Notice2022-25170
Request for Nominations for the Science Advisory Board Inorganic Arsenic Review Panel
Primary source
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Published
November 22, 2022
Issuing agencies
Environmental Protection Agency
Abstract
The Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff Office requests public nominations of scientific experts to form a Panel to review the draft EPA Integrated Risk Information System (IRIS) Toxicological Review of Inorganic Arsenic. Based on the publicly available systematic review protocol, EPA's draft assessment includes a summary of the chemical properties and pharmacokinetics; hazard identification analysis for diseases of the circulatory system, pregnancy and birth outcomes, diabetes, and neurodevelopmental effects; and dose-response analysis characterizing the quantitative relationship for the noncancer outcomes listed above as well as for bladder cancer and lung cancer. These quantitative relationships are then used to derive cancer and non-cancer toxicity values (e.g., oral slope factor, reference dose). The SAB Inorganic Arsenic Review Panel will consider whether the conclusions found in the EPA's draft assessment are clearly presented and scientifically supported.
Full Text
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<title>Federal Register, Volume 87 Issue 224 (Tuesday, November 22, 2022)</title>
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[Federal Register Volume 87, Number 224 (Tuesday, November 22, 2022)]
[Notices]
[Pages 71328-71329]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2022-25170]
[[Page 71328]]
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ENVIRONMENTAL PROTECTION AGENCY
[FRL-10398-01-OA]
Request for Nominations for the Science Advisory Board Inorganic
Arsenic Review Panel
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice.
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SUMMARY: The Environmental Protection Agency (EPA) Science Advisory
Board (SAB) Staff Office requests public nominations of scientific
experts to form a Panel to review the draft EPA Integrated Risk
Information System (IRIS) Toxicological Review of Inorganic Arsenic.
Based on the publicly available systematic review protocol, EPA's draft
assessment includes a summary of the chemical properties and
pharmacokinetics; hazard identification analysis for diseases of the
circulatory system, pregnancy and birth outcomes, diabetes, and
neurodevelopmental effects; and dose-response analysis characterizing
the quantitative relationship for the noncancer outcomes listed above
as well as for bladder cancer and lung cancer. These quantitative
relationships are then used to derive cancer and non-cancer toxicity
values (e.g., oral slope factor, reference dose). The SAB Inorganic
Arsenic Review Panel will consider whether the conclusions found in the
EPA's draft assessment are clearly presented and scientifically
supported.
DATES: Nominations should be submitted by December 9, 2022 per the
instructions below.
FOR FURTHER INFORMATION CONTACT: Any member of the public wishing
further information regarding this Notice and Request for Nominations
may contact Dr. Diana Wong, Designated Federal Officer (DFO), EPA
Science Advisory Board Staff Office by telephone/voice mail (202) 564-
2049, or email at <a href="/cdn-cgi/l/email-protection#f0879f9e97de9499919e91dd9db0958091de979f86"><span class="__cf_email__" data-cfemail="f780989990d9939e969996da9ab7928796d9909881">[email protected]</span></a>. General information concerning
the EPA SAB can be found at the EPA SAB website at <a href="https://sab.epa.gov">https://sab.epa.gov</a>.
SUPPLEMENTARY INFORMATION:
Background: The SAB (42 U.S.C. 4365) is a chartered Federal
Advisory Committee that provides independent scientific and technical
peer review, advice, and recommendations to the EPA Administrator on
the technical basis for EPA actions. As a Federal Advisory Committee,
the SAB conducts business in accordance with the Federal Advisory
Committee Act (FACA) (5 U.S.C. app. 2) and related regulations. The SAB
Staff Office is forming an expert panel, the SAB Inorganic Arsenic
Review Panel, under the auspices of the Chartered SAB. The SAB
Inorganic Arsenic Review Panel will provide advice through the
chartered SAB. The SAB and the Inorganic Arsenic Review Panel will
comply with the provisions of FACA and all appropriate SAB Staff Office
procedural policies.
