Notice2021-11626
Final Current Intelligence Bulletin 70: Health Effects of Occupational Exposure to Silver Nanomaterials
Primary source
Metadata and text below are from the Federal Register, a public-domain U.S. government work. Always verify the official published version before relying on it for any legal matter.
Published
June 3, 2021
Issuing agencies
Health and Human Services DepartmentCenters for Disease Control and Prevention
Abstract
NIOSH announces the availability of the final Current Intelligence Bulletin (CIB) 70: Health Effects of Occupational Exposure to Silver Nanomaterials.
Full Text
<html>
<head>
<title>Federal Register, Volume 86 Issue 105 (Thursday, June 3, 2021)</title>
</head>
<body><pre>
[Federal Register Volume 86, Number 105 (Thursday, June 3, 2021)]
[Notices]
[Pages 29787-29788]
From the Federal Register Online via the Government Publishing Office [<a href="http://www.gpo.gov">www.gpo.gov</a>]
[FR Doc No: 2021-11626]
=======================================================================
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
Centers for Disease Control and Prevention
[CDC-2016-0001; Docket Number NIOSH-260-A]
Final Current Intelligence Bulletin 70: Health Effects of
Occupational Exposure to Silver Nanomaterials
AGENCY: National Institute for Occupational Safety and Health (NIOSH)
of the Centers for Disease Control and Prevention (CDC), Department of
Health and Human Services (HHS).
ACTION: Notice of availability.
-----------------------------------------------------------------------
SUMMARY: NIOSH announces the availability of the final Current
Intelligence Bulletin (CIB) 70: Health Effects of Occupational Exposure
to Silver Nanomaterials.
DATES: The final document was published on May 26, 2021 on the CDC
website.
ADDRESSES: The document may be obtained at the following link: <a href="https://www.cdc.gov/niosh/docs/2021-112/">https://www.cdc.gov/niosh/docs/2021-112/</a>.
FOR FURTHER INFORMATION CONTACT: Jay Vietas, (<a href="/cdn-cgi/l/email-protection#4c263a2529382d3f0c2f282f622b233a"><span class="__cf_email__" data-cfemail="87edf1eee2f3e6f4c7e4e3e4a9e0e8f1">[email protected]</span></a>),
National Institute for Occupational Safety and Health, Centers for
Disease Control and Prevention, Mailstop C-14, 1090 Tusculum Avenue,
phone (513) 533-8150 (not a toll free number).
SUPPLEMENTARY INFORMATION: NIOSH first published a request on December
19, 2012, for information on occupational exposure to silver
nanomaterials, possible health effects in workers exposed to silver
nanomaterials, toxicology studies of silver nanomaterials in animals
and cellular systems, and information on exposure measurement methods,
control measures, and other data in the Federal Register [77 FR 75169].
In January 2016, NIOSH released a draft of the CIB for external review
and published notices of a public meeting and comment period on January
21, 2016 in the Federal Register [81 FR 342], and February 10, 2016 [81
FR 7124]. A public meeting was held on March 23, 2016, and members of
the public, stakeholders, and scientific peer reviewers were given the
opportunity to provide comments by April 22, 2016. In response to those
comments, NIOSH performed a second systematic review of the scientific
literature through January 2017 to include additional publications on
the occupational exposure to silver nanomaterials and possible health
effects in humans and toxicology
[[Page 29788]]
studies of silver nanomaterials in animals and cellular systems. Based
on review of the scientific literature, NIOSH revised the draft CIB and
developed a recommended exposure limit (REL) for silver nanomaterials.
The revised draft CIB was released for public review with a Federal
Register notice on September 18, 2018 [83 FR 47174]. The notice
included a request for comments from peer reviewers and the public and
provided information regarding a second public meeting that was held on
October 30, 2018. The purpose of the public review was to obtain
comments on whether the NIOSH draft document (1) adequately and clearly
described the scientific literature on the potential adverse health
effects of silver nanomaterials, and (2) demonstrated that the NIOSH
recommendations on occupational exposure to silver nanomaterials are
consistent with current scientific knowledge. Public, stakeholder, and
scientific peer reviewers were given the opportunity to submit comments
to the docket by November 30, 2018.
NIOSH carefully considered the comments received on the revised
draft document. Reviewers provided comments on the NIOSH assessment of
the potential adverse health effects of occupational exposure to silver
nanomaterials, on the data and methods NIOSH used to develop a
recommended exposure limit for silver nanomaterials, on the NIOSH
recommended methods for assessing and controlling exposures to silver
nanomaterials in the workplace, and on the identified data gaps and
future research needs. In developing the final document, NIOSH
performed an additional systematic literature search in April 2019 to
determine if any subsequent studies in animals or humans had been
published that pertained to the quantitative risk assessment and the
derivation of a REL for silver nanomaterials. No additional studies
were found that impacted those topics. NIOSH responded to the public,
stakeholder, and peer review comments received and developed the final
document consistent with the responses to comments. These comments and
the NIOSH responses are available at: <a href="https://www.regulations.gov/search/docket?filter=cdc-2016-0001">https://www.regulations.gov/search/docket?filter=cdc-2016-0001</a>.
The final CIB provides a comprehensive scientific review of the
scientific literature pertaining to occupational exposure to silver
nanomaterials. The literature includes studies of exposures to silver
nanomaterials in the workplace, toxicological effects of exposure to
silver nanomaterials in experimental animal and cellular systems, and
effects of particle size and other properties on the toxicological
effects of silver. NIOSH assessed the potential health risks of
occupational exposure to silver nanomaterials by evaluating the
scientific literature. Studies in animals have shown adverse lung and
liver effects associated with exposure to silver nanoparticles. Based
on an assessment of those data, NIOSH developed a REL for silver
nanomaterials. This new REL applies to processes that produce or use
silver nanomaterials in the workplace. In addition, NIOSH continues to
recommend its existing REL for total silver (metal dust and soluble
compounds, as Ag) [<a href="http://www.cdc.gov/niosh/npg/npgd0557.html">www.cdc.gov/niosh/npg/npgd0557.html</a>]. In the CIB,
NIOSH provides recommendations on the measurement and control of
occupational exposures to silver and silver nanomaterials.
NIOSH further recommends the use of workplace exposure assessments,
engineering controls, safe work procedures, training, and education,
and established medical surveillance approaches to prevent potential
adverse health effects from occupational exposure to silver
nanomaterials. NIOSH proposes research needed to fill remaining data
gaps on the potential adverse health effects of occupational exposure
to silver nanomaterials.
John J. Howard,
Director, National Institute for Occupational Safety and Health,
Centers for Disease Control and Prevention.
[FR Doc. 2021-11626 Filed 6-2-21; 8:45 am]
BILLING CODE 4163-18-P
</pre><script data-cfasync="false" src="/cdn-cgi/scripts/5c5dd728/cloudflare-static/email-decode.min.js"></script></body>
</html>Indexed from Federal Register on June 3, 2021.
This is legal information, not legal advice. Laws vary by jurisdiction and change frequently. Always verify current law with official sources and consult a licensed attorney in your jurisdiction for advice on your specific situation.