Notice2025-21183
Bulk Manufacturer of Controlled Substances Application: Cayman Chemical Company
Primary source
Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.
Published
November 26, 2025
Issuing agencies
Justice DepartmentDrug Enforcement Administration
Abstract
Cayman Chemical Company has applied to be registered as a bulk manufacturer of basic class(es) of controlled substance(s). Refer to SUPPLEMENTARY INFORMATION listed below for further drug information.
Full Text
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<title>Federal Register, Volume 90 Issue 226 (Wednesday, November 26, 2025)</title>
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[Federal Register Volume 90, Number 226 (Wednesday, November 26, 2025)]
[Notices]
[Pages 54380-54385]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2025-21183]
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DEPARTMENT OF JUSTICE
Drug Enforcement Administration
[Docket No. DEA-1593]
Bulk Manufacturer of Controlled Substances Application: Cayman
Chemical Company
AGENCY: Drug Enforcement Administration, Justice.
ACTION: Notice of application.
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SUMMARY: Cayman Chemical Company has applied to be registered as a bulk
manufacturer of basic class(es) of controlled substance(s). Refer to
SUPPLEMENTARY INFORMATION listed below for further drug information.
DATES: Registered bulk manufacturers of the affected basic class(es),
and applicants, therefore, may submit electronic comments on or
objections to the issuance of the proposed registration on or before
January 26, 2026. Such persons may also file a written request for a
hearing on the application on or before January 26, 2026.
ADDRESSES: The Drug Enforcement Administration requires that all
comments be submitted electronically through the Federal eRulemaking
Portal,
[[Page 54381]]
which provides the ability to type short comments directly into the
comment field on the web page or attach a file for lengthier comments.
Please go to <a href="https://www.regulations.gov">https://www.regulations.gov</a> and follow the online
instructions at that site for submitting comments. Upon submission of
your comment, you will receive a Comment Tracking Number. Please be
aware that submitted comments are not instantaneously available for
public view on <a href="https://www.regulations.gov">https://www.regulations.gov</a>. If you have received a
Comment Tracking Number, your comment has been successfully submitted
and there is no need to resubmit the same comment.
SUPPLEMENTARY INFORMATION: In accordance with 21 CFR 1301.33(a), this
is notice that on August 20, 2025, Cayman Chemical Company, 1180 East
Ellsworth Road, Ann Arbor, Michigan 48108-2419, applied to be
registered as a bulk manufacturer of the following basic class(es) of
controlled substance(s):
------------------------------------------------------------------------
Drug
Controlled substance code Schedule
------------------------------------------------------------------------
3-Fluoro-N-methylcathinone (3-FMC)........... 1233 I
Cathinone.................................... 1235 I
Methcathinone................................ 1237 I
4-Fluoro-N-methylcathinone (4-FMC) 1238 I N.. 1238 I
Para-Methoxymethamphetamine (PMMA), 1-(4- 1245 I
methoxyphenyl)-N-methylpropan-2-amine.
Pentedrone ([alpha]-methylaminovalerophenone) 1246 I
Mephedrone (4-Methyl-N-methylcathinone)...... 1248 I
4-Methyl-N-ethylcathinone (4-MEC)............ 1249 I
Naphyrone.................................... 1258 I
3-methylmethcathinone (2-(methylamino)-1-(3- 1259 I
methylphenyl)propan-1-one).
N-Ethylamphetamine........................... 1475 I
Methiopropamine (N-methyl-1-(thiophen-2- 1478 I
yl)propan-2-amine) 1478 I N.
N,N-Dimethylamphetamine...................... 1480 I
Fenethylline................................. 1503 I
Aminorex..................................... 1585 I
4-Methylaminorex (cis isomer)................ 1590 I
4,4'-Dimethylaminorex (4,4'-DMAR; 4,5-dihydro- 1595 I
4-1595 I N methyl-5-(4-methylphenyl)-2-
oxazolamine; 4-methyl-5-(4-methylphenyl)-4,5-
dihydro-1,3-oxazol-2-amine).
