[N-[4-
                                                                                          [(4-isocyanatophenyl)
                                                                                          methyl] phenyl]
                                                                                          carbamate].
P-25-0150.............   09/15/2025  SIKA Corporation..............  (S) Reactive        (G) 1,3-
                                                                      polymer for use     Benzenedicarboxylic
                                                                      in adhesive         acid, polymer with 1,4-
                                                                      applications.       benzenedicarboxylic
                                                                                          acid, substituted-
                                                                                          alkanediol,
                                                                                          alkanediol, and
                                                                                          alkanediol, alkanoic
                                                                                          acid and
                                                                                          arylcarboxylic acid
                                                                                          anhydride, bis[N-[4-
                                                                                          [(4-isocyanatophenyl)
                                                                                          methyl] phenyl]
                                                                                          carbamate].
P-25-0151.............   09/13/2025  CBI...........................  (G) Substance for   (G) Cobalt lithium
                                                                      the use in          manganese nickel
                                                                      manufacturing of    oxide, metals.
                                                                      battery
                                                                      components.
P-25-0152.............   09/13/2025  CBI...........................  (G) Substance for   (G) Cobalt lithium
                                                                      the use in          manganese nickel
                                                                      manufacturing of    oxide, metals.
                                                                      battery
                                                                      components.

[[Page 55111]]

 
P-25-0153.............   09/19/2025  Schimmer & Schwarz............  (S) ATIEL-ATC       (G) Mixture of Fatty
                                                                      Group B [i]         acids esters with
                                                                      General             isomerized alkane
                                                                      industrial use of   derivs.
                                                                      lubricants and
                                                                      greases in
                                                                      vehicles or
                                                                      machinery.
                                                                      Includes filling
                                                                      and draining of
                                                                      containers and
                                                                      enclosed
                                                                      machinery
                                                                      (including
                                                                      engines); ATIEL-
                                                                      ATC Group F [i]
                                                                      Industrial Use of
                                                                      lubricants in
                                                                      high energy open
                                                                      processes.
                                                                      Including high
                                                                      speed machinery
                                                                      such as metal
                                                                      rolling/forming
                                                                      or metalworking
                                                                      fluids for
                                                                      machining and
                                                                      grinding; ATIEL-
                                                                      ATC Group E [i]
                                                                      Industrial
                                                                      Handling and
                                                                      dilution of
                                                                      metalworking
                                                                      fluid
                                                                      concentrates.
P-25-0154.............   09/19/2025  Schimmer & Schwarz............  (S) ATIEL-ATC       (G) Mixture of fatty
                                                                      Group B [i]         acids esters with
                                                                      General             isomerized alkane
                                                                      industrial use of   derivs.
                                                                      lubricants and
                                                                      greases in
                                                                      vehicles or
                                                                      machinery.
                                                                      Includes filling
                                                                      and draining of
                                                                      containers and
                                                                      enclosed
                                                                      machinery
                                                                      (including
                                                                      engines); ATIEL-
                                                                      ATC Group F [i]
                                                                      Industrial Use of
                                                                      lubricants in
                                                                      high energy open
                                                                      processes.
                                                                      Including high
                                                                      speed machinery
                                                                      such as metal
                                                                      rolling/forming
                                                                      or metalworking
                                                                      fluids for
                                                                      machining and
                                                                      grinding; ATIEL-
                                                                      ATC Group E [i]
                                                                      Industrial
                                                                      Handling and
                                                                      dilution of
                                                                      metalworking
                                                                      fluid
                                                                      concentrates.
P-25-0155.............   09/19/2025  Schimmer & Schwarz............  (S) ATIEL-ATC       (G) Mixture of Fatty
                                                                      Group B [i]         acids esters with
                                                                      General             isomerized alkane
                                                                      industrial use of   derivs.
                                                                      lubricants and
                                                                      greases in
                                                                      vehicles or
                                                                      machinery.
                                                                      Includes filling
                                                                      and draining of
                                                                      containers and
                                                                      enclosed
                                                                      machinery
                                                                      (including
                                                                      engines); ATIEL-
                                                                      ATC Group F [i]
                                                                      Industrial Use of
                                                                      lubricants in
                                                                      high energy open
                                                                      processes.
                                                                      Including high
                                                                      speed machinery
                                                                      such as metal
                                                                      rolling/forming
                                                                      or metalworking
                                                                      fluids for
                                                                      machining and
                                                                      grinding; ATIEL-
                                                                      ATC Group E [i]
                                                                      Industrial
                                                                      Handling and
                                                                      dilution of
                                                                      metalworking
                                                                      fluid
                                                                      concentrates.
P-25-0156.............   09/16/2025  CBI...........................  (G) Adhesive        (G) Alkyl alkanol,
                                                                      hardener,           reaction products with
                                                                      Microcapsule.       1,5-
                                                                                          diisocyanatopentane.
P-25-0158.............   09/25/2025  BEDOUKIAN RESEARCH, INC.......  (S) Site-limited    (G)
                                                                      intermediate.       Triarylalkylphosphoniu
                                                                                          m halide salt.
P-25-0160.............   09/29/2025  CBI...........................  (G)                 (G) Sulfonium,
                                                                      Photolithography.   tricarbocyclic-,
                                                                                          heteroatom-substituted-
                                                                                          carbomonocyclecarbonat
                                                                                          e (1:1).
P-25-0161.............   09/29/2025  CBI...........................  (G)                 (G) Sulfonium,
                                                                      Photolithography.   tricarbocyclic-, 2-(4-
                                                                                          heteroatom-substituted-
                                                                                          halocarbomonocyclic)-
                                                                                          alpha, alpha, beta,
                                                                                          beta-
                                                                                          polyfluoropolyhydro-
                                                                                          4,7-methano-1,3-
                                                                                          heteropolycyclic-5-
                                                                                          alkanesulfonate (1:1).
P-25-0162.............   09/29/2025  CBI...........................  (G)                 (G) Sulfonium,
                                                                      Photolithography.   tricarbocyclic-,
                                                                                          perfluoroalkyl-
                                                                                          substituted and
                                                                                          heteroatom-substituted-
                                                                                          carbomonocyclecarbonat
                                                                                          e (1:1).
P-25-0163.............   09/29/2025  CBI...........................  (G)                 (G) Sulfonium,
                                                                      Photolithography.   tricarbocyclic-, 5-
                                                                                          [polyhydro-2-alkyl-5-
                                                                                          (1,1,2,2-polyfluoro-2-
                                                                                          sulfoalkyl)-4,7-
                                                                                          methano-1,3-
                                                                                          heteropolycyclic-2-yl]-
                                                                                          2-heteroatom-
                                                                                          substituted-
                                                                                          carbomonocyclic acid
                                                                                          (1:1).
SN-25-0010............   09/08/2025  Solstice Advanced Materials     (S) MVAC:           (S) 1-Propene, 2,3,3,3-
                                      US, Inc.                        Passenger Air       tetrafluoro-.
                                                                      Conditioning in
                                                                      light duty
                                                                      vehicles that
                                                                      were previously
                                                                      using R-134a as
                                                                      their
                                                                      refrigerant: 1.
                                                                      light-duty
                                                                      vehicles (e.g.,
                                                                      passenger cars),
                                                                      2. light-duty
                                                                      trucks (e.g.,
                                                                      minivans, full
                                                                      size pick-up
                                                                      trucks, and full-
                                                                      size SUVs) 3.
                                                                      medium-duty
                                                                      passenger
                                                                      vehicles, heavy-
                                                                      duty pickup
                                                                      trucks, complete
                                                                      heavy-duty vans.
----------------------------------------------------------------------------------------------------------------


