Notice2022-20787
Interagency Coordinating Committee on the Validation of Alternative Methods Biennial Progress Report: 2020-2021; Availability of Report
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Published
September 26, 2022
Issuing agencies
Health and Human Services DepartmentNational Institutes of Health
Abstract
The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) announces availability of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Biennial Progress Report: 2020-2021. This report, prepared in accordance with requirements of the ICCVAM Authorization Act of 2000, describes activities and accomplishments from January 2020 through December 2021.
Full Text
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<title>Federal Register, Volume 87 Issue 185 (Monday, September 26, 2022)</title>
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[Federal Register Volume 87, Number 185 (Monday, September 26, 2022)]
[Notices]
[Pages 58363-58364]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2022-20787]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Interagency Coordinating Committee on the Validation of
Alternative Methods Biennial Progress Report: 2020-2021; Availability
of Report
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
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SUMMARY: The National Toxicology Program (NTP) Interagency Center for
the Evaluation of Alternative Toxicological Methods (NICEATM) announces
availability of the Interagency Coordinating Committee on the
Validation of Alternative Methods (ICCVAM) Biennial Progress Report:
2020-2021. This report, prepared in accordance with requirements of the
ICCVAM Authorization Act of 2000, describes activities and
accomplishments from January 2020 through December 2021.
ADDRESSES: The report is available at <a href="https://ntp.niehs.nih.gov/go/2021iccvamreport">https://ntp.niehs.nih.gov/go/2021iccvamreport</a>.
FOR FURTHER INFORMATION CONTACT: Dr. Nicole Kleinstreuer, Acting
Director, NICEATM, Division of Translational Toxicology, NIEHS, P.O.
Box 12233, K2-17, Research Triangle Park, NC 27709. Phone: 984-287-
3150, Email: <a href="/cdn-cgi/l/email-protection#7b15121814171e5510171e1215080f091e0e1e093b151213551c140d"><span class="__cf_email__" data-cfemail="eb85828884878ec580878e8285989f998e9e8e99ab858283c58c849d">[email protected]</span></a>. Hand Deliver/Courier address:
530 Davis Drive, Room K2032, Morrisville, NC 27560.
SUPPLEMENTARY INFORMATION:
Background
The ICCVAM Authorization Act of 2000 established ICCVAM as a
permanent interagency committee of the National Institute of
Environmental Health Sciences (NIEHS) under NICEATM. ICCVAM's mission
is to facilitate development, validation, and regulatory acceptance of
new and revised regulatory test methods that reduce, refine, or replace
the use of animals in testing while maintaining and promoting
scientific quality and the protection of human health, animal health,
and the environment.
A provision of the ICCVAM Authorization Act states that ICCVAM
shall prepare ``reports to be made available to the public on its
progress under this Act.'' The eleventh progress report describing
ICCVAM activities and accomplishments from January 2020 through
December 2021 is now available.
Summary of Report Contents: Key ICCVAM, ICCVAM agency, and NICEATM
accomplishments summarized in the report include:
<bullet> Publication by the Organisation for Economic Co-operation
and Development of Guideline 497, Defined Approaches on Skin
Sensitisation, the first internationally harmonized guideline to
describe a non-animal approach that can be used to replace an animal
test to identify skin sensitizers. Guideline 497 was drafted and
sponsored by ICCVAM agency scientists and international partners.
<bullet> Recommendations in March 2021 by the ICCVAM Metrics
Workgroup on federal agency progress in promoting alternative
toxicological methods. The workgroup recommended each agency develop
its own metrics relevant and practical to their own situation.
<bullet> Establishment of the Workgroup on Microphysiological
Systems for COVID Research, an international collaborative workgroup to
coordinate use of microphysiological systems to reduce animal use in
COVID-19 studies and future emerging infectious diseases. A key
accomplishment of the workgroup was the establishment of a COVID-19
disease portal in an existing microphysiological systems database.
<bullet> Further development of the Collaborative Acute Toxicity
Modeling Suite (CATMoS), an online resource for in silico screening of
organic chemicals for acute oral toxicity. During 2020 and 2021, the
utility of CATMoS for predicting acute oral toxicity in research and
regulatory contexts was explored in projects conducted by ICCVAM
agencies, including the U.S. Department of Defense and the U.S.
Environmental Protection Agency.
<bullet> Updates of the Integrated Chemical Environment Search tool
during 2020 and 2021 to enable search results to be sent to query other
data resources. Updates also allowed users to explore similarities
among chemicals, find information on chemical use categories, search
for structurally similar chemicals, and view and interact with
concentration-response curves from curated high-throughput screening
data.
Availability of Report: The report is available at <a href="https://ntp.niehs.nih.gov/go/2021iccvamreport">https://ntp.niehs.nih.gov/go/2021iccvamreport</a>. Links to this report and all
past ICCVAM annual and biennial reports are available at <a href="http://ntp.niehs.nih.gov/go/iccvam">http://ntp.niehs.nih.gov/go/iccvam</a>-bien.
Background Information on ICCVAM and NICEATM: ICCVAM is an
interagency committee composed of representatives from 17 federal
regulatory and research agencies that require, use, generate, or
disseminate toxicological and safety testing information. ICCVAM
conducts technical evaluations of new, revised, and alternative safety
testing methods and integrated testing strategies with regulatory
applicability. ICCVAM also promotes the scientific validation and
regulatory acceptance of testing methods that more accurately assess
the safety and hazards of chemicals and products and replace, reduce,
or refine animal use.
The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes
ICCVAM as a permanent interagency committee of NIEHS and provides the
authority for ICCVAM involvement in activities relevant to the
development of
[[Page 58364]]
alternative test methods. Additional information about ICCVAM can be
found at <a href="http://ntp.niehs.nih.gov/go/iccvam">http://ntp.niehs.nih.gov/go/iccvam</a>.
NICEATM administers ICCVAM, provides scientific and operational
support for ICCVAM-related activities, and conducts and publishes
analyses and evaluations of data from new, revised, and alternative
testing approaches. NICEATM and ICCVAM work collaboratively to evaluate
new and improved testing approaches applicable to the needs of U.S.
federal agencies. NICEATM and ICCVAM welcome the public nomination of
new, revised, and alternative testing approaches for validation studies
and technical evaluations. Additional information about NICEATM can be
found at <a href="http://ntp.niehs.nih.gov/go/niceatm">http://ntp.niehs.nih.gov/go/niceatm</a>.
Dated: September 21, 2022.
Brian R. Berridge,
Associate Director, National Toxicology Program.
[FR Doc. 2022-20787 Filed 9-23-22; 8:45 am]
BILLING CODE 4140-01-P
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