Gamma Hydroxybutyric Acid.................... 2010 I
Methaqualone................................. 2565 I
Mecloqualone................................. 2572 I
Etizolam (4-(2-chlorophenyl)-2-ethyl-9-methyl- 2780 I
6Hthieno[3,2-f][1,2,4]triazolo[4,3-
a][1,4]diazepine.
Flualprazolam (8-chloro-6-(2-fluorophenyl)-1- 2785 I
methyl-4Hbenzo[f][1,2,4]triazolo[4,3-
a][1,4]diazepine).
Clonazolam (6-(2-chlorophenyl)-1-methyl-8- 2786 I
nitro-4Hbenzo[f][1,2,4]triazolo[4,3-
a][1,4]diazepine.
Flubromazolam (8-bromo-6-(2-fluorophenyl)-1- 2788 I
methyl4H-benzo[f][1,2,4]triazolo[4,3-
a][1,4]diazepine.
Diclazepam (7-chloro-5-(2-chloro-5-(2- 2789 I
chlorophenyl)-1-methyl-1,3-dihydro-2H-
benzo[e][1,4]diazepin-2-one.
JWH-250 (1-Pentyl-3-(2- 6250 I
methoxyphenylacetyl)indole).
SR-18 (Also known as RCS-8) (1- 7008 I
Cyclohexylethyl-3-(2-methoxyphenylacetyl)
indole).
ADB-FUBINACA (N-(1-amino-3,3-dimethyl-1- 7010 I
oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-
indazole-3-carboxamide).
5-Fluoro-UR-144 and XLR11 [1-(5-Fluoro- 7011 I
pentyl)1H-indol-3-yl](2,2,3,3-
tetramethylcyclopropyl)methanone.
AB-FUBINACA (N-(1-amino-3-methyl-1-oxobutan-2- 7012 I
yl)-1-(4-fluorobenzyl)-1H-indazole-3-
carboxamide).
FUB-144 (1-(4-fluorobenzyl)-1H-indol-3- 7014 I
yl)(2,2,3,3-
tetramethylcyclopropyl)methanone).
JWH-019 (1-Hexyl-3-(1-naphthoyl)indole)...... 7019 I
MDMB-FUBINACA (Methyl 2-(1-(4-fluorobenzyl)- 7020 I
1H-indazole-3-carboxamido)-3,3-
dimethylbutanoate).
FUB-AMB, MMB-FUBINACA, AMB-FUBINACA (2-(1-(4- 7021 I
fluorobenzyl)-1Hindazole-3-carboxamido)-3-
methylbutanoate).
AB-PINACA (N-(1-amino-3-methyl-1-oxobutan-2- 7023 I
yl)-1-pentyl-1H-indazole-3-carboxamide).
THJ-2201 ([1-(5-fluoropentyl)-1H-indazol-3- 7024 I
yl](naphthalen-1-yl)methanone).
5F-AB-PINACA (N-(1-amino-3-methyl-1-oxobutan- 7025 I
2-yl)-1-(5-fluropentyl)-1H-indazole-3-
carboximide).
ADB-BUTINACA (N-(1-amino-3,3-dimethyl-1- 7027 I
oxobutan2-yl)-1-butyl-1H-indazole-3-
carboxamide).
AB-CHMINACA (N-(1-amino-3-methyl-1-oxobutan-2- 7031 I
yl)-1-(cyclohexylmethyl)-1H-indazole-3-
carboxamide).
MAB-CHMINACA (N-(1-amino-3,3dimethyl-1- 7032 I
oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-
indazole-3-carboxamide).
5F-AMB (Methyl 2-(1-(5-fluoropentyl)-1H- 7033 I
indazole-3-carboxamido)-3-methylbutanoate).
5F-ADB, 5F-MDMB-PINACA (Methyl 2-(1-(5- 7034 I
fluoropentyl)-1H-indazole-3-carboxamido)-3,3-
dimethylbutanoate).