[[Page 55112]]

    Table 2 provides non-CBI information on the NOCs received by EPA 
that have passed an initial screening during this period.

                                     Table 2--NOCs Received and Under Review
----------------------------------------------------------------------------------------------------------------
                                              Received    Commencement
                 Case No.                       date          date                  Chemical substance
----------------------------------------------------------------------------------------------------------------
P-22-0035.................................   09/16/2025      09/11/2025  (G) Alkenoic acid, alkanediyl ester,
                                                                          polymer with bis (substituted alkyl)-
                                                                          alkanediol polymer with alkylene
                                                                          oxides alkenoate, and alkanamine.
P-22-0114.................................   08/29/2025      08/27/2025  (S) Edge-oxidized graphene.
P-23-0087.................................   09/03/2025      08/21/2025  (S) Oxirane, 2-methyl-, polymer with 2-
                                                                          [[3-(triethoxysilyl) propoxy] methyl]
                                                                          oxirane, monoether with -butyl-
                                                                          hydroxypoly[oxy(methyl-1,2-
                                                                          ethanediyl)].
P-23-0169.................................   09/05/2025      09/03/2025  (G) Alkane, bis(chlorosilane),.
P-25-0097.................................   09/18/2025      09/15/2025  (G) Aromatic sulfonium tricyclo salt
                                                                          with dicycloalkyl carbomonocycle
                                                                          hetero acid.
----------------------------------------------------------------------------------------------------------------

    Table 3 provides non-CBI information on the test information that 
has been received by EPA that have passed an initial screening during 
this period.

