Notice2021-27692
Interagency Coordinating Committee on the Validation of Alternative Methods Communities of Practice Webinar on New Approach Methodologies To Assess (Developmental) Neurotoxicity; Notice of Public Webinar; Registration Information
Primary source
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Published
December 22, 2021
Issuing agencies
Health and Human Services DepartmentNational Institutes of Health
Abstract
The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) announces a public webinar "New Approach Methodologies to Assess (Developmental) Neurotoxicity." The webinar is organized on behalf of ICCVAM by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). Interested persons may participate via the web meeting platform. Time will be allotted for questions from the audience. Information about the webinar and registration are available at https://ntp.niehs.nih.gov/go/commprac-2022.
Full Text
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<title>Federal Register, Volume 86 Issue 243 (Wednesday, December 22, 2021)</title>
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[Federal Register Volume 86, Number 243 (Wednesday, December 22, 2021)]
[Notices]
[Pages 72609-72610]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2021-27692]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Interagency Coordinating Committee on the Validation of
Alternative Methods Communities of Practice Webinar on New Approach
Methodologies To Assess (Developmental) Neurotoxicity; Notice of Public
Webinar; Registration Information
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
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SUMMARY: The Interagency Coordinating Committee on the Validation of
Alternative Methods (ICCVAM) announces a public webinar ``New Approach
Methodologies to Assess (Developmental) Neurotoxicity.'' The webinar is
organized on behalf of ICCVAM by the National Toxicology Program
Interagency Center for the Evaluation of Alternative Toxicological
Methods (NICEATM). Interested persons may participate via the web
meeting platform. Time will be allotted for questions from the
audience. Information about the webinar and registration are available
at <a href="https://ntp.niehs.nih.gov/go/commprac-2022">https://ntp.niehs.nih.gov/go/commprac-2022</a>.
DATES:
Webinar: January 25, 2022, 10:00 a.m. to approximately 11:30 a.m.
EST.
Registration for Webinar: January 4, 2022, until 11:30 a.m. EST
January 25, 2022.
Registration to view the webinar is required.
ADDRESSES: Webinar web page: <a href="https://ntp.niehs.nih.gov/go/commprac-2022">https://ntp.niehs.nih.gov/go/commprac-2022</a>.
FOR FURTHER INFORMATION CONTACT: Dr. Nicole Kleinstreuer, Acting
Director, NICEATM, email: <a href="/cdn-cgi/l/email-protection#89e7e0eae6e5eca7e2e5ece0e7fafdfbecfcecfbc9e7e0e1a7eee6ff"><span class="__cf_email__" data-cfemail="2846414b47444d0643444d41465b5c5a4d5d4d5a68464140064f475e">[email protected]</span></a>, telephone: (984)
287-3150.
SUPPLEMENTARY INFORMATION:
Background: ICCVAM promotes the development and validation of
toxicity testing methods that protect human health and the environment
while replacing, reducing, or refining animal use. ICCVAM also provides
guidance to test method developers and facilitates collaborations that
promote the development of new test methods. To address these goals,
ICCVAM will hold a Communities of Practice webinar on ``New Approach
Methodologies to Assess (Developmental) Neurotoxicity.''
The nervous system has unique characteristics and can have
different sensitivity to toxic substances compared to other organ
systems. Effects of chemicals on the nervous system can be affected by
concurrent exposures to other substances. During early life stages,
exposure to neuroactive drugs and environmental toxins can interact
and/or interfere with developmental processes of the brain, which can
in turn result in structural and/or functional alterations. Traditional
(developmental) neurotoxicity tests use mammals, but the high cost and
low throughput of these tests make them impractical to use for all
chemicals of potential concern. In addition, it is challenging to
correlate the interpretation of animal data to complex human
neurological effects. Therefore, interest is increasing in exploring
human cell-based assays, computational systems, and other alternatives
to traditional animal tests that can be used to predict chemical
effects on the developing and adult nervous system.
``New approach methodologies'' (NAMs) refers to any non-animal
technology or approach, or combination of these, that can be used to
provide information on chemical hazard and risk assessment. This
webinar will discuss NAMs that are being considered or developed for
assessing potential effects of chemicals on the nervous system. Key
insights and ongoing activities will be described in two presentations
featuring speakers from U.S. federal research and regulatory agencies.
The preliminary agenda and additional information about presentations
will be posted at <a href="https://ntp.niehs.nih.gov/go/commprac-2022">https://ntp.niehs.nih.gov/go/commprac-2022</a> as
available.
Webinar and Registration: This webinar is open to the public with
time scheduled for questions by participants following each
presentation. Registration for the webinar is required and will be open
from January 4, 2022, through 11:30 a.m. EST on January 25, 2022.
Registration is available at <a href="https://ntp.niehs.nih.gov/go/commprac-2022">https://ntp.niehs.nih.gov/go/commprac-2022</a>. Interested individuals are encouraged to visit this web page to
stay abreast of the most current webinar information. Registrants will
receive instructions on how to access and participate in the webinar in
the email confirming their registration.
Background Information on ICCVAM and NICEATM: ICCVAM is an
interagency committee composed of representatives from 17 federal
regulatory and research agencies that require, use, generate, or
disseminate
[[Page 72610]]
toxicological and safety testing information. ICCVAM conducts technical
evaluations of new, revised, and alternative safety testing methods and
integrated testing strategies with regulatory applicability. ICCVAM
also promotes the scientific validation and regulatory acceptance of
testing methods that more accurately assess the safety and hazards of
chemicals and products and replace, reduce, or refine animal use.
The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) establishes
ICCVAM as a permanent interagency committee of the National Institute
of Environmental Health Sciences and provides the authority for ICCVAM
involvement in activities relevant to the development of alternative
test methods. Additional information about ICCVAM can be found at
<a href="https://ntp.niehs.nih.gov/go/iccvam">https://ntp.niehs.nih.gov/go/iccvam</a>.
NICEATM administers ICCVAM, provides support for ICCVAM-related
activities, and conducts and publishes analyses and evaluations of data
from new, revised, and alternative testing approaches. NICEATM and
ICCVAM work collaboratively to evaluate new and improved testing
approaches applicable to the needs of U.S. federal agencies. NICEATM
and ICCVAM welcome the public nomination of new, revised, and
alternative test methods and strategies for validation studies and
technical evaluations. Additional information about NICEATM can be
found at <a href="https://ntp.niehs.nih.gov/go/niceatm">https://ntp.niehs.nih.gov/go/niceatm</a>.
Dated: December 16, 2021.
Brian R. Berridge,
Associate Director, National Toxicology Program.
[FR Doc. 2021-27692 Filed 12-21-21; 8:45 am]
BILLING CODE 4140-01-P
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