ADB-PINACA (N-(1-amino-3,3-dimethyl-1- 7035 I
oxobutan-2-yl)-1-pentyl-1H-indazole-3-
carboxamide).
5F-EDMB-PINACA (ethyl 2-(1-(5-fluoropentyl)- 7036 I
1H-indazole-3-carboxamido)-3,3-
dimethylbutanoate).
5F-MDMB-PICA (methyl 2-(1-(5-fluoropentyl)-1H- 7041 I
indole-3-carboxamido)-3,3-dimethylbutanoate).
MDMB-CHMICA, MMB-CHMINACA (Methyl 2-(1- 7042 I
(cyclohexylmethyl)-1H-indole-3-carboxamido)-
3,3-dimethylbutanoate).
4F-MDMB-BINACA (4F-MDMB-BUTINACA or methyl 2- 7043 I
(1-(4-fluorobutyl)-1H-indazole-3-
carboxamido)-3,3-dimethylbutanoate) 7043 I N.
MMB-CHMICA, AMB-CHMICA (methyl 2-(1- 7044 I
(cyclohexylmethyl)-1H-indole-3-carboxamido)-
3-methylbutanoate).
FUB-AKB48, FUB-APINACA, AKB48 N-(4- 7047 I
FLUOROBENZYL) (N-(adamantan-1-yl)-1-(4-
fluorobenzyl)-1H-indazole-3-carboximide).
APINACA and AKB48 (N-(1-Adamantyl)-1-pentyl- 7048 I
1H-indazole-3-carboxamide).
5F-APINACA, 5F-AKB48 (N-(adamantan-1-yl)-1-(5- 7049 I
fluoropentyl)-1H-indazole-3-carboxamide).
JWH-081 (1-Pentyl-3-(1-(4-methoxynaphthoyl) 7081 I
indole).
5F-CUMYL-PINACA, 5GT-25 (1-(5-fluoropentyl)-N- 7083 I
(2-phenylpropan-2-yl)-1H-indazole-3-
carboxamide).
5F-CUMYL-P7AICA (1-(5-fluoropentyl)-N-(2- 7085 I
phenylpropan-2-yl)-1H-pyrrolo[2,3-b]pyridine-
3-carboxamide).
4-CN-CUML-BUTINACA, 4-cyano-CUMYL-BUTINACA, 4- 7089 I
CN-CUMYL BINACA, CUMYL-4CN-BINACA, SGT-78 (1-
(4-cyanobutyl)-N-(2-phenylpropan-2-yl)-1H-
indazole-3-carboxamide).
MDMB-4en-PINACA (methyl 3,3-dimethyl-2-(1- 7090 I
(pent-4-en-1-yl)-1H-indazole-3-
carboxamido)butanoate).
4F-MDMB-BUTICA (methyl 2-[[1-(4- 7091 I
fluorobutyl)indole-3-carbonyl]amino]-3,3-
dimethyl-butanoate.
ADB-4en-PINACA (N-(1-amino-3,3-dimethyl-1- 7092 I
oxobutan-2-yl)-1-(pent-4-en-1-yl)-1H-
indazole-3-carboxamide).
[[Page 54382]]
CUMYL-PEGACLONE (5-pentyl-2-(2-phenylpropan-2- 7093 I
yl)pyrido[4,3-b]indol-1-one).
5F-EDMB-PICA (ethyl 2-[[1-(5- 7094 I
fluorophentyl)indole-3-carbonyl]amino]-3,3-
dimethyl-butanoate.
MMB-FUBICA (methyl 2-(1-(4-fluorobenzyl)-1H- 7095 I
indole3-carboxamido)-3-methyl butanoate.
SR-19 (Also known as RCS-4) (1-Pentyl-3-[(4- 7104 I
methoxy)-benzoyl] indole).
JWH-018 (also known as AM678) (1-Pentyl-3-(1- 7118 I
naphthoyl)indole).
JWH-122 (1-Pentyl-3-(4-methyl-1-naphthoyl) 7122 I
indole).