                   Table 3--Test Information Received
------------------------------------------------------------------------
                           Received     Type of test        Chemical
        Case No.             date        information        substance
------------------------------------------------------------------------
P-19-0166..............   09/23/2025  Photo             (G) Triaryl
                                       transformation    sulfonium,
                                       of Chemicals in   multicycloalkyl
                                       Water--Direct     alkoxycarbonylo
                                       Photolysis        xymonofluoroalk
                                       (OECD Test        ylsulfonate.
                                       Guideline 316);
                                       Partition
                                       Coefficient (1-
                                       Octanol/Water):
                                       Slow-Stirring
                                       Method (OECD
                                       Test Guideline
                                       123).
P-22-0042..............   09/18/2025  Combined          (G)
                                       Repeated Does     Alkanediones,
                                       Toxicity Study    [[[(substituted
                                       with the          )aryl] thio]
                                       Reproduction/     aryl]-, 2-(O-
                                       Developmental     acetyloxime).
                                       Toxicity
                                       Screening Test
                                       (OECD Test
                                       Guideline 422).
P-23-0093, P-24-0190, P-  09/29/2025  Notice of Study   (G) Aromatic
 24-0160.                              Scheduling.       Dibenz
                                                         thiophenium
                                                         fluoroalkyl
                                                         carbopolycycle
                                                         sulfonic acid
                                                         salt; (G)
                                                         Aromatic
                                                         sulfonium
                                                         tricyclo salt
                                                         with alkyl
                                                         carbomonocycle
                                                         hetero-acid;
                                                         (G) Iodonium,
                                                         bis (dialkyl
                                                         carbomonocycle)
                                                         salt with alkyl
                                                         carbomonocycle
                                                         hetero-acid,.
P-23-0037, P-23-0080, P-  09/29/2025  Notice of Study   (G) Monoaromatic
 23-0044.                              Scheduling.       cyclic alkylene
                                                         sulfonium
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt; (G)
                                                         Aromatic
                                                         sulfonium
                                                         tricyclo
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt; (G)
                                                         Monoaromatic
                                                         cyclic alkylene
                                                         sulfonium
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt.
P-25-0016, P-22-0055, P-  09/11/2025  Notice of Study   (G) Tri
 20-0042.                              Scheduling.       haloaromatic
                                                         iodonium
                                                         dicyclo salt
                                                         with
                                                         polyhaloalkyl
                                                         carbomonocycle
                                                         hetero-acid;
                                                         (G) Aromatic
                                                         sulfonium
                                                         tricyclo
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt; (G)
                                                         Sulfonium,
                                                         trisaryl-, 7,7-
                                                         dialkyl-2-
                                                         heteropolycycli
                                                         c -1-
                                                         alkanesulfonate
                                                         (1:1).
P-23-0093, P-24-0190, P-  09/11/2025  Notice of Study   (G) Aromatic
 23-0160.                              Scheduling.       Dibenz
                                                         thiophenium
                                                         fluoroalkyl
                                                         carbopolycycle
                                                         sulfonic acid
                                                         salt; (G)
                                                         Aromatic
                                                         sulfonium
                                                         tricyclo salt
                                                         with alkyl
                                                         carbomonocycle
                                                         hetero-acid;
                                                         (G) Iodonium,
                                                         bis (dialkyl
                                                         carbomonocycle)
                                                         salt with alkyl
                                                         carbomonocycle
                                                         hetero-acid,.
P-23-0037, P-23-0080, P-  09/11/2025  Notice of Study   (G) Monoaromatic
 23-0044.                              Scheduling.       cyclic alkylene
                                                         sulfonium
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt; (G)
                                                         Aromatic
                                                         sulfonium
                                                         tricyclo
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt; (G)
                                                         Monoaromatic
                                                         cyclic alkylene
                                                         sulfonium
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt.
P-18-0016..............   09/11/2025  Notice of Study   (G) Aromatic
                                       Scheduling.       sulfonium
                                                         tricyclo
                                                         fluoroalkyl
                                                         sulfonic acid
                                                         salt.
P-22-0014..............   09/04/2025  Clarification     (G) Sodium
                                       Request           bis(chloropropa
                                       Regarding MOE     nediol)
                                       and POD Used in   phosphate.
                                       PMN Risk
                                       Assessment
                                       Referencing
                                       Read-Across
                                       Substance TCEP
                                       (CASRN 115-96-
                                       8).
------------------------------------------------------------------------

IV. Status Reports

    Information about the TSCA section 5 PMNs, SNUNs, MCANs, and 
exemption applications received, including the date of receipt, the 
status of EPA's review, the final EPA determination, and the effective 
date of EPA's determination, is available online at: <a href="https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca/status-pre-manufacture-notices">https://www.epa.gov/reviewing-new-chemicals-under-toxic-substances-control-act-tsca/status-pre-manufacture-notices</a>.
    Authority: 15 U.S.C. 2601 et seq.

    Dated: November 25, 2025.
Mary Elissa Reaves,
Director, Office of Pollution Prevention and Toxics.
[FR Doc. 2025-21673 Filed 11-28-25; 8:45 am]
BILLING CODE 6560-50-P


</pre><script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script></body>
</html>
Indexed from Federal Register on December 1, 2025.

This is legal information, not legal advice. Laws vary by jurisdiction and change frequently. Always verify current law with official sources and consult a licensed attorney in your jurisdiction for advice on your specific situation.