Notice2024-24983
Request for Public Comment on the Draft Skin Notation Profiles: Allyl Alcohol, Formamide, Formic Acid, Phenothiazine, and Picric Acid
Primary source
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Published
October 28, 2024
Issuing agencies
Health and Human Services DepartmentCenters for Disease Control and Prevention
Abstract
The National Institute for Occupational Safety and Health (NIOSH) in the Centers for Disease Control and Prevention (CDC), an Operating Division of the Department of Health and Human Services (HHS), requests public comment on the draft Skin Notation Profiles: Allyl alcohol, Formamide, Formic Acid, Phenothiazine, and Picric Acid.
Full Text
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<title>Federal Register, Volume 89 Issue 208 (Monday, October 28, 2024)</title>
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[Federal Register Volume 89, Number 208 (Monday, October 28, 2024)]
[Notices]
[Pages 85537-85538]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2024-24983]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[Docket Number CDC-2024-0085, NIOSH-153-F]
Request for Public Comment on the Draft Skin Notation Profiles:
Allyl Alcohol, Formamide, Formic Acid, Phenothiazine, and Picric Acid
AGENCY: Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Request for comment.
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SUMMARY: The National Institute for Occupational Safety and Health
(NIOSH) in the Centers for Disease Control and Prevention (CDC), an
Operating Division of the Department of Health and Human Services
(HHS), requests public comment on the draft Skin Notation Profiles:
Allyl alcohol, Formamide, Formic Acid, Phenothiazine, and Picric Acid.
DATES: Electronic or written comments must be received by December 27,
2024.
ADDRESSES: You may submit comments, identified by docket number CDC-
2024-0085 and docket number NIOSH-153-F, by either of the following
methods:
<bullet> Federal eRulemaking Portal: <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
Follow the instructions for submitting comments.
<bullet> Mail: National Institute for Occupational Safety and
Health, NIOSH Docket Office, 1090 Tusculum Avenue, MS C-34, Cincinnati,
OH 45226-1998.
Instructions: All information received in response to this notice
must include the agency name and docket number (CDC-2024-0085; NIOSH-
153-F). All relevant comments, including any personal information
provided, will be posted without change to <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
Do not submit comments by email. CDC does not accept comments by email.
For access to the docket to read background documents or comments
received, go to <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
FOR FURTHER INFORMATION CONTACT: Naomi Hudson, DrPH, National Institute
for Occupational Safety and Health, MS C-15, 1090 Tusculum Avenue,
Cincinnati, OH 45226-1998. Telephone: (513) 533-8388.
SUPPLEMENTARY INFORMATION: NIOSH is requesting public comment on draft
Skin Notation Profile documents for the chemicals Allyl alcohol,
Formamide, Formic Acid, Phenothiazine, and Picric Acid. To facilitate
the review of these documents, NIOSH requests responses to the
following specific questions for each draft Profile document:
1. Does this document clearly outline the systemic health hazards
associated with exposures of the skin to the chemical? If not, what
specific information is missing from the document?
2. If the SYS or SYS (FATAL) notations are assigned, are the
rationale and logic behind the assignment clear? If not assigned, is
the logic clear why it was not (e.g., insufficient data, no identified
health hazard)? If not clear, what clarification is suggested?
3. Does this document clearly outline the direct (localized) health
hazards associated with exposures of the skin to the chemical? If not,
what specific information is missing from the document?
4. If the DIR, DIR (IRR), or DIR (COR) notations are assigned, are
the rationale and logic behind the assignment clear? If not assigned,
is the logic clear why it was not (e.g., insufficient data, no
identified health hazard)? If not clear, what clarification is
suggested?
5. Does this document clearly outline the immune-mediated responses
(allergic response) associated with exposures of the skin to the
chemical? If not, what specific information is missing from the
document?
6. If the SEN notation is assigned, are the rationale and logic
behind the assignment clear? If not assigned, is the logic clear why it
was not assigned (e.g., insufficient data, no identified health
hazard)? If not clear, what clarification is suggested?
7. If the ID (SK) or SK were assigned, are the rationale and logic
outlined clearly within the document? If not clear, what clarification
is suggested?
8. Are the conclusions supported by the data? If not, what changes
are suggested?
9. Are the tables clear and appropriate? If not, what changes are
suggested?
10. Are you aware of any scientific data reported in governmental
publications, databases, peer-reviewed journals, or other sources that
should be considered within this document? Please include the full
reference citation for any additional scientific data to be considered.
11. There have been considerable improvements and advancements in
dermal absorption studies and modeling since the publication of NIOSH
Current Intelligence Bulletin 61: A Strategy for Assigning New NIOSH
Skin Notations [NIOSH 2017]. In response to expert external peer
reviewers' comments regarding the limitation of the skin to inhalation
dose (SI) ratio information, the SI ratio was removed from the
individual skin notation profile documents. Do you have any information
to support removing or including the SI ratio information in these
NIOSH documents?
The draft Skin Notation Profiles were developed to provide the
scientific rationale behind the development of skin notation
designations for the following chemicals:
<bullet> Allyl alcohol (CAS: 107-18-6)
<bullet> Formamide (CAS: 75-12-7)
<bullet> Formic acid (CAS: 64-18-6)
<bullet> Picric acid (CAS: 88-89-1)
<bullet> Phenothiazine (CAS: 92-84-2)
The Skin Notation Profiles provide a detailed summary of the health
hazards
[[Page 85538]]
of chemical exposure to the skin. The final publication, which will
address public comments, will be available on the NIOSH website and in
the NIOSH docket (153-F) and in <a href="http://Regulations.gov">Regulations.gov</a> (CDC-2024-0085).
Background: In 2009, NIOSH published Current Intelligence Bulletin
(CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH
2009]. The CIB presents a strategic framework that is a form of hazard
identification designed to do the following:
<bullet> Ensure that the assigned skin notations reflect the
contemporary state of scientific knowledge
<bullet> Provide transparency behind the assignment process
<bullet> Communicate the hazards of chemical exposures of the skin
<bullet> Meet the needs of health professionals, employers, and other
interested parties in protecting workers from chemical contact with the
skin.
This strategy involves the assignment of multiple skin notations
for distinguishing systemic (SYS), direct (DIR), and sensitizing (SEN)
effects caused by exposure of skin (SK) to chemicals. Chemicals that
are highly or extremely toxic and may be potentially lethal or life-
threatening following exposures of the skin are designated with the
systemic subnotation (FATAL). Potential irritants and corrosive
chemicals are indicated by the direct effects subnotations (IRR) and
(COR), respectively. The five draft Skin Notation Profiles available
for review were developed following the framework in NIOSH CIB 61.
Reference
NIOSH [2009]. Current Intelligence Bulletin 61: A strategy for
assigning new NIOSH skin notations. Cincinnati, OH: U.S. Department of
Health and Human Services, Centers for Disease Control and Prevention,
National Institute for Occupational Safety and Health, DHHS (NIOSH)
Publication 2009-147, <a href="https://www.cdc.gov/niosh/docs/2009-147/">https://www.cdc.gov/niosh/docs/2009-147/</a>.
Dated: October 23, 2024.
John J. Howard,
Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention, Department of Health and
Human Services.
[FR Doc. 2024-24983 Filed 10-25-24; 8:45 am]
BILLING CODE 4163-18-P
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