UR-144 (1-Pentyl-1H-indol-3-yl)(2,2,3,3- 7144 I
tetramethylcyclopropyl)methanone.
JWH-073 (1-Butyl-3-(1-naphthoyl)indole)...... 7173 I
JWH-200 (1-[2-(4-Morpholinyl)ethyl]-3-(1- 7200 I
naphthoyl)indole).
AM2201 (1-(5-Fluoropentyl)-3-(1-naphthoyl) 7201 I
indole).
JWH-203 (1-Pentyl-3-(2-chlorophenylacetyl) 7203 I
indole).
NM2201, CBL2201 (Naphthalen-1-yl 1-(5- 7221 I
fluoropentyl)-1H-indole-3-carboxylate.
PB-22 (Quinolin-8-yl 1-pentyl-1H-indole-3- 7222 I
carboxylate).
5F-PB-22 (Quinolin-8-yl 1-(5-fluoropentyl)-1H- 7225 I
indole-3-carboxylate).
4-methyl-alpha-ethylaminopentiophenone (4- 7245 I
MEAP) 7245 I N 4-MEAP.
N-ethylhexedrone 7246 I N.................... 7246 I
Alpha-ethyltryptamine........................ 7249 I
Ibogaine..................................... 7260 I
2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan- 7286 I
1-one (methoxetamine).
CP-47,497 (5-(1,1-Dimethylheptyl)-2-[(1R,3S)- 7297 I
3-hydroxycyclohexyl-phenol).
CP-47,497 C8 Homologue (5-(1,1-Dimethyloctyl)- 7298 I
2-[(1R,3S)3-hydroxycyclohexyl-phenol).
Lysergic acid diethylamide................... 7315 I
2C-T-7 (2,5-Dimethoxy-4-(n)- 7348 I
propylthiophenethylamine.
Marihuana.................................... 7360 I
Tetrahydrocannabinols........................ 7370 I
Mescaline.................................... 7381 I
2C-T-2 (2-(4-Ethylthio-2,5-dimethoxyphenyl) 7385 I
ethanamine).
3,4,5-Trimethoxyamphetamine.................. 7390 I
4-Bromo-2,5-dimethoxyamphetamine............. 7391 I
4-Bromo-2,5-dimethoxyphenethylamine.......... 7392 I
4-Methyl-2,5-dimethoxyamphetamine............ 7395 I
2,5-Dimethoxyamphetamine..................... 7396 I
JWH-398 (1-Pentyl-3-(4-chloro-1-naphthoyl) 7398 I
indole).
2,5-Dimethoxy-4-ethylamphetamine............. 7399 I
3,4-Methylenedioxyamphetamine................ 7400 I
5-Methoxy-3,4-methylenedioxyamphetamine...... 7401 I
N-Hydroxy-3,4-methylenedioxyamphetamine...... 7402 I
3,4-Methylenedioxy-N-ethylamphetamine........ 7404 I
3,4-Methylenedioxymethamphetamine............ 7405 I
4-Methoxyamphetamine......................... 7411 I
5-Methoxy-N-N-dimethyltryptamine............. 7431 I
Alpha-methyltryptamine....................... 7432 I
Bufotenine................................... 7433 I
Diethyltryptamine............................ 7434 I
Dimethyltryptamine........................... 7435 I
Psilocybin................................... 7437 I
Psilocyn..................................... 7438 I
5-Methoxy-N,N-diisopropyltryptamine.......... 7439 I
4-chloro-alpha-pyrrolidinovalerophenone (4- 7443 I
chloro-aPV.
4[acute]-methyl-alpha-pyrrolidinohexiophenone 7446 I
(MPHP.
N-Ethyl-1-phenylcyclohexylamine.............. 7455 I
1-(1-Phenylcyclohexyl)pyrrolidine............ 7458 I
1-[1-(2-Thienyl)cyclohexyl]piperidine........ 7470 I
1-[1-(2-Thienyl)cyclohexyl]pyrrolidine....... 7473 I
N-Benzylpiperazine........................... 7493 I
4-MePPP (4-Methyl- 7498 I
alphapyrrolidinopropiophenone).
