Notice2023-01416
Government-Owned Inventions; Availability for Licensing
Primary source
Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.
Published
January 25, 2023
Issuing agencies
Health and Human Services DepartmentNational Institutes of Health
Abstract
The invention listed below is owned by an agency of the U.S. Government and is available for licensing to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing.
Full Text
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<title>Federal Register, Volume 88 Issue 16 (Wednesday, January 25, 2023)</title>
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[Federal Register Volume 88, Number 16 (Wednesday, January 25, 2023)]
[Notices]
[Page 4833]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2023-01416]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
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SUMMARY: The invention listed below is owned by an agency of the U.S.
Government and is available for licensing to achieve expeditious
commercialization of results of federally-funded research and
development. Foreign patent applications are filed on selected
inventions to extend market coverage for companies and may also be
available for licensing.
FOR FURTHER INFORMATION CONTACT: Amy F. Petrik, Ph.D., 240-627-3721;
<a href="/cdn-cgi/l/email-protection#eb8a8692c59b8e9f998280ab858283c58c849d"><span class="__cf_email__" data-cfemail="4425293d6a342130362d2f042a2d2c6a232b32">[email protected]</span></a>. Licensing information and copies of the U.S. patent
application listed below may be obtained by communicating with the
indicated licensing contact at the Technology Transfer and Intellectual
Property Office, National Institute of Allergy and Infectious Diseases,
5601 Fishers Lane, Rockville, MD 20852; tel. 301-496-2644. A signed
Confidential Disclosure Agreement will be required to receive copies of
unpublished patent applications.
SUPPLEMENTARY INFORMATION: Technology description follows:
Antibodies With Potent and Broad Neutralizing Activity Against
Antigenically Diverse and Highly Transmissible SARS-CoV-2 Variants
Description of Technology: Emergence of highly transmissible SARS-
CoV-2 variants of concern that are resistant to current therapeutic
antibodies highlights the need for continuing discovery of broadly
reactive antibodies.
Scientists at the Vaccine Research Center of the National Institute
of Allergy and Infectious Diseases have identified multiple antibodies
that ultra-potently neutralize SARS-CoV-2, including the highly
transmissible BA.4, BA.5, BQ.1.1 and XBB subvariants of Omicron, as
shown in a pseudovirus neutralization assay. These antibodies target
several epitopes in the receptor binding domain of the spike protein
that are not impacted by spike mutations that knockout binding to other
therapeutic antibodies, including, K417N, N439K, N440K, K444T, V445P,
G446S, L452R, Y453F, N460K, S477N, E484A/K, F486S/V and Q498R. Several
of the antibodies are able to simultaneously bind to the spike protein
and are compatible for use in combination therapies.
This technology is available for licensing for commercial
development in accordance with 35 U.S.C. 209 and 37 CFR part 404.
Potential Commercial Applications:
<bullet> Treatment of SARS-CoV-2 infection
Competitive Advantages:
<bullet> Ultra-potent neutralization of currently identified SARS-CoV-2
variants including Omicron subvariants BQ.1.1 and XBB
<bullet> Mechanism of Action--Some antibodies directly bind to and
block ACE2 receptor binding to the SARS-CoV-2 spike protein
Development Stage: Preclinical Research.
Inventors: John Misasi (VRC, NIAID), Lingshu Wang (VRC, NIAID),
John Mascola (VRC, NIAID), Daniel Douek (VRC, NIAID), Nancy Sullivan
(VRC, NIAID), Richard Alan Koup (VRC, NIAID), Man Chen, (VRC, NIAID),
Wei Shi (VRC, NIAID), Yi Zhang (VRC, NIAID), Eun Sung Yang (VRC,
NIAID), Nicole Doria-Rose (VRC, NIAID), Chaim Schramm (VRC, NIAID),
Kevina Maria Nabireka Birungi-Huff (VRC, NIAID), Sabrina Bush (VRC,
NIAID), Maryam Musayev (VRC, NIAID).
Publications: None.
Intellectual Property: HHS Reference Number E-024-2023 includes
U.S. Provisional Patent Application Number 63/433,719 filed December
19, 2022.
Licensing Contact: To license this technology, please contact Amy
F. Petrik, Ph.D., 240-627-3721; <a href="/cdn-cgi/l/email-protection#adccc0d483ddc8d9dfc4c6edc3c4c583cac2db"><span class="__cf_email__" data-cfemail="31505c481f41544543585a715f58591f565e47">[email protected]</span></a>.
Dated: January 19, 2023.
Surekha Vathyam,
Deputy Director, Technology Transfer and Intellectual Property Office,
National Institute of Allergy and Infectious Diseases.
[FR Doc. 2023-01416 Filed 1-24-23; 8:45 am]
BILLING CODE 4140-01-P
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