Notice2023-13251
Request for Public Comment on Two Draft Immediately Dangerous to Life or Health (IDLH) Values, for Hydrogen Bromide and Hydrogen Iodide
Primary source
Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.
Published
June 22, 2023
Issuing agencies
Health and Human Services DepartmentCenters for Disease Control and Prevention
Abstract
The National Institute for Occupational Safety and Health (NIOSH) in the Centers for Disease Control and Prevention (CDC), an Operating Division of the Department of Health and Human Services (HHS), requests public comment and technical review on two (2) draft Immediately Dangerous to Life or Health (IDLH) Value Profiles regarding the chemicals hydrogen bromide (CAS# 10035-10-6) and hydrogen iodide (CAS# 10034-85-2).
Full Text
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<title>Federal Register, Volume 88 Issue 119 (Thursday, June 22, 2023)</title>
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[Federal Register Volume 88, Number 119 (Thursday, June 22, 2023)]
[Notices]
[Pages 40826-40827]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2023-13251]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[Docket Number CDC-2019-0093, NIOSH-156-E]
Request for Public Comment on Two Draft Immediately Dangerous to
Life or Health (IDLH) Values, for Hydrogen Bromide and Hydrogen Iodide
AGENCY: Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Request for comment.
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SUMMARY: The National Institute for Occupational Safety and Health
(NIOSH) in the Centers for Disease Control and Prevention (CDC), an
Operating Division of the Department of Health and Human Services
(HHS), requests public comment and technical review on two (2) draft
Immediately Dangerous to Life or Health (IDLH) Value Profiles regarding
the chemicals hydrogen bromide (CAS# 10035-10-6) and hydrogen iodide
(CAS# 10034-85-2).
DATES: Electronic or written comments must be received by August 21,
2023.
ADDRESSES: You may submit comments, identified by docket number CDC-
2019-0093 and docket number NIOSH-156-E, by either of the following
methods:
<bullet> Federal eRulemaking Portal: <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
Follow the instructions for submitting comments.
<bullet> Mail: National Institute for Occupational Safety and
Health, NIOSH Docket Office, 1090 Tusculum Avenue, MS C-34, Cincinnati,
Ohio 45226-1998.
Instructions: All information received in response to this notice
must include the agency name and docket number (CDC-2019-0093; NIOSH-
156-E). All relevant comments, including any personal information
provided, will be posted without change to <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
Do not submit comments by email. CDC does not accept comments by email.
For access to the docket to read background documents or comments
received, go to <a href="https://www.regulations.gov">https://www.regulations.gov</a>.
FOR FURTHER INFORMATION CONTACT: R. Todd Niemeier, Ph.D., National
Institute for Occupational Safety and Health, MS-C15, 1090 Tusculum
Avenue, Cincinnati, OH 45226. Telephone: (513) 533-8166.
SUPPLEMENTARY INFORMATION: NIOSH is requesting public comment and
including technical review on two (2) draft IDLH Value Profiles. To
facilitate the review of these documents, NIOSH requests comment on the
following specific questions for each draft Profile:
1. Does this document clearly outline the health hazards associated
with acute (or short-term) exposures to the chemical? If not, what
specific information is missing from the document?
2. Are the rationale and logic behind the derivation of an IDLH
value for a specific chemical clearly explained? If not, what specific
information is needed to clarify the basis of the IDLH value?
3. Are the conclusions supported by the data?
4. Are the tables clear and appropriate?
5. Is the document organized appropriately? If not, what
improvements are needed?
6. Are you aware of any scientific data reported in government
publications, databases, peer-reviewed journals, or other sources that
should be included within this document? The draft IDLH Value Profiles
were developed to provide the scientific rationale behind derivation of
IDLH values for the following chemicals:
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Document No. Chemical CAS
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X-XX..................... Hydrogen Bromide............ (# 10035-10-6)
X-XX..................... Hydrogen Iodide............. (# 10034-85-2)
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Each IDLH Value Profile provides a detailed summary of the health
hazards of acute exposures to high airborne concentrations of the
chemical and the rationale for the ILDH value.
Background: In 2013, NIOSH published Current Intelligence Bulletin
(CIB) 66: Derivation of Immediately Dangerous to Life or Health (IDLH)
Values [<a href="http://www.cdc.gov/niosh/docs/2014-100/pdfs/2014-100.pdf">http://www.cdc.gov/niosh/docs/2014-100/pdfs/2014-100.pdf</a>]
[NIOSH 2013]. The information presented in this CIB represents the most
recent update of the scientific rationale and the methodology (hereby
referred to as the IDLH methodology) used to derive IDLH values. Since
the establishment of the IDLH values in the 1970s, NIOSH has continued
to review available scientific data to improve the protocol used to
derive acute exposure guidelines, in addition to the chemical specific
IDLH values.
IDLH values are based on health effects considerations determined
through a critical assessment of the toxicology and human health
effects data. This approach ensures that the IDLH values reflect an
airborne concentration of a substance that represents a high-risk
situation that may endanger workers' lives or health.
The primary steps applied in the establishment of an IDLH value
include the following:
1. Critical review of human and animal toxicity data to identify
potentially relevant studies and characterize the various lines of
evidence that can support the derivation of the IDLH value;
2. Determination of a chemical's mode of action or description of
how a chemical exerts its toxic effects;
3. Application of duration adjustments (time scaling) to determine
30-minute-equivalent exposure concentrations and the conduct of other
dosimetry adjustments, as needed;
4. Experimental or other data to establish a point of departure
(POD) such as lethal concentrations (e.g., LC50), lowest observed
adverse effect
[[Page 40827]]
level (LOAEL), or no observed adverse effect level (NOAEL);
5. Selection and application of an uncertainty factor (UF) for POD
or critical adverse effect concentration, identified from the available
studies to account for issues associated with interspecies and
intraspecies differences, severity of the observed effects, data
quality, or data insufficiencies; and
6. Development of the final recommendation for the IDLH value from
the various alternative lines of evidence, with use of a weight-of-
evidence approach to all the data.
Reference
NIOSH [2013]. Current intelligence bulletin 66: derivation of
immediately dangerous to life or health (IDLH) values. Cincinnati, OH:
U.S. Department of Health and Human Services, Centers for Disease
Control and Prevention, National Institute for Occupational Safety and
Health, DHHS (NIOSH) Publication 2014-100.
John J. Howard,
Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention.
[FR Doc. 2023-13251 Filed 6-21-23; 8:45 am]
BILLING CODE 4163-18-P
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