2C-D (2-(2,5-Dimethoxy-4-methylphenyl) 7508 I
ethanamine).
2C-E (2-(2,5-Dimethoxy-4-ethylphenyl) 7509 I
ethanamine).
2C-H 2-(2,5-Dimethoxyphenyl) ethanamine)..... 7517 I
2C-I 2-(4-iodo-2,5-dimethoxyphenyl) 7518 I
ethanamine).
2C-C 2-(4-Chloro-2,5-dimethoxyphenyl) 7519 I
ethanamine).
2C-N (2-(2,5-Dimethoxy-4-nitro-phenyl) 7521 I
ethanamine).
2C-P (2-(2,5-Dimethoxy-4-(n)-propylphenyl) 7524 I
ethanamine).
2C-T-4 (2-(4-Isopropylthio)-2,5- 7532 I
dimethoxyphenyl) ethanamine).
MDPV (3,4-Methylenedioxypyrovalerone)........ 7535 I
25B-NBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N- 7536 I
(2-methoxybenzyl) ethanamine).
25C-NBOMe (2-(4-chloro-2,5-dimethoxyphenyl)-N- 7537 I
(2-methoxybenzyl) ethanamine).
25I-NBOMe (2-(4-iodo-2,5-dimethoxyphenyl)-N- 7538 I
(2-methoxybenzyl) ethanamine).
Methylone (3,4-Methylenedioxy-N- 7540 I
methylcathinone).
Butylone..................................... 7541 I
Pentylone.................................... 7542 I
N-Ethypentylone, ephylone (1-(1,3-benzodioxol- 7543 I
5-yl)-2-(ethylamino)-pentan-1-one).
alpha-pyrrolidinohexanophenone (a-PHP)....... 7544 I
[[Page 54383]]
alpha-pyrrolidinopentiophenone ([alpha]-PVP). 7545 I
alpha-pyrrolidinobutiophenone ([alpha]-PBP).. 7546 I
Ethylone..................................... 7547 I
alpha-pyrrolidinoheptaphenone (PV8).......... 7548 I
Eutylone..................................... 7549 I
[alpha]-PiHP (4-methyl-1-phenyl-2-(pyrrolidin- 7551 I
1-yl)pentan-1-one).
AM-694 (1-(5-Fluoropentyl)-3-(2-iodobenzoyl) 7694 I
indole).
Acetyldihydrocodeine......................... 9051 I
Benzylmorphine............................... 9052 I
Codeine-N-oxide.............................. 9053 I
Desomorphine................................. 9055 I
Etorphine (except HCl)....................... 9056 I
Codeine methylbromide........................ 9070 I
Brorphine (1-(1-(1-(4- 9098 I
bromophenyl)ethyl)piperidin-4-4l)1,3-dihydro-
2H-benzo[d]imidazol-2-one).
Dihydromorphine.............................. 9145 I
Difenoxin.................................... 9168 I
Heroin....................................... 9200 I
Hydromorphinol............................... 9301 I
Morphine-N-oxide............................. 9307 I
Normorphine.................................. 9313 I
Thebacon..................................... 9315 I
U-47700 (3,4-dichloro-N-[2- 9547 I
(dimethylamino)cyclohexyl]-N-
methylbenzamide).
AH-7921 (3,4-dichloro-N-[(1- 9551 I
dimethylamino)cyclohexylmethyl]benzamide)).
MT-45 (1-cyclohexyl-4-(1,2- 9560 I
diphenylethyl)piperazine)).
Clonitazene.................................. 9612 I
Isotonotazene (N,N-diethyl-2-(2-(4 9614 I
isopropoxybenzyl)-5-nitro-1H-benzimidazol-1-
yl)ethan-1-amine).
Dipipanone................................... 9622 I
Etonitazene.................................. 9624 I
Ketobemidone................................. 9628 I
Trimeperidine................................ 9646 I
1-Methyl-4-phenyl-4-propionoxypiperidine..... 9661 I
1-(2-Phenylethyl)-4-phenyl-4- 9663 I
acetoxypiperidine.
2-methyl AP-237 (1-(2-methyl-4-(3-phenylprop- 9664 I
2-en-1-yl)piperazin-1-yl)butan-1-one.
Tilidine..................................... 9750 I
Butonitazene (2-(2-(4-butoxybenzyl)-5-nitro- 9751 I
1Hbenzimidazol-1-yl)-N,N-diethylethan-1-
amine).
lunitazene (N,N-diethyl-2-(2-(4-fluorobenzyl)- 9756 I
5-nitro1H-benzimidazol-1-yl)ethan-1-amine).
Metonitazene (N,N-diethyl-2-(2-(4- 9757 I
methoxybenzyl)-5-nitro-1Hbenzimidazol-1-
yl)ethan-1-amine.
N-pyrrolidino etonitazene; etonitazepyne (2- 9758 I
(4-ethoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-
yl)ethyl)-1Hbenzimidazole).
Protonitazene (N,N-diethyl-2-(5-nitro-2-(4- 9759 I
propoxybenzyl)-1H-benzimidazol-1-yl)ethan-1-
amine).
N-desethyl isotonitazene (N-ethyl-2-(2-(4- 9760 I
isopropoxylbenzyl)-5-nitro-1H-benzimidazol-1-
yl)ethan-1-amin).
N-piperidinyl etonitazene (2-(4-ethoxybenzyl)- 9761 I
5-nitro-1-(2-(piperidin-1-yl)ethyl-1H-
benzimidazole).
Metodesnitazene (N,N-diethyl-2-(2-(4- 9764 I
methoxybenzyl)-1H-benzimidazol-1-yl)ethan-1-
amine).
Etodesnitazene; etazene (2-(2-(4- 9765 I
ethoxybenzyl)-1Hbenzimidazol-1-yl)-N,N-
diethylethan-1-amine).
Acryl fentanyl (N-(1-phenethylpiperidin-4-yl)- 9811 I
N-phenylacrylamide).
Para-Fluorofentanyl.......................... 9812 I
3-Methylfentanyl............................. 9813 I
Alpha-methylfentanyl......................... 9814 I
Acetyl-alpha-methylfentanyl.................. 9815 I
N-(2-fluorophenyl)-N-(1-phenethylpiperidin-4- 9816 I
yl)propionamide.
Para-Methylfentanyl (N-(4-methylphenyl)-N-(1- 9817 I
phenethylpiperidin-4-yl)propionamide; also
known as 4-methylfentanyl).
para-Chlorofentanyl) N-(4-chlorophenyl)-N-(1- 9818 I
phenethylpiperidin-4-yl)propionamide).
4'-Methyl acetyl fentanyl (N-(1-(4- 9819 I
methylphenethyl)piperidin-4-yl)-N-
phenylacetamide).
ortho-Methyl methoxyacetyl fentanyl (2- 9820 I
methoxy-N-(2-methylphenyl)-N-(1-
phenethylpiperidin-4-yl)acetamide).
Acetyl Fentanyl (N-(1-phenethylpiperidin-4- 9821 I
yl)-N-phenylacetamide).
Butyryl Fentanyl............................. 9822 I
Para-fluorobutyryl fentanyl.................. 9823 I
4-Fluoroisobutyryl fentanyl (N-(4- 9824 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide).
2-methoxy-N-(1-phenethylpiperidin-4-yl)-N- 9825 I
phenylacetamide.
Para-chloroisobutyryl fentanyl............... 9826 I
Isobutyryl fentanyl.......................... 9827 I
ortho-Chlorofentanyl (N-(2-chlorophenyl)-N-(1- 9828 I
phenethylpiperidin-4-yl)propionamide).
