Notice2025-08178
Government Owned Inventions Available for Licensing or Collaboration: Single Source-Detector Separation Approach To Calculate Tissue Oxygen Saturation
Primary source
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Published
May 9, 2025
Issuing agencies
Health and Human Services DepartmentNational Institutes of Health
Abstract
The National Institute of Child Health and Human Development (NICHD), an institute of the National Institutes of Health (NIH), Department of Health and Human Services (HHS), is giving notice of the licensing or collaboration opportunities for the inventions listed below, which are owned by an agency of the U.S. Government and are available for licensing and collaboration to achieve expeditious commercialization of results of federally-funded research and development.
Full Text
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<title>Federal Register, Volume 90 Issue 89 (Friday, May 9, 2025)</title>
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[Federal Register Volume 90, Number 89 (Friday, May 9, 2025)]
[Notices]
[Page 19725]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2025-08178]
[[Page 19725]]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government Owned Inventions Available for Licensing or
Collaboration: Single Source-Detector Separation Approach To Calculate
Tissue Oxygen Saturation
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
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SUMMARY: The National Institute of Child Health and Human Development
(NICHD), an institute of the National Institutes of Health (NIH),
Department of Health and Human Services (HHS), is giving notice of the
licensing or collaboration opportunities for the inventions listed
below, which are owned by an agency of the U.S. Government and are
available for licensing and collaboration to achieve expeditious
commercialization of results of federally-funded research and
development.
FOR FURTHER INFORMATION CONTACT: Inquiries related to these licensing
or collaboration opportunities should be directed to: Zarpheen Jinnah,
Ph.D., Technology Transfer Manager, NCI, Technology Transfer Center,
email: <a href="/cdn-cgi/l/email-protection#32485340425a57575c1c585b5c5c535a725c5b5a1c555d44"><span class="__cf_email__" data-cfemail="5d273c2f2d3538383373373433333c351d333435733a322b">[email protected]</span></a> or phone: 240-620-0586.
SUPPLEMENTARY INFORMATION: Tissue oxygen saturation (StO2) is an
important parameter to assess oxygen delivery and uptake. Hypoxia, a
term used to indicate inadequate StO2, is often seen in patients with
cardiac problems, respiratory infections or pulmonary diseases.
Prolonged hypoxia can damage vital organs such as the brain, lungs, and
heart and can be fatal. Currently available tissue oximeters to monitor
StO2 are expensive and cumbersome. NICHD has developed a novel method,
which uses a single source-detector separation to calculate StO2. With
this technique, a simple tissue oximeter can be made with just a LED
and a photodetector, which enables the development of a miniaturized
device. As a result, it can be used independently or implemented on
existing technologies to measure StO2 without any hardware
modifications. It can be applied in wearable devices, implantable
medicines or endoscopies to measure tissue oxygenation in different
tissues such as muscle, brain, spinal cord, internal organs, fetus and
placenta.
This Notice is in accordance with 35 U.S.C. 209 and 37 CFR part
404.
NIH Reference Number: E-037-2023-0.
Product Type: Device.
Therapeutic Area(s): Respiratory, Neurology or Cardiac.
Potential Commercial Applications:
<bullet> Miniaturized tissue oximeter for implantation or
endoscopy.
<bullet> Measure tissue oxygen saturation.
<bullet> Multilayer tissue oximeter.
Competitive Advantages:
<bullet> Simpler and more compact as it only requires a single
light source such as LED and a single photodetector such as a
photodetector to build a tissue oximeter.
<bullet> Multilayer measurement.
<bullet> Implementation with existing technologies without any
hardware modifications.
Publication: Nguyen, T., et al. Application of the Single Source--
Detector Separation Algorithm in Wearable Neuroimaging Devices: A Step
toward Miniaturized Biosensor for Hypoxia Detection. (PMID 38671806).
Patent Status: PCT Application PCT/US2023/085725 filed on December
22, 2023.
Development Stage: Clinical Phase I.
Dated: May 5, 2025.
Richard U. Rodriguez,
Associate Director, Technology Transfer Center, National Cancer
Institute.
[FR Doc. 2025-08178 Filed 5-8-25; 8:45 am]
BILLING CODE 4140-01-P
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