The SAB Inorganic Arsenic Review Panel will conduct a review of the
draft EPA IRIS Toxicological Review of Inorganic Arsenic. Based on the
publicly available systematic review protocol, EPA's draft assessment
includes a summary of the chemical properties and pharmacokinetics;
hazard identification analysis for diseases of the circulatory system,
pregnancy and birth outcomes, diabetes, and neurodevelopmental effects;
and dose-response analysis characterizing the quantitative relationship
for the noncancer outcomes listed above as well as for bladder cancer
and lung cancer. The SAB Inorganic Arsenic Review Panel will consider
whether the conclusions found in the EPA's draft assessment are clearly
presented and scientifically supported. The Panel will also be asked to
provide recommendations on how the assessment may be strengthened.
Request for Nominations: The SAB Staff Office is seeking
nominations of nationally and internationally recognized scientists
with demonstrated expertise and experience in the following
disciplines: Epidemiology, including specific expertise in
carcinogenesis, cardiovascular disease, reproductive and developmental
toxicity, neurodevelopmental outcomes, and diabetes; systematic review;
physiologically-based pharmacokinetic (PBPK) modeling; risk assessment;
epidemiological dose-response analysis; and Bayesian statistics.
Process and Deadline for Submitting Nominations: Any interested
person or organization may nominate qualified individuals in the areas
of expertise described above for possible service on the SAB Panel.
Individuals may self-nominate. Nominations should be submitted in
electronic format (preferred) using the online nomination form on the
SAB website at <a href="https://sab.epa.gov">https://sab.epa.gov</a> (see the ``Public Input on
Membership'' list under ``Committees, Panels, and Membership''). To be
considered, nominations should include the information requested below.
EPA values and welcomes diversity. All qualified candidates are
encouraged to apply regardless of sex, race, disability or ethnicity.
Nominations should be submitted in time to arrive no later than
December 9, 2022. The following information should be provided on the
nomination form: contact information for the person making the
nomination; contact information for the nominee; and the disciplinary
and specific areas of expertise of the nominee. Nominees will be
contacted by the SAB Staff Office and will be asked to provide a recent
curriculum vitae and a narrative biographical summary that includes
current position; educational background; research activities; sources
of research funding for the last two years; and recent service on other
national advisory committees or national professional organizations.
Persons having questions about the nomination procedures, or who are
unable to submit nominations through the SAB website, should contact
the DFO at the contact information noted above. The names and
biosketches of qualified nominees identified by respondents to this
Federal Register notice, and additional experts identified by the SAB
Staff Office, will be posted in a List of Candidates for the Panel on
the SAB website at <a href="https://sab.epa.gov">https://sab.epa.gov</a>. Public comments on the List of
Candidates will be accepted for 21 days. The public will be requested
to provide relevant information or other documentation on nominees that
the SAB Staff Office should consider in evaluating candidates.
For the EPA SAB Staff Office, a balanced review panel includes
candidates who possess the necessary domains of knowledge, the relevant
scientific perspectives (which, among other factors, can be influenced
by work history and affiliation), and the collective breadth of
experience to adequately address the charge. In forming the expert
panel, the SAB Staff Office will consider public comments on the Lists
of Candidates, information provided by the candidates themselves, and
background information independently gathered by the SAB Staff Office.
Selection criteria to be used for panel membership include: (a)
scientific and/or technical expertise, knowledge, and experience
(primary factors); (b) availability and willingness to serve; (c)
absence of financial conflicts of interest; (d) absence of an
appearance of a loss of impartiality; (e) skills working in committees,
subcommittees and advisory panels; and (f) for the panel as a whole,
diversity of expertise and scientific points of view.
The SAB Staff Office's evaluation of an absence of financial
conflicts of interest will include a review of the ``Confidential
Financial Disclosure Form for Environmental Protection Agency Special
Government Employees'' (EPA Form 3110-48). This
[[Page 71329]]
confidential form is required and allows government officials to
determine whether there is a statutory conflict between a person's
public responsibilities (which include membership on an EPA federal
advisory committee) and private interests and activities, or the
appearance of a loss of impartiality, as defined by federal regulation.
The form may be viewed and downloaded through the ``Ethics Requirements
for Advisors'' link on the SAB website at <a href="https://sab.epa.gov">https://sab.epa.gov</a>. This
form should not be submitted as part of a nomination.
V. Khanna Johnston,
Deputy Director, Science Advisory Board Staff Office.
[FR Doc. 2022-25170 Filed 11-21-22; 8:45 am]
BILLING CODE 6560-50-P
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