Beta-hydroxyfentanyl......................... 9830 I
Beta-hydroxy-3-methylfentanyl................ 9831 I
Alpha-methylthiofentanyl..................... 9832 I
3-Methylthiofentanyl......................... 9833 I
Furanyl fentanyl (N-(1-phenethylpiperidin-4- 9834 I
yl)-N-phenylfuran-2-carboxamide).
Thiofentanyl................................. 9835 I
Beta-hydroxythiofentanyl..................... 9836 I
Para-methoxybutyryl fentanyl................. 9837 I
Ocfentanil................................... 9838 I
Thiofuranyl fentanyl (N-(1-phenethylpiperidin- 9839 I
4-yl)-Nphenylthiophene-2-carboxamide; also
known as 2-thiofuranyl fentanyl; thiophene
fentanyl).
Valeryl fentanyl............................. 9840 I
[[Page 54384]]
Phenyl fentanyl (N-(1-phenethylpiperidin-4- 9841 I
yl)-Nphenylbenzamide; also known as benzoyl
fentanyl).
beta'-Phenyl fentanyl (N-(1- 9842 I
phenethylpiperidin-4-yl)-N,3-
diphenylpropanamide; also known as [beta]'-
phenyl fentanyl; 3-phenylpropanoyl fentanyl).
N-(1-phenethylpiperidin-4-yl)-N- 9843 I
phenyltetrahydrofuran-2-carboxamide.
Crotonyl fentanyl ((E-N-(1-phenethylpiperidin- 9844 I
4-yl)-N-phenylbut-2-enamide).
Cyclopropyl Fentanyl......................... 9845 I
ortho-Fluorobutyryl fentanyl (N-(2- 9846 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)butyramide; also known as 2-fluorobutyryl
fentanyl).
Cyclopentyl fentanyl......................... 9847 I
ortho-Methyl acetylfentanyl (N-(2- 9848 I
methylphenyl)-N-(1-phenethylpiperidin-4-
yl)acetamide; also known as 2-methyl
acetylfentanyl).
Fentanyl related compounds as defined in 21 9850 I
CFR 1308.11(h).
Fentanyl carbamate (ethyl (1- 9851 I
phenethylpiperidin-4-yl)(phenyl)carbamate).
ortho-Fluoroacryl fentanyl (N-(2- 9852 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)acrylamide).
ortho-Fluoroisobutyryl fentanyl (N-(2- 9853 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide).
Para-Fluoro furanyl fentanyl (N-(4- 9854 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)furan-2-carboxamide).
2'-Fluoro ortho-fluorofentanyl (N-(1-(2- 9855 I
fluorophenethyl)piperidin-4-yl)-N-(2-
fluorophenyl)propionamide; also known as 2'-
fluoro 2-fluorofentanyl).
beta-Methyl fentanyl (N-phenyl-N-(1-(2- 9856 I
phenylpropyl)piperidin-4-yl)propionamide;
also known as [beta]-methyl fentanyl).
meta-Fluorofentanyl (N-(3-fluorophenyl)-N-(1- 9857 I
phenethylpiperidin-4-yl)propionamide).
meta-Fluoroisobutyryl fentanyl (N-(3- 9858 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)isobutyramide).
para-Methoxyfuranyl fentanyl (N-(4- 9859 I
methoxyphenyl)-N-(1-phenethylpiperidin-4-
yl)furan-2-carboxamide).
3-Furanyl fentanyl (N-(1-phenethylpiperidin-4- 9860 I
yl)-Nphenylfuran-3-carboxamide).
2',5'-Dimethoxyfentanyl (N-(1-(2,5- 9861 I
dimethoxyphenethyl)piperidin-4-yl)-
Nphenylpropionamide).
Isovaleryl fentanyl (3-methyl-N-(1- 9862 I
phenethylpiperidin-4-yl)-N-phenylbutanamide).
ortho-Fluorofuranyl fentanyl (N-(2- 9863 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)furan-2-carboxamide).
alpha'-Methyl butyryl fentanyl (2-methyl-N-(1- 9864 I
phenethylpiperidin-4-yl)-N-phenylbutanamide).
para-Methylcyclopropylfentanyl (N-(4- 9865 I
methylphenyl)-N-(1-phenethylpiperidin-4-
yl)cyclopropanecarboxamide).
beta-Methylacetyl fentanyl (N-phenyl-N-(1-(2- 9868 I
phenylpropyl)piperidin-4-yl)acetamide).
Tetrahydrothiofuranyl fentanyl (N-(1- 9869 I
phenethylpiperidin4-yl)-N-
phenyltetrahydrothiophene-2-carboxamide).
para-Fluoro valeryl fentanyl (N-(4- 9870 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)pentanamide).
meta-Fluorofuranyl fentanyl (N-(3- 9871 I
fluorophenyl)-N-(1-phenethylpiperidin-4-
yl)furan-2-carboxamide).
Zipeprol (1-methoxy-3[-4-(2-methoxy-2- 9873 I
phenylethyl)piperazin-1-yl]-1-phenylpropan-2-
ol).
Amphetamine.................................. 1100 II
Methamphetamine.............................. 1105 II
Lisdexamfetamine............................. 1205 II
Phenmetrazine................................ 1631 II
Methylphenidate.............................. 1724 II
Amobarbital.................................. 2125 II
Pentobarbital................................ 2270 II
Secobarbital................................. 2315 II
Glutethimide................................. 2550 II
1-Phenylcyclohexylamine...................... 7460 II
Phencyclidine................................ 7471 II
ANPP (4-Anilino-N-phenethyl-4-piperidine).... 8333 II
Norfentanyl (N-phenyl-N-(piperidin-4-yl) 8366 II
propionamide).
Phenylacetone................................ 8501 II
1-Piperidinocyclohexanecarbonitrile.......... 8603 II
Cocaine...................................... 9041 II
Codeine...................................... 9050 II
Etorphine HCl................................ 9059 II
Dihydrocodeine............................... 9120 II
Oxycodone.................................... 9143 II
Hydromorphone................................ 9150 II
Ecgonine..................................... 9180 II
Ethylmorphine................................ 9190 II
Hydrocodone.................................. 9193 II
Levomethorphan............................... 9210 II
Levorphanol.................................. 9220 II
Isomethadone................................. 9226 II
Meperidine................................... 9230 II
Meperidine intermediate-B.................... 9233 II
Oliceridine (N-[(3-methoxythiophen- 9245 II
2yl)methyl] ({2-[9r)-9-(pyridin-2-yl)-6-
oxaspiro[4.5] decan-9-yl] ethyl {time{time}
)amine fumarate).
Methadone.................................... 9250 II
Dextropropoxyphene, bulk (non-dosage forms).. 9273 II
Morphine..................................... 9300 II
Thebaine..................................... 9333 II
Oxymorphone.................................. 9652 II
Noroxymorphone............................... 9668 II
Thiafentanil................................. 9729 II
Alfentanil................................... 9737 II
Remifentanil................................. 9739 II
[[Page 54385]]
Sufentanil................................... 9740 II
Carfentanil.................................. 9743 II
Tapentadol................................... 9780 II
Bezitramide.................................. 9800 II
Fentanyl..................................... 9801 II
------------------------------------------------------------------------
The company plans to bulk manufacture the listed controlled
substances for forensic purposes, to research analytical reference
standards and as Active Pharmaceutical Ingredients for Phase 1 trials.
In reference to drug codes 7360 (Marihuana), and 7370
(Tetrahydrocannabinols), the company plans to bulk manufacture these
drugs as synthetic. No other activities for these drug codes are
authorized for this registration.
Justin Wood,
Acting Deputy Assistant Administrator.
[FR Doc. 2025-21183 Filed 11-25-25; 8:45 am]
BILLING CODE P
</pre></body>
</html>Indexed from Federal Register on November 26, 2025.
This is legal information, not legal advice. Laws vary by jurisdiction and change frequently. Always verify current law with official sources and consult a licensed attorney in your jurisdiction for advice on